Published peptide research references
Humanin
Governed registry record
326 approved source records with original-source links. Source verification confirms the reference and its connection to this record; it does not certify every scientific conclusion or establish safety or efficacy.
Open the peptide evidence profile →Approved source records
Characterization of the Effects of a Humanin Fragment Peptide (HNF<sub>14</sub>) in Age-Related Macular Degeneration.
DOI: 10.3390/jcm15051686PMID: 41827105
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Diagnostic Value of Serum Humanin-Like 3 Levels in Multiple Sclerosis Patients with Predominant Optic Nerve and Spinal Cord Involvement: A Preliminary Study.
DOI: 10.29399/npa.29115PMID: 41777515
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Diagnostic potential of serum humanin in breast cancer among the Egyptian population.
DOI: 10.1007/s12672-025-04325-xPMID: 41518474
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Humanin analogue promotes metabolic reprogramming to protect the ischemic heart
DOI: 10.64898/2026.06.16.732776
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Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
DOI: 10.3390/biomedicines14051048PMID: 42193373
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Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
DOI: 10.1177/07482337261445494PMID: 42041115
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Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.
DOI: 10.31083/ap54760PMID: 42694894
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Mitochondrial stress and mitokines in aging.
DOI: 10.1111/acel.13770PMID: 36642986
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Mitochondrial-Derived Peptides Exacerbate Senescence.
DOI: 10.1089/rej.2018.2114PMID: 30058454
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Mitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin.
DOI: 10.1093/ajrcmb/aanag116PMID: 42262906
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Mitochondrial-derived peptides in energy metabolism.
DOI: 10.1152/ajpendo.00249.2020PMID: 32776825
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Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.
DOI: 10.1186/s13195-023-01303-9PMID: 37730689
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Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
DOI: 10.21203/rs.3.rs-9572557/v1
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Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
DOI: 10.64898/2026.03.20.713049
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Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.
DOI: 10.1038/s41598-026-62834-3PMID: 42471450
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Renoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats
DOI: 10.21203/rs.3.rs-9040130/v1
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Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.
DOI: 10.3390/biology15131060PMID: 42450608
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Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.
2026
Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.
2026
Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.
2026
Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.
2026
Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.
2026
Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.
2026
Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.
2026
Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.
2026
Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.
2026
Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.
2026
Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.
2026
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.
2026
Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.
2026
Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
2026
Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).
2026
S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.
2026
S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.
2026
[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].
2026
A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.
2025
Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.
2025
Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.
2025
Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.
2025
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.
2025
Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.
2025
Humanin variants aggregate to produce different fibril morphologies.
2025
Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
2025
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
2025
Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.
2025
Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.
2025
S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.
2025
The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.
2025
Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.
2024
Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).
2024
Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.
2024
Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones.
2024
Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression.
2024
Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.
2024
Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.
2024
Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model.
2024
Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.
2024
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.
2024
Impaired Expression of Humanin during Adrenocortical Carcinoma.
2024
Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.
2024
SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.
2024
Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.
2024
[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.
2024
[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.
2024
A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.
2023
A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.
2023
A novel link between chronic inflammation and humanin regulation in children.
2023
Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat.
2023
Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.
2023
Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.
2023
Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.
2023
Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.
2023
Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.
2023
Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.
2023
Humanin gene expression in subjects with Parkinson's disease.
2023
Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease.
2023
PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.
2023
Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.
2023
S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.
2023
S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.
2023
S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.
2023
Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.
2023
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
2023
An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls.
2022
Cardio-protective role of Humanin in myocardial ischemia-reperfusion.
2022
Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.
2022
Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.
2022
Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa.
2022
Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls.
2022
Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).
2022
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.
2022
Humanin and Alzheimer's disease: The beginning of a new field.
2022
Humanin derivative, HNG, enhances neurotransmitter release.
2022
Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.
2022
Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).
2022
Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.
2022
Structural basis of FPR2 in recognition of Aβ<sub>42</sub> and neuroprotection by humanin.
2022
Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.
2022
The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.
2022
The protective effects of S14G-humanin on gestational diabetes mellitus symptoms.
2022
The role of humanin in natural stress tolerance: An underexplored therapeutic avenue.
2022
The role of humanin in the regulation of reproduction.
2022
[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.
2022
Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.
2021
Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.
2021
Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.
2021
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.
2021
Humanin: A Potential Treatment for PCOS?
2021
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.
2021
Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.
2021
Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.
2021
Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases.
2021
S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.
2021
The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.
2021
The emerging role of mitochondrial derived peptide humanin in the testis.
2021
The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.
2021
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.
2021
[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.
2021
Assay Development and Measurement of the Aging Biomarker Humanin.
2020
Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.
2020
HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.
2020
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men.
2020
Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.
2020
Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.
2020
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.
2020
Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.
2020
Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.
2020
Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.
2020
Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.
2020
Humanin: A mitochondria-derived peptide with emerging properties.
2020
Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP.
2020
Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.
2020
Murine maternal dietary restriction affects neural Humanin expression and cellular profile.
