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Experience 2.0

Mitochondrial-derived peptide

Humanin

Humanin is a mitochondrial-derived peptide investigated in cellular stress and metabolic biology. Associations involving circulating humanin and experiments with related fragments do not establish a treatment in humans.

Record status

Traceability partial

Last meaningful update: 9/26/2026

Evidence searched through:
Not recorded
Assessment updated:
9/26/2026
Documented human review:
No documented human review recorded
Automated scientific assessment:
None recorded
AI source check:
9/26/2026

Published source links and profile text pass separate gates. Only a documented human review is labelled as human review; an automated scientific assessment applies deterministic checks, and an AI source check confirms only that a source exists and matches its identifiers. A source count alone does not establish a review.

Evidence coverage has three distinct layers. The corpus count is a transparent screening inventory, the featured set contains study-level tiering and interpretation, and the published-source count contains records promoted through the institutional publication workflow. Source validation, editorial publication, and scientific appraisal are separate decisions; these numbers must not be merged.

Ranked research corpus

500

Categorized publications with provisional ranking; scientific review remains separate.

Featured tiered studies

0

Cornerstone publications with study-level interpretation, limitations, and tier disclosure.

Research domains

6

Clinical and scientific questions synthesized independently across the evidence atlas.

Published source records

326

Database records promoted through the governed publication workflow—not the corpus total.

Corpus generated 2026-09-18. Counts remain separately labeled so screening is not represented as completed review.

Human experience · separate evidence stream

No community pattern is displayed yet

Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.

Observation is valuable human context. It is not evidence of causation, efficacy, or safety.

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n ≥ 20 eligible observations

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Intelligence snapshot

The state of the record

A compact view of what is represented, what remains unresolved, and how completely the record can be traced.

Ranked research corpus

500

Categorized screening records; proposed rankings remain pending human appraisal.

Featured tiered studies

0

Cornerstone studies with published study-level interpretation and tier disclosure.

Research domains

6

Independent evidence dossiers covering the major research questions.

Published source records

326

Source records published through the governed workflow; this count does not certify scientific conclusions.

Contradictions

0

Conflicting evidence relationships that remain visible.

Research gaps

1

Questions the current record identifies as unresolved.

Connected media

0

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What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

6 published domain syntheses connected to 0 featured studies

Humanin no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded synthesis, confidence level, evidence context, limitations, geographic applicability, regulatory interpretation, and research gaps. Publication of these syntheses is separate from the scientific review status shown above.

Inspect the reconciled evidence atlas
Inspect the published evidence record326 governed records · titles, provenance, and original-source linksOpen records ↓
2026Observational human evidence

Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.

Content-verified record concerning Humanin: "Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle." Abstract excerpt: The present study aimed to assess the presence of humanin in the sperm of crossbred cattle bulls using immunocytochemistry and to evaluate its potential as a semen quality marker. For this, a total of 49 ejaculates were collected from three Vrindavani crossbred bulls and were evaluated for volume, individual progressive motility (IPM), abnormality, and sperm concentration. The ejaculates were grou

Source
peer_reviewed_research
DOI
10.1111/rda.70240
PubMed
42223320
Open original source
2024Observational human evidence

Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.

Content-verified record concerning Humanin: "Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer." Abstract excerpt: Lung and breast cancer are the most frequent causes of death from cancer globally. The objectives of this research were to evaluate the serum mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and humanin levels in lung or breast cancer patients, and investigate the impacts of radiation therapy on the circulating levels of these peptides. 35 lung cancer patients, 34 breast cancer patients

Source
peer_reviewed_research
DOI
10.2174/0118744710254730231114181358
PubMed
38314601
Open original source
2020Observational human evidence

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.

Content-verified record concerning Humanin: "The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan." Abstract excerpt: Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in C. elegans the overexpression of humanin is sufficient to increase lifespan, dependent on daf-16/Foxo . Humanin transgenic mice have many phenotypes that overlap with the worm

Source
peer_reviewed_research
DOI
10.18632/aging.103534
PubMed
32575074
Open original source
2025Observational human evidence

Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.

