living literature

Research updates and alerts

Follow newly published governed evidence, regulatory records, and corrections. Draft, quarantined, and unresolved records do not appear here.

  1. Evidence added

    Successful treatment with teduglutide for an adolescent with cerebral palsy accompanied by short bowel syndrome.

    Teduglutide · insufficient · DOI 10.1111/ped.15894 · PMID 40019443

  2. Evidence added

    Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina.

    Teduglutide · insufficient · DOI 10.4292/wjgpt.v16.i4.110642 · PMID 41378076

  3. Evidence added

    Comment on "real-world experience of teduglutide for the treatment of short bowel syndrome-associated intestinal failure".

    Teduglutide · insufficient · DOI 10.1016/j.clnesp.2026.105083 · PMID 42674361

  4. Evidence added

    PERCC1-associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide.

    Teduglutide · insufficient · DOI 10.1002/jpr3.70144 · PMID 42110144

  5. Evidence added

    Teduglutide in Enterocolitis Secondary to Graft-Versus-Host Disease Post-Bone Transplant: Case Report

    Teduglutide · insufficient · DOI 10.20944/preprints202602.1566.v1

  6. Evidence added

    Effectiveness and Safety of Teduglutide Treatment in Adult Patients with Short Bowel Syndrome: A Case Series and Review of Current Evidence.

    Teduglutide · insufficient · DOI 10.3390/jcm15052033 · PMID 41827448

  7. Evidence added

    Safety and long-term effectiveness of teduglutide in children with intestinal failure due to short bowel syndrome: a multicenter, post-marketing cohort study.

    Teduglutide · insufficient · DOI 10.1038/s41390-026-05489-0 · PMID 42754721

  8. Evidence added

    Real-world effectiveness and safety of teduglutide in patients with short bowel syndrome.

    Teduglutide · insufficient · DOI 10.4292/wjgpt.v17.i1.117071 · PMID 41809219

  9. Evidence added

    Add-on to current guidelines for monitoring of SBS patients treated with teduglutide

    Teduglutide · insufficient · DOI 10.1038/s44355-025-00047-7

  10. Evidence added

    Dextran Sulfate/Pramlintide Polyelectrolyte Nanoparticles as a Promising Delivery System: Optimization, Evaluation of Supramolecular Interactions and Effect on Conformational Stability of the Peptide Drug

    Pramlintide · insufficient · DOI 10.21577/0103-5053.20210062

  11. Evidence added

    Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats

    Pramlintide · insufficient · DOI 10.1101/2021.04.12.439573

  12. Evidence added

    Slow post-induction specific growth rate enhances recombinant protein expression in Escherichia coli: Pramlintide multimer and ranibizumab production as case studies

    Pramlintide · insufficient · DOI 10.1016/j.procbio.2022.01.009

  13. Evidence added

    Effect of Zn(II) on pramlintide: structural kink, fibril formation, antifungal activity

    Pramlintide · insufficient · DOI 10.21203/rs.3.rs-1954176/v1

  14. Evidence added

    Development and validation of a new robust RP-HPLC method for simultaneous quantitation of insulin and pramlintide in non-invasive and smart glucose-responsive microparticles.

    Pramlintide · insufficient · DOI 10.4103/1735-5362.359428 · PMID 36704426

  15. Evidence added

    Dual-Hormone Insulin-and-Pramlintide Artificial Pancreas for Type 1 Diabetes: A Systematic Review

    Pramlintide · insufficient · DOI 10.3390/app122010262

  16. Evidence added

    Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide.

    Pramlintide · insufficient · DOI 10.3390/pharmaceutics14030553 · PMID 35335929

  17. Evidence added

    Linaclotide for Bowel Preparation: Is "Afterload Reduction" Not Just for Heart Failure Anymore?