2020
Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.
2020
Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.
2020
The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.
2020
The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.
2020
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.
2020
[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.
2020
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.
2019
Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.
2019
Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.
2019
Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.
2019
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.
2019
Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.
2019
Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.
2019
Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.
2019
Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y).
2019
Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.
2019
Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage.
2019
Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.
2019
The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.
2019
The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.
2019
Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.
2019
A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.
2018
Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.
2018
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.
2018
Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.
2018
Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus.
2018
Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.
2018
Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway.
2018
Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury.
2018
Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.
2018
Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.
2018
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.
2018
Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.
2018
Humanin is an endogenous activator of chaperone-mediated autophagy.
2018
Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2.
2018
Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.
2018
Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.
2018
Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP.
2018
S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.
2018
Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.
2018
The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.
2018
[The level of circulating humanin in patients with ischemic heart disease.]
2018
Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
2017
Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.
2017
Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.
2017
High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.
2017
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.
2017
Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.
2017
Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.
2017
Humanin ameliorates diazepam-induced memory deficit in mice.
2017
Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.
2017
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.
2017
Neuroprotective effect of G<sup>14</sup>-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.
2017
Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.
2017
Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates.
2017
Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.
2016
Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction.
2016
Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.
2016
Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.
2016
Humanin: Functional Interfaces with IGF-I.
2016
Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.
2016
Potential Roles of Humanin on Apoptosis in the Heart.
2016
Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.
2016
Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.
2016
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
2016
The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.
2016
[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.
2016
Central effects of humanin on hepatic triglyceride secretion.
2015
Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.
2015
Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.
2015
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
2015
Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.
2015
Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.
2015
Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.
2015
Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.
2015
The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.
2015
The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.
2015
The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.
2015
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
2014
Apollon/Bruce is upregulated by Humanin.
2014
Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.
2014
Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.
2014
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.
2014
Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.
2014
IGF-I regulates the age-dependent signaling peptide humanin.
2014
Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog.
2014
New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.
2014
Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells.
2014
Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.
2014
Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.
2014
A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.
2013
Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.
2013
Circulating humanin levels are associated with preserved coronary endothelial function.
2013
Humanin binds MPP8: mapping interaction sites of the peptide and protein.
2013
Humanin: a harbinger of mitochondrial-derived peptides?
2013
Humanin: a novel functional molecule for the green synthesis of graphene.
2013
Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.
2013
Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.
2013
Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.
2013
S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.
2013
SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.
2013
Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.
2013
The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis.
2013
The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
2013
[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.
2013
[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.
2013
D-Ser-containing humanin shows promotion of fibril formation.
2012
Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.
2012
Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.
2012
Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.
2012
Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.
2012
S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.
2012
[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].
2012
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
2011
Advances in characterization of neuroprotective peptide, humanin.
2011
Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.
2011
Humanin signal for Alzheimer's disease.
2011
Structure of three Humanin peptides with different activities upon interaction with liposome.
2011
The biological activity of Humanin analogs correlates with structure stabilities in solution.
2011
VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
2011
[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].
2011
Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.
2010
Humanin and the receptors for humanin.
2010
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.
2010
Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.
2010
Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties
2010
Immunolocalization of humanin in human sperm and testis.
2010
Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.
2010
Structure changes of natively disordered Humanin in the presence of lipid.
2010
Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.
2010
The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.
2010
[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].
2010
[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.
2010
Evidence for potential functionality of nuclearly-encoded humanin isoforms.
2009
Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.
2009
Humanin structural versatility and interaction with model cerebral cortex membranes.
2009
Humanin: a novel central regulator of peripheral insulin action.
2009
Humanin; a defender against Alzheimer's disease?
2009
Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.
2009
In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.
2009
Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis
2009
Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.
2008
Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway
2008
Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.
2008
The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.
2008
The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues
2008
Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.
2007
Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.
2007
Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.
2006
Humanin Is a Novel Neuroprotective Agent Against Stroke
2006
Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.
2006
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia
2006
Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.
2006
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.
2006
The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.
2006
Zinc(II) binds to the neuroprotective peptide humanin.
2006
[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].
2006
[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].
2006
A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice
2005
Construction of a eukaryotic expression plasmid of Humanin.
2005
Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
2005
Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo
2005
Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA
2005
Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches
2005
Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak
2005
Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase
2005
Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent
2005
Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.
2005
Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.
2005
Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.
2005
Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.
2004
High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.
2004
Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.
2004
Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.
2004
Humanin: After the Discovery
2004
Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.
2004
N-Formylated humanin activates both formyl peptide receptor-like 1 and 2
2004
Unravelling the role of Humanin.
2004
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults
2003
Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes
2003
Humanin peptide suppresses apoptosis by interfering with Bax activation
2003
Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40
2003
Humanin rescues cortical neurons from prion-peptide-induced apoptosis
2003
Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity
2003
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults
2003
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
2003
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization
2003
A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.
2002
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults
2002
Humanin inhibits cell death of serum-deprived PC12h cells
2002
Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults
2001
Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein
2001
[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.
2001