Content-verified record concerning Humanin: "Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification." Abstract excerpt: This study aimed to evaluate the diagnostic significance of circulating mitochondrial-derived peptides, Humanin and MOTS-c, the long non-coding RNA GAS5, and exosomal microRNAs miR-21 and miR-103 in stratifying prostate diseases, including benign prostatic hyperplasia (BPH), precancerous lesions (PL), and prostate cancer (PCa). These biomarkers were selected based on their established roles in cel

Source
peer_reviewed_research
DOI
10.1007/s10238-025-01810-z
PubMed
40768089
Open original source
2024Observational human evidence

Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.

Content-verified record concerning Humanin: "Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study." Abstract excerpt: Mortality and cardiovascular (CV) risk prediction in individuals with end-stage kidney disease (ESKD) on chronic hemodialysis (HD) remains challenging due to the multitude of implicated factors. In a multicenter ESKD-HD cohort, we tested the prognostic yield of the assessment of circulating Humanin, a small mitochondrial-derived peptide involved in CV protection, on CV events and mortality. W

Source
peer_reviewed_research
DOI
10.1007/s40620-024-02032-4
PubMed
39102184
Open original source
2026Observational human evidence

Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.

Content-verified record concerning Humanin: "Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients." Abstract excerpt: Cardiovascular morbidity and mortality (CVMM) remain highly prevalent among end-stage kidney disease (ESKD) patients undergoing chronic hemodialysis (HD). Nevertheless, risk prediction in this setting is limited by the complexity of factors involved and the individual patients' characteristics. In this study, we evaluated whether circulating levels of Humanin, a micropeptide reflecting mitochondri

Source
peer_reviewed_research
DOI
10.1159/000551517
PubMed
41849628
Open original source
2024Observational human evidence

SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.

Content-verified record concerning Humanin: "SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME." Abstract excerpt: Background: Multiple-organ dysfunction syndrome disproportionately contributes to pediatric sepsis morbidity. Humanin (HN) is a small peptide encoded by mitochondrial DNA and thought to exert cytoprotective effects in endothelial cells and platelets. We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of

Source
peer_reviewed_research
DOI
10.1097/shk.0000000000002266
PubMed
37917869
Open original source
2022Observational human evidence

Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.

Content-verified record concerning Humanin: "Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension." Abstract excerpt: Autophagy, a highly conserved homeostatic mechanism, is essential for cell survival. The decline of autophagy function has been implicated in various diseases as well as aging. Although mitochondria play a key role in the autophagy process, whether mitochondrial-derived peptides are involved in this process has not been explored. We developed a high through put screening method to identify potenti

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130017
PubMed
34624450
Open original source
2025Observational human evidence

HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.

Content-verified record concerning Humanin: "HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation." Abstract excerpt: Elimination of apoptotic neutrophils by macrophages, a process called efferocytosis, is a critical step in the resolution of inflammation. Efferocytosis induces the reprogramming of macrophages towards a pro-resolving phenotype and triggers the secretion of pro-resolving factors. While mouse efferocytic macrophages are well-described, less is known about human efferocytic macrophages. Here, using

Source
peer_reviewed_research
DOI
10.1038/s41419-025-07909-1
PubMed
40877234
Open original source
2018Observational human evidence

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

Content-verified record concerning Humanin: "Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans." Abstract excerpt: Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease. Here we demonstrate that humanin administration has neuropr

Source
peer_reviewed_research
DOI
10.1038/s41598-018-32616-7
PubMed
30242290
Open original source
2016Animal research

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

Content-verified record concerning Humanin: "The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction." Abstract excerpt: To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death, mitochondrial bioenergetics, and senescence. Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal microscopy. Human RPE cells were treated with 150 μM tert-Butyl hydroperoxide (tBH) in the absence/presence of

Source
peer_reviewed_research
DOI
10.1167/iovs.15-17053
PubMed
26990160
Open original source
2006Animal research

Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.