    Linaclotide · insufficient · DOI 10.14309/ajg.0000000000003375 · PMID 40110861

  18. Evidence added

    Polysaccharide-peptide complexes stabilized around nanoemulsion droplets: A new approach for nasal delivering of pramlintide and insulin

    Pramlintide · insufficient · DOI 10.1016/j.jddst.2023.104527

  19. Evidence added

    QBD Approach for Design and Characterization of Pramlintide Microspheres for Controlled Drug Release

    Pramlintide · insufficient · DOI 10.1007/s12247-023-09795-6

  20. Evidence added

    Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids secrete fluid in response to forskolin and linaclotide

    Linaclotide · insufficient · DOI 10.1101/2025.02.03.636268

  21. Evidence added

    Beyond the injection: delivery systems reshaping retinal disease management.

    Elamipretide · insufficient · DOI 10.1080/14656566.2025.2496424 · PMID 40319468

  22. Evidence added

    Oral delivery of the amylin receptor agonist pramlintide

    Pramlintide · insufficient · DOI 10.1101/2023.11.09.566408

  23. Evidence added

    A pharmacovigilance study of the association between linaclotide/plecanatide and muscle spasms based on food and drug administration adverse event reporting system.

    Linaclotide · insufficient · DOI 10.3389/fphar.2025.1635792 · PMID 40843382

  24. Evidence added

    Intranasal administration of dextran-pramlintide polyelectrolyte complex-coated nanoemulsions improves cognitive impairments in a mouse model of Alzheimer's disease.

    Pramlintide · insufficient · DOI 10.1016/j.ijbiomac.2024.136158 · PMID 39362444

  25. Evidence added

    Constipation-predominant irritable bowel syndrome treatment options Linaclotide, Lubiprostone, Plecanatide, and Tenapanor: analysis of the FDA Adverse Event Reporting System (FAERS) database.

    Linaclotide · insufficient · DOI 10.1080/14740338.2025.2519833 · PMID 40503810

  26. Evidence added

    Correction to: Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK‑3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high‑fat dietstreptozocin rat model.

    Pramlintide · insufficient · DOI 10.1007/s00424-024-02959-4 · PMID 38575720

  27. Evidence added

    Clinical Study on the Application of Low-Dose 2L Lactulose Combined with Linaclotide in Bowel Preparation Before Colonoscopy

    Linaclotide · insufficient · DOI 10.21203/rs.3.rs-7391900/v1

  28. Evidence added

    Efficacy of linaclotide as adjunct for bowel preparation in patients with chronic constipation: a pre-specified analysis of the APPLE trial.

    Linaclotide · insufficient · DOI 10.5946/ce.2026.214 · PMID 42681900

  29. Evidence added

    Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.

    Linaclotide · insufficient · DOI 10.3389/fphar.2026.1761301 · PMID 42038325

  30. Evidence added

    Efficacy and safety of linaclotide plus polyethylene glycol for bowel preparation before colonoscopy in elderly Chinese patients: a systematic review and meta-analysis.

    Linaclotide · insufficient · DOI 10.3389/fmed.2026.1833539 · PMID 42482900

  31. Regulatory record

    Thymosin beta-4 — European Union — EMA

    European Medicines Agency medicines database

  32. Regulatory record

    Thymosin beta-4 — United States — FDA

    FDA Drugs@FDA database

  33. Regulatory record

    Pramlintide — European Union — EMA

    European Medicines Agency medicines database

  34. Regulatory record

    Pramlintide — United States — FDA

    FDA SYMLIN (pramlintide acetate) prescribing information

  35. Regulatory record

    Pemvidutide — United States — FDA

    FDA Drugs@FDA database

  36. Regulatory record

    Pemvidutide — European Union — EMA

    European Medicines Agency medicines database

  37. Regulatory record

    Mazdutide — China — NMPA

    Innovent Announces Mazdutide, First Dual GCG/GLP-1 Receptor Agonist, Received Approval from China's NMPA for Chronic Weight Management

  38. Regulatory record

    Mazdutide — United States — FDA

    FDA Drugs@FDA database

  39. Regulatory record

    Glucagon — United States — FDA

    FDA GlucaGen (glucagon) prescribing information

  40. Regulatory record

    Glucagon — European Union — EMA

    European Medicines Agency: Baqsimi (glucagon)