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Follow newly published governed evidence, regulatory records, and corrections. Draft, quarantined, and unresolved records do not appear here.

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  1. Regulatory record

    Thymosin beta-4 — United States — FDA

    FDA Drugs@FDA database

  2. Regulatory record

    Thymosin beta-4 — European Union — EMA

    European Medicines Agency medicines database

  3. Evidence added

    Nuclear factor (erythroid-derived 2)-like 2 counter-regulates thymosin beta-4 expression and primary cilium formation for HeLa cervical cancer cell survival.

    Thymosin beta-4 · 2022 · animal · DOI 10.1038/s41598-022-24596-6 · PMID 36424462

  4. Evidence added

    Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.

    Thymosin beta-4 · 2016 · animal · DOI 10.1371/journal.pone.0146708 · PMID 26789270

  5. Evidence added

    Protection of thymosin beta-4 on corneal endothelial cells from UVB-induced apoptosis.

    Thymosin beta-4 · 2010 · animal · DOI 10.4077/cjp.2010.amh091 · PMID 21793328

  6. Evidence added

    Actin-sequestering protein, thymosin beta-4, induces paclitaxel resistance through ROS/HIF-1α stabilization in HeLa human cervical tumor cells

    Thymosin beta-4 · 2010 · laboratory · DOI 10.1016/j.lfs.2010.07.002 · PMID 20637781

  7. Evidence added

    Thymosin beta-4 participate in antibacterial immunity and wound healing in black tiger shrimp, Penaeus monodon.

    Thymosin beta-4 · 2023 · animal · DOI 10.1016/j.fsi.2023.109065 · PMID 37689229

  8. Evidence added

    Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics.

    Thymosin beta-4 · 2017 · animal · DOI 10.1007/s11248-016-9988-7 · PMID 27900536

  9. Evidence added

    Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm delivery.

    Thymosin beta-4 · 2021 · animal · DOI 10.26355/eurrev_202101_24411 · PMID 33506933

  10. Evidence added

    No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart.

    Thymosin beta-4 · 2018 · animal · DOI 10.1002/prp2.407 · PMID 29864245

  11. Evidence added

    Localization of thymosin beta-4 in tumors.

    Thymosin beta-4 · 2007 · laboratory · DOI 10.1196/annals.1415.005 · PMID 17495241

  12. Evidence added

    Actin-sequestering protein, thymosin beta-4, is a novel hypoxia responsive regulator.

    Thymosin beta-4 · 2010 · animal · DOI 10.1007/s10585-010-9350-z · PMID 20821256

  13. Evidence added

    Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H<sub>2</sub>O<sub>2</sub> production-thymosin beta-4 gene expression.

    Thymosin beta-4 · 2021 · animal · DOI 10.7150/ijms.53595 · PMID 33526986

  14. Evidence added

    Tβ4-17 peptide enhances the chemo-sensitivity of ovarian cancer cells to DDP by affecting NF-κB signaling pathway.

    Thymosin beta-4 · 2025 · animal · DOI 10.1007/s12032-025-03106-4 · PMID 41205079

  15. Evidence added

    Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells.

    Thymosin beta-4 · 2022 · animal · DOI 10.1186/s13287-021-02687-x · PMID 35012642

  16. Evidence added

    In vivo growth suppression of CT-26 mouse colorectal cancer cells by adenovirus-expressed small hairpin RNA specifically targeting thymosin beta-4 mRNA.

    Thymosin beta-4 · 2014 · animal · DOI 10.1038/cgt.2014.43 · PMID 25124811

  17. Evidence added

    Cellular trafficking of thymosin beta-4 in HEPG2 cells following serum starvation.

    Thymosin beta-4 · 2013 · animal · DOI 10.1371/journal.pone.0067999 · PMID 23967050

  18. Evidence added

    Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals.

    Thymosin beta-4 · 2025 · animal · DOI 10.3390/ijms26094131 · PMID 40362372

  19. Evidence added

    Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.

    Thymosin beta-4 · 2017 · animal · DOI 10.1038/s41598-017-03782-x · PMID 28630423

  20. Evidence added

    A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis.

    Thymosin beta-4 · 2016 · animal · DOI 10.1016/j.dci.2015.12.007 · PMID 26695126

  21. Evidence added

    Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations.

    Thymosin beta-4 · 2018 · observational · DOI 10.1080/14712598.2018.1448382 · PMID 29502471

  22. Evidence added

    Expression of thymosin beta-4 and related genes in developing human brain

    Thymosin beta-4 · 1992 · laboratory · DOI 10.1007/bf02919408 · PMID 1627460

  23. Evidence added

    Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction.

    Thymosin beta-4 · 2017 · observational · DOI 10.1161/jaha.117.005586 · PMID 28611096

  24. Evidence added

    Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer.

    Thymosin beta-4 · 2022 · animal · DOI 10.1369/00221554221138370 · PMID 36321670

  25. Evidence added

    Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4.

    Thymosin beta-4 · 2015 · animal · DOI 10.18632/oncotarget.3218 · PMID 25888632

  26. Evidence added

    Hypoxia-inducible transcription factor (HIF)-1 alpha stabilization by actin-sequestering protein, thymosin beta-4 (TB4) in Hela cervical tumor cells.

    Thymosin beta-4 · 2008 · animal · DOI 10.1016/j.canlet.2008.01.004 · PMID 18272284

  27. Evidence added

    Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry.

    Thymosin beta-4 · 2017 · observational · DOI 10.1016/j.prp.2017.07.005 · PMID 28756979

  28. Evidence added

    Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.

    Thymosin beta-4 · 2025 · animal · DOI 10.1002/advs.202505009 · PMID 40279568

  29. Evidence added

    Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals.

    Thymosin beta-4 · 2023 · animal · DOI 10.1016/j.intimp.2023.109830 · PMID 38706788

  30. Evidence added

    Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.

    Thymosin beta-4 · 2023 · animal · DOI 10.1016/j.intimp.2023.109741 · PMID 36709593

  31. Evidence added

    The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis.

    Thymosin beta-4 · 2022 · animal · DOI 10.3390/ijms232113282 · PMID 36362069

  32. Evidence added

    Thymosin Beta-4 Induces Mouse Hair Growth.

    Thymosin beta-4 · 2015 · animal · DOI 10.1371/journal.pone.0130040 · PMID 26083021

  33. Regulatory record

    Pramlintide — United States — FDA

    FDA SYMLIN (pramlintide acetate) prescribing information

  34. Regulatory record

    Pramlintide — European Union — EMA

    European Medicines Agency medicines database

  35. Regulatory record

    Pemvidutide — European Union — EMA

    European Medicines Agency medicines database

  36. Regulatory record

    Pemvidutide — United States — FDA

    FDA Drugs@FDA database

  37. Regulatory record

    Mazdutide — United States — FDA

    FDA Drugs@FDA database

  38. Regulatory record

    Mazdutide — China — NMPA

    Innovent Announces Mazdutide, First Dual GCG/GLP-1 Receptor Agonist, Received Approval from China's NMPA for Chronic Weight Management

  39. Regulatory record

    Glucagon — United States — FDA

    FDA GlucaGen (glucagon) prescribing information

  40. Regulatory record

    Glucagon — European Union — EMA

    European Medicines Agency: Baqsimi (glucagon)