Content-verified record concerning Humanin: "Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis." Abstract excerpt: Humanin (HN) is a 24 amino acids peptide with potent neuro-survival properties that protects against damage associated with Alzheimer's disease. In the present report, we have demonstrated by immunohistochemical analysis and Western blotting the pattern of expression of rat humanin (HNr) in the testis of 10- to 60-day-old rats. The Leydig cells of 10- and 40- day-old rats expressed this peptide at

Source
peer_reviewed_research
DOI
10.1002/jcp.20672
PubMed
16619233
Open original source
2005Animal research

Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.

Content-verified record concerning Humanin: "Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity." Abstract excerpt: Humanin is a newly identified 24-residue peptide that suppresses neuronal cell death caused by a wide spectrum of familial Alzheimer's disease genes and the beta-amyloid peptide. In this study, NMR and circular dichroism studies of synthetic humanin in aqueous and 30% 2,2,2-trifluoroethanol (TFE) solutions are reported. In aqueous solution, humanin exists predominantly in an unstructured conformat

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2005.01.100
PubMed
15721287
Open original source
2020Animal research

Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.

Content-verified record concerning Humanin: "Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury." Abstract excerpt: Oxidative stress-induced injury and apoptosis of human lens epithelial cells (HLECs) are early events in the development of age‑related cataracts (ARCs). Humanin (HN) is a mitochondrial‑related peptide that serves a cytoprotective role in various cell types and animal models. Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane

Source
peer_reviewed_research
DOI
10.3892/mmr.2020.11202
PubMed
32627019
Open original source
2024Animal research

Impaired Expression of Humanin during Adrenocortical Carcinoma.

Content-verified record concerning Humanin: "Impaired Expression of Humanin during Adrenocortical Carcinoma." Abstract excerpt: The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, humanin has been identified as a crucial factor for maintaining cell survival and preventing cell death under various conditions. Adrenocortical

Source
peer_reviewed_research
DOI
10.3390/ijms25021038
PubMed
38256114
Open original source
2023Animal research

Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat.

Content-verified record concerning Humanin: "Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat." Abstract excerpt: This study examined humanin expression in rat ovarian tissue, its cellular localization, and its correlation with rat age under physiological conditions. A total of 40 Sprague-Dawley rats of various ages (2, 12, 30, and 60 days old and 1 year old) were grouped by age. Immunofluorescence and immunohistochemical techniques were used to observe humanin expression and cellular location in the ovarian

Source
peer_reviewed_research
DOI
10.1007/s11596-023-2732-7
PubMed
37115400
Open original source
2021Animal research

Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases.

Content-verified record concerning Humanin: "Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases." Abstract excerpt: Physiological reactive oxygen species (ROS) are important regulators of intercellular signal transduction. Oxidative and antioxidation systems maintain a dynamic balance under physiological conditions. Increases in ROS levels destroy the dynamic balance, leading to oxidative stress damage. Oxidative stress is involved in the pathogenesis of aging-related cardiovascular diseases (ACVD), such as ath

Source
peer_reviewed_research
DOI
10.3389/fendo.2021.683151
PubMed
34177809
Open original source
2013Animal research

Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.

Content-verified record concerning Humanin: "Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide." Abstract excerpt: Humanin (HN) has been proved to be an extensive neuroprotective peptide against AD-related and unrelated insults, but little is know about the effect of HN in inflammation response. Current studies indicated the receptors of HN have a close relationship with immune system, which led us to hypothesize HN might have a role in inflammatory response. In this study, we used lipopolysaccharide (LPS) to

Source
peer_reviewed_research
DOI
10.1007/s11064-012-0951-6
PubMed
23277413
Open original source
2010Animal research

The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.

Content-verified record concerning Humanin: "The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice." Abstract excerpt: Pancreatic beta-cell apoptosis is important in the pathogenesis and potential treatment of type 1 diabetes mellitus. We investigated whether Humanin, a recently described survival factor for neurons, could improve the survival of beta-cells and delay or treat diabetes in the nonobese diabetic (NOD) model. Humanin reduced apoptosis induced by serum starvation in NIT-1 cells and decreased apoptosis

Source
peer_reviewed_research
DOI
10.1016/j.metabol.2009.08.001
PubMed
19800083
Open original source
2022Animal research

Cardio-protective role of Humanin in myocardial ischemia-reperfusion.

