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Published peptide research references

Thymosin alpha-1

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25 approved source records with original-source links. Source verification confirms the reference and its connection to this record; it does not certify every scientific conclusion or establish safety or efficacy.

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Approved source records

  1. Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial.

    Xu H, Li F, Li B, Yang D, Liu T, Xia Y, Hua H, Li Q, Wang J, Liu H, Xu Z. · 2026

    DOI: 10.1186/s12916-026-04740-zPMID: 41749205

  2. Thymosin Alpha-1 Restores Chemotherapy-Induced Antitumor Immunity by Chaperoning a MicroRNA Ligand of TLR7 in Dendritic Cells.

    Wei Y, Chen J, Zhang Y, Liu Y, Zhu F, Wang X, Zhou X, Wu C, Zhang W, Chen J, Zhang Y, Pan N, Chen K, Zheng S, Yan C, Liu L, Wang L. · 2026

    DOI: 10.1158/0008-5472.CAN-25-5547PMID: 42295795

  3. Aging and Thymosin Alpha-1.

    Simonova MA, Ivanov I, Shoshina NS, Komyakova AM, Makarov DA, Baranovskii DS, Klabukov ID, Telepenina KP, Atiakshin DA, Shegay PV, Kaprin AD, Stepanenko VN. · 2025

    DOI: 10.3390/ijms262311470PMID: 41373628

  4. The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets.

    Solmonese L, Lofiego MF, Fazio C, Marzani F, Piazzini F, Bello E, Celesti F, Giacobini G, Wang X, Maio M, Coral S, Di Giacomo AM, Covre A. · 2025

    DOI: 10.2147/OTT.S527785PMID: 40955371

  5. Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy.

    Liu K, Kong L, Cui H, Zhang L, Xin Q, Zhuang Y, Guo C, Yao Y, Tao J, Gu X, Jiang C, Wu J. · 2024

    DOI: 10.1016/j.xcrm.2024.101751PMID: 39357524

  6. A Pilot Trial of Thymalfasin (Thymosin-α-1) to Treat Hospitalized Patients With Hypoxemia and Lymphocytopenia Due to Coronavirus Disease 2019 Infection.

    Shehadeh F, Benitez G, Mylona EK, Tran QL, Tsikala-Vafea M, Atalla E, Kaczynski M, Mylonakis E. · 2023

    DOI: 10.1093/infdis/jiac362PMID: 36056913

  7. Thymosin α-1 in cancer therapy: Immunoregulation and potential applications.

    Wei Y, Zhang Y, Li P, Yan C, Wang L. · 2023

    DOI: 10.1016/j.intimp.2023.109744PMID: 36812669

  8. Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis.

    Wei YT, Wang XR, Yan C, Huang F, Zhang Y, Liu X, Wen ZF, Sun XT, Zhang Y, Chen YQ, Gao R, Pan N, Wang LX. · 2022

    DOI: 10.1158/0008-5472.CAN-21-4260PMID: 35364609

  9. Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study.

    Liu J, Shen Y, Wen Z, Xu Q, Wu Z, Feng H, Li Z, Dong X, Huang S, Guo J, Zhang L, Chen Y, Li W, Zhu W, Du H, Liu Y, Wang T, Chen L, Teboul JL, Annane D, Chen D. · 2021

    DOI: 10.3389/fimmu.2021.673693PMID: 34408744

  10. Thymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells From Coronavirus Disease 2019 Patients.

    Matteucci C, Minutolo A, Balestrieri E, Petrone V, Fanelli M, Malagnino V, Ianetta M, Giovinazzo A, Barreca F, Di Cesare S, De Marco P, Miele MT, Toschi N, Mastino A, Sinibaldi Vallebona P, Bernardini S, Rogliani P, Sarmati L, Andreoni M, Grelli S, Garaci E. · 2020

    DOI: 10.1093/ofid/ofaa588PMID: 33506065

  11. Thymosin alpha 1: A comprehensive review of the literature.

    Dominari A, Hathaway Iii D, Pandav K, Matos W, Biswas S, Reddy G, Thevuthasan S, Khan MA, Mathew A, Makkar SS, Zaidi M, Fahem MMM, Beas R, Castaneda V, Paul T, Halpern J, Baralt D. · 2020

    DOI: 10.5501/wjv.v9.i5.67PMID: 33362999

  12. Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

    Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. · 2019

    DOI: 10.1038/s41598-019-46639-1PMID: 31311979

  13. Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.

    Tomati V, Caci E, Ferrera L, Pesce E, Sondo E, Cholon DM, Quinney NL, Boyles SE, Armirotti A, Ravazzolo R, Galietta LJ, Gentzsch M, Pedemonte N. · 2018

    DOI: 10.1172/jci.insight.98699PMID: 29415893

  14. Thymosin alpha-1 treatment in chronic hepatitis B.

    Wu X, Jia J, You H. · 2015

    DOI: 10.1517/14712598.2015.1007948PMID: 25640173

  15. Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma.

    Maio M, Mackiewicz A, Testori A, Trefzer U, Ferraresi V, Jassem J, Garbe C, Lesimple T, Guillot B, Gascon P, Gilde K, Camerini R, Cognetti F; Thymosin Melanoma Investigation Group. · 2010

    DOI: 10.1200/JCO.2009.25.5208PMID: 20194853

  16. Thymosin alpha 1: from bench to bedside.

    Garaci E, Favalli C, Pica F, Sinibaldi Vallebona P, Palamara AT, Matteucci C, Pierimarchi P, Serafino A, Mastino A, Bistoni F, Romani L, Rasi G. · 2007

    DOI: 10.1196/annals.1415.044PMID: 17600290

  17. Thymalfasin (thymosin-alpha 1) therapy in patients with chronic hepatitis B.

    Liaw YF. · 2004

    PMID: 15641208

  18. Thymosin alpha-1.

    Ancell CD, Phipps J, Young L. · 2001

    DOI: 10.1093/ajhp/58.10.886PMID: 11381492

  19. Thymosin alpha 1 does not promote growth or oncogenic transformation.

    Naylor PH, Smith MR, Mutchnick MG, Naylor CW, Dosescu J, Skunca M, Moshier JA. · 1996

    DOI: 10.1016/0192-0561(96)00032-xPMID: 8933211

  20. Immunotherapy with natural interleukins and/or thymosin alpha 1 potently augments T-lymphocyte responses of hydrocortisone-treated aged mice.

    Hadden JW, Saha A, Sosa M, Hadden EM. · 1995

    DOI: 10.1016/0192-0561(95)00069-ePMID: 8707447

  21. Nuclear targeting of prothymosin alpha.

    Manrow RE, Sburlati AR, Hanover JA, Berger SL. · 1991

    PMID: 1899869

  22. Localization of immunoreactive thymosin alpha 1 in astrocytes of normal human brain.

    Su YL, Ho KL, Dalakas MC, Mutchnick MG. · 1989

    DOI: 10.1002/ana.410260216PMID: 2774514

  23. Prothymosin alpha in human blood.

    Panneerselvam C, Haritos AA, Caldarella J, Horecker BL. · 1987

    DOI: 10.1073/pnas.84.13.4465PMID: 3474615

  24. Receptors for thymosin alpha 1 on mouse thymocytes.

    Rinaldi Garaci C, Torrisi MR, Jezzi T, Frati L, Goldstein AL, Garaci E. · 1985

    DOI: 10.1016/0008-8749(85)90051-6PMID: 3882244

  25. Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.

    Umeda Y, Sakamoto A, Nakamura J, Ishitsuka H, Yagi Y. · 1983

    DOI: 10.1007/BF00199694PMID: 6553515