Content-verified record concerning Humanin: "Cardio-protective role of Humanin in myocardial ischemia-reperfusion." Abstract excerpt: Mitochondria-derived peptides (MDPs) are bioactive peptides encoded by and secreted from the mitochondria. To date, a few MDPs including humanin, MOTS-c and SHLP1-6, and their diverse biological functions have been identified. The first and most studied MDP is humanin, a 24-amino-acid poly peptide. It was first identified in 2001 in the surviving neurons of patient with Alzheimer's disease, and si

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130066
PubMed
34896254
Open original source
2019Animal research

The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.

Content-verified record concerning Humanin: "The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes." Abstract excerpt: Mitochondrially derived peptides (MDPs) such as humanin (HN) have shown a remarkable ability to modulate neurological amyloids and apoptosis-associated proteins in cells and animal models. Recently, we found that humanin-like peptides also inhibit amyloid formation outside of neural environments in islet amyloid polypeptide (IAPP) fibrils and plaques, which are hallmarks of Type II diabetes. Howev

Source
peer_reviewed_research
DOI
10.1021/jacs.9b04995
PubMed
31456396
Open original source
2018Animal research

[The level of circulating humanin in patients with ischemic heart disease.]

Content-verified record concerning Humanin: "[The level of circulating humanin in patients with ischemic heart disease.]" Abstract excerpt: At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to the presence of secondary mitochondrial dysfunction in patients with coronary heart disease. Сoronary heart disease is generally accompanied with a decline in mitochondrial respiration and represents the root cause of metabolic abnormali

Source
peer_reviewed_research
DOI
10.18821/0869-2084-2018-63-8-466-470
PubMed
30726649
Open original source
2023Animal research

A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.

Content-verified record concerning Humanin: "A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury." Abstract excerpt: A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R) injury. Humanin (HN), a recently identified mitochondrial polypeptide, exhibits antioxidative and antiapoptotic properties. This work aimed to study the role of HN in a model of experimental intestinal I/R injury and its effect on associated dysmotilit

Source
peer_reviewed_research
DOI
10.1007/s00424-023-02804-0
PubMed
37020079
Open original source
2023Animal research

Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.

Content-verified record concerning Humanin: "Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats." Abstract excerpt: Diabetes mellitus (DM) is associated with numerous complications, including nephropathy, which principally occur due to hyperglycemia-induced oxidative stress and inflammation. Humanin (HN), a novel peptide generated from mitochondria, has anti-oxidant and anti-inflammatory potential as observed in different disease models. However, role of HN in diabetic nephropathy (DN) has not yet bee

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2023.171014
PubMed
37119975
Open original source
2023Animal research

Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.

Content-verified record concerning Humanin: "Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance." Abstract excerpt: Breast cancer is a leading cause of cancer death in women worldwide, and early detection is crucial for effective treatment. Mitochondrial dysfunction has been linked to cancer development and progression. Humanin, a mitochondrial-derived peptide, has been shown to have cytoprotective effects and may be involved in breast cancer development. In this study, we aimed to investigate the potential of

Source
peer_reviewed_research
DOI
10.1080/1354750x.2023.2246700
PubMed
37552125
Open original source
2017Animal research

Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates.

Content-verified record concerning Humanin: "Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates." Abstract excerpt: In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human H

Source
peer_reviewed_research
DOI
10.24272/j.issn.2095-8137.2017.049
PubMed
28825450
Open original source
2013Animal research

The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis.

Content-verified record concerning Humanin: "The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis." Abstract excerpt: We have previously demonstrated that the mitochondria-derived cytoprotective peptide humanin (HN), when administered intratesticularly to rats, rescues germ cells from apoptosis secondary to testicular stress of hormonal deprivation induced by gonadotropin-releasing hormone antagonist (GnRH-A). To decipher the cellular mechanisms of HN action in the amelioration of GnRH-A-induced germ cell apoptos

Source
peer_reviewed_research
DOI
10.1111/j.2047-2927.2013.00091.x
PubMed
23686888
Open original source
2011Animal research

The biological activity of Humanin analogs correlates with structure stabilities in solution.

Content-verified record concerning Humanin: "The biological activity of Humanin analogs correlates with structure stabilities in solution." Abstract excerpt: A single mutation has resulted in large differences in neuroprotective activity of a 24 amino acid Humanin (HN). A mutation of Ser7Ala (S7A-HN) resulted in loss of activity, while a mutation of Ser14Gly (S14G-HN) resulted in about 1000-fold increase. The mechanism of the effects conferred by these mutations have been totally unclear, although our recent structure analysis suggested a possibility o

Source
peer_reviewed_research
DOI
10.1016/j.ijbiomac.2011.04.003
PubMed
21510972
Open original source
2025Animal research

The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.

Content-verified record concerning Humanin: "The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects." Abstract excerpt: Humanin (HN) is an endogenous micropeptide also known as a mitochondria-derived peptide. It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine and attenuating the development of oxidative stress and associated neurotoxicity. HN protects the neuron from the toxic effects of amyloid beta (A&#x3b2;). HN is regarded

Source
peer_reviewed_research
DOI
10.1016/j.ejphar.2025.177510
PubMed
40090538
Open original source
2019Animal research

Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.

Content-verified record concerning Humanin: "Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury." Abstract excerpt: Skin provides the protective barrier for our body and undergoes the continuous regeneration in order to overcome damage from exposure to harmful environments and wounds. Epidermal stem cells (ESCs) play critical roles in skin regeneration. Humanin analogue, S14G-humanin (HNG), a prominent member of a newly discovered family of mitochondrial-derived peptides, has been shown to be a cytoprotective d

Source
peer_reviewed_research
DOI
10.1016/j.biopha.2018.11.059
PubMed
30508736
Open original source
2002Animal research

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.

Content-verified record concerning Humanin: "A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity." Abstract excerpt: We report the identification of a novel rat cDNA encoding a peptide homologous to Humanin, a secreted peptide that specifically protects against neuronal cell death induced by beta-amyloid peptide (Ab) or by mutations causing early-onset familial Alzheimer's disease. The rat gene, which we termed Rattin, encodes a peptide of 38 residues (15 residues longer than Humanin) showing 73% identity in the

Source
peer_reviewed_research
DOI
10.1096/fj.02-0018fje
PubMed
12154011
Open original source
2014Animal research

Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells.

Content-verified record concerning Humanin: "Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells." Abstract excerpt: Humanin (HN) is known for its anti-apoptotic functions in neuronal cells. In this study, we sought to investigate the protective effect of [Gly14]-Humanin (HNG) in high glucose (HG)-induced apoptosis of human umbilical vein endothelial cells (HUVECs). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to examine cell viability, DNA chromatin morphology was assessed u

Source
peer_reviewed_research
DOI
10.1016/j.diabres.2014.09.020
PubMed
25451915
Open original source
2026Animal research

Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.

Content-verified record concerning Humanin: "Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull." Abstract excerpt: The sperm quality, freezability, and fertility of crossbred bulls exhibit significant unpredictability, which consequently impacts the breeding program. The present study documents the supplementation of humanin, a mitochondria-derived peptide, on crossbred bull's sperm quality, freezability, antioxidant status and in-vitro fertility. For this objective a total of 24 ejaculates, 8 from each of the

Source
peer_reviewed_research
DOI
10.1038/s41598-025-30931-4
PubMed
41634054
Open original source
2026Animal research

Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.

Content-verified record concerning Humanin: "Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions." Abstract excerpt: In brief: Redox imbalance compromises granulosa cell survival and follicle fate. This study identifies the mitochondrial-derived peptide Humanin (HN) as a cytoprotective factor that protects granulosa cells under oxidative condItions. Abstract: Granulosa cell function is essential for proper ovarian physiology. Redox imbalance compromises granulosa cell survival, thereby impacting follicle fate wi

Source
peer_reviewed_research
DOI
10.1093/reprod/xaag082
PubMed
42397223
Open original source
2023Animal research

Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.

Content-verified record concerning Humanin: "Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis." Abstract excerpt: Diabetes is known to cause cognitive impairments through various mechanisms, including oxidative stress, inflammation, and apoptosis. Humanin (HN) has been shown to have protective effects on cognitive impairments induced by factors such as A&#x3b2;, muscarinic receptor antagonists, and aging in rodents. However, the mechanisms underlying the protective effects of HN in the prefrontal cortex and h

Source
peer_reviewed_research
DOI
10.1016/j.bbr.2023.114584
PubMed
37467966
Open original source
2019Animal research

Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.

Content-verified record concerning Humanin: "Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases." Abstract excerpt: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role in the cellular stress response. The first reported and better characterized MDP is humanin (HN), which exerts robust protective effects against a myriad of cytotoxic stimuli in many cell typ

Source
peer_reviewed_research
DOI
10.1080/14728222.2019.1559300
PubMed
30582721
Open original source
2010Animal research

Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.

Content-verified record concerning Humanin: "Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction." Abstract excerpt: Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD), and is considered as an early event in AD pathology. Humanin (HN) and its derivative, [Gly14]-Humanin (HNG), are known for their ability to suppress neuronal death induced by AD-related insults in vitro and in vivo. In the present study, we investigated the neuroprotective effects

Source
peer_reviewed_research
DOI
10.1016/j.neuint.2009.11.015
PubMed
19941922
Open original source
2022Animal research

The protective effects of S14G-humanin on gestational diabetes mellitus symptoms.

Content-verified record concerning Humanin: "The protective effects of S14G-humanin on gestational diabetes mellitus symptoms." Abstract excerpt: Gestational diabetes mellitus is a frequently diagnosed glucose metabolic disorder during pregnancy. Diabetes mellitus has been found to pose important health risks to the developing fetus, mother, and offspring. Here, we investigated the protective effects of S14G-humanin, a potent humanin analogue, against maternal and neonatal adverse outcomes in mice with diabetes mellitus. The results show th

Source
peer_reviewed_research
DOI
10.1080/09513590.2022.2073348
PubMed
35536048
Open original source
2022Animal research

The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.

Content-verified record concerning Humanin: "The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis." Abstract excerpt: Gout is a common and complex form of arthritis that has brought great inconveniences to the normal lives of patients. It is reported that oxidative stress and nod-like receptor family protein 3 (NLRP3) inflammasome-mediated inflammatory reactions are involved in the pathogenesis of gout arthritis. S14G-humanin (S14G-HNG) is a modified peptide of HNG with higher inhibitory activity on the accumulat

Source
peer_reviewed_research
DOI
10.1080/21655979.2021.2001911
PubMed
34965184
Open original source
2021Animal research

The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.

Content-verified record concerning Humanin: "The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction." Abstract excerpt: Excessive oxidative stress, inflammation, and myocardial hypertrophy have been associated with diabetic cardiomyopathy (DCM). S14G-humanin (HNG) is a potent humanin analogue that has demonstrated cytoprotective effects in a variety of cells and tissues. However, the pharmacological function of HNG in diabetic cardiomyopathy has not yet been reported. In the present study, we investigated the prote

Source
peer_reviewed_research
DOI
10.1080/21655979.2021.1964894
PubMed
34506248
Open original source
2006Animal research

Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.

Content-verified record concerning Humanin: "Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease." Abstract excerpt: The NMR solution study of Ser14Gly-humanin (S14G-HN), a 1000-fold more potent derivative of humanin (HN), is reported. HN is 24-residue peptide that selectively suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults and offers hope for the development of a cure against AD. In aqueous solution the NMR data show that S14G-HN is a flexible peptide with turn-like structures

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2006.08.087
PubMed
16945331
Open original source
2025Animal research

Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.

Content-verified record concerning Humanin: "Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms." Abstract excerpt: Can Gly[14]-humanin (HNG) improve cyclophosphamide-induced premature ovarian insufficiency (POI)? A POI model was induced in female rats by intraperitoneal injection of cyclophosphamide, followed by treatment with an intraperitoneal injection of HNG. Ovarian weight, ovarian index, regularity of the oestrous cycle, numbers of various types of follicle, hormone concentrations, and expression of the

Source
peer_reviewed_research
DOI
10.1016/j.rbmo.2025.104901
PubMed
40639309
Open original source
2018Animal research

A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.

Content-verified record concerning Humanin: "A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity." Abstract excerpt: Humanin (HN), a 24-amino acid bioactive peptide, has been shown to increase cell survival of neurons after exposure to A&#x3b2; and NMDA-induced toxicity and thus could be beneficial in the treatment of Alzheimer's disease (AD). The neuroprotection by HN is reported to be primarily through its agonist binding properties to the gp130 receptor. However, the peptidic nature of HN presents challenges

Source
peer_reviewed_research
DOI
10.1021/acschemneuro.7b00350
PubMed
29161500
Open original source
2020Animal research

The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.

Content-verified record concerning Humanin: "The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change." Abstract excerpt: Astrocytes are an integral component of the neurovascular unit where they act as homeostatic regulators, especially after brain injuries, such as stroke. One process by which astrocytes modulate homeostasis is the release of functional mitochondria (Mt) that are taken up by other cells to improve their function. However, the mechanisms underlying the beneficial effect of Mt transfer are unclear an

Source
peer_reviewed_research
DOI
10.1523/jneurosci.2212-19.2020
PubMed
31980585
Open original source
2025Animal research

A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.

Content-verified record concerning Humanin: "A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders." Abstract excerpt: Autophagy is a self-eating cellular process in which the cell breaks down worn-out organelles, damaged/defective proteins, and toxins. Impaired autophagy is a significant factor in the development of various metabolic disorders, along with oxidative stress, inflammation, mitochondrial and endoplasmic reticulum dysfunction. These disorders pose a significant health and economic burden on the global

Source
peer_reviewed_research
DOI
10.2174/0109298665363711250112050930
PubMed
39950467
Open original source
2023Animal research

Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.

Content-verified record concerning Humanin: "Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns." Abstract excerpt: Humanin is the first identified mitochondrial-derived peptide. Humanin-G (HNG) is a variant of Humanin that has significantly higher cytoprotective properties. Here, we describe the stability features of HNG in different conditions and characterize HNG degradation, oxidation, and dimerization patterns over short-term and long-term periods. HNG solutions were prepared in high-performance liquid chr

Source
peer_reviewed_research
DOI
10.3390/biom13030515
PubMed
36979450
Open original source
2016Animal research

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.

Content-verified record concerning Humanin: "The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus." Abstract excerpt: Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin and its analogues have a protective role in multiple age-related diseases including type 2 diabetes and Alzheimer's disease, through cytoprotective and neuroprotective effects both in vitro and in vivo. However, the humanin-mediated signaling pathways are not well understood. In this paper, we demonstrate that

Source
peer_reviewed_research
DOI
10.18632/oncotarget.10380
PubMed
27384491
Open original source
2010Animal research

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.

Content-verified record concerning Humanin: "Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury." Abstract excerpt: Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection. In this study, we examined the protective effects of an apoptosis inhibitor Gly(14)-humanin (HNG) and a necroptosis inhibitor necrostatin-1 (Nec-1) on hypoxia/ischemia/reperfusion injury. Cultured mouse primary cortical ne

Source
peer_reviewed_research
DOI
10.1016/j.brainres.2010.07.080
PubMed
20682300
Open original source
2005Animal research

Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo

Content-verified record concerning Humanin: "Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo" Abstract excerpt: Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a short bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-causative genes and amyloid-beta (Abeta) in vitro. It has been shown that HN suppresses memory impairment of mice induced by intracerebroventricular administration of Abeta. To potentiate the neuroprotective effect of HN, we sy

Source
peer_reviewed_research
DOI
10.1523/jneurosci.3348-05.2005
PubMed
16267233
Open original source
2002Animal research

Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

Content-verified record concerning Humanin: "Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults" Abstract excerpt: An unbiased functional screening with brain cDNA library from an Alzheimer's disease (AD) brain identified a novel 24-residue peptide Humanin (HN), which suppresses AD-related neurotoxicity. As the 1567-base cDNA containing the open reading frame (ORF) of HN is 99% identical to mitochondrial 16S ribosomal RNA as well as registered human mRNA, it was elusive whether HN is produced in vivo. Here, we

Source
peer_reviewed_research
DOI
10.1016/s0304-3940(02)00199-4
PubMed
12009529
Open original source
2018Animal research

Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.

Content-verified record concerning Humanin: "Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors." Abstract excerpt: Pituitary tumors are the most common primary intracranial neoplasms. Humanin (HN) and Rattin (HNr), a rat homolog of HN, are short peptides with a cytoprotective action. In the present study, we aimed to evaluate whether endogenous HNr plays an antiapoptotic role in pituitary tumor cells. Thus, we used RNA interference based on short-hairpin RNA (shRNA) targeted to HNr (shHNr). A plasmid including

Source
peer_reviewed_research
DOI
10.1007/s10495-018-1444-0
PubMed
29352443
Open original source
2008Animal research

Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.

Content-verified record concerning Humanin: "Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation." Abstract excerpt: The structural and dynamical properties of Humanin, a small peptide with neuroprotective activity against the insults of the Alzheimer's disease-related genes and the neurotoxic amyloid peptide, are studied in two different environments by molecular dynamics simulation. In this study, we have performed comparative molecular dynamics simulations in the absence and in the presence of TFE. The result

Source
peer_reviewed_research
DOI
10.1080/07391102.2008.10507241
PubMed
18597547
Open original source
2008Animal research

The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.

Content-verified record concerning Humanin: "The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol." Abstract excerpt: We have examined the structure of two Humanin (HN) analog peptides, HNG and AGA-(C8R)HNG17, in the presence of sodium dodecylsulfate (SDS) and trifluoroethanol (TFE) using CD and sedimentation velocity. Both HNG and AGA-(C8R)HNG17 underwent complex conformational changes with increasing concentrations of SDS and TFE, in contrast to general trend of increasing alpha-helix with their concentration.

Source
peer_reviewed_research
DOI
10.2174/092986608784567555
PubMed
18537742
Open original source
2022Animal research

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

Content-verified record concerning Humanin: "Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice." Abstract excerpt: Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple organ failure. Several clinical and experimental studies have suggested that the glycocalyx is an early target of endothelial injury during an infection. Colivelin, a synthetic derivative of the mitochondrial peptide humanin, has displayed cytoprotective effects in oxidative conditions. In the current stud

Source
peer_reviewed_research
DOI
10.3389/fimmu.2022.984298
PubMed
36119052
Open original source
2026Animal research

Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.

Content-verified record concerning Humanin: "Altered placental expression of small humanin-like peptides in gestational diabetes mellitus." Abstract excerpt: Gestational diabetes mellitus (GDM) is characterized by maternal insulin resistance and hyperglycemia and has been associated with placental mitochondrial alterations. Small humanin-like peptides (SHLP1-6), encoded within the mitochondrial 16S rRNA region, have been described as mitochondria-derived peptides (MDPs) with reported cytoprotective and metabolic effects in experimental settings. Howeve

Source
peer_reviewed_research
DOI
10.48101/ujms.v131.14142
PubMed
42453115
Open original source
2018Animal research

Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus.

Content-verified record concerning Humanin: "Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus." Abstract excerpt: Humanin (MT-RNR2) is an endogenous polypeptide that is involved in many diseases, including T2DM. Gestational diabetes mellitus (GDM) is defined as hyperglycemia during pregnancy. The aim of this study was to evaluate serum humanin levels in women with or without GDM and to elucidate possible correlations with anthropometric parameters, metabolic parameters and the incidence of GDM. Eighty-four wo

Source
peer_reviewed_research
DOI
10.1080/09513590.2018.1482869
PubMed
29909696
Open original source
2025Animal research

Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.

Content-verified record concerning Humanin: "Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease." Abstract excerpt: Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels decline with age and in neurodegenerative diseases such as Alzheimer's disease (AD). This study aimed to evaluate whether blood and plasma gene expression and plasma protein levels of HN and MOTS-c are associated with AD markers, their role

Source
peer_reviewed_research
DOI
10.3390/ijms262210866
PubMed
41303353
Open original source
2017Animal research

Neuroprotective effect of G<sup>14</sup>-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.

Content-verified record concerning Humanin: "Neuroprotective effect of G<sup>14</sup>-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats." Abstract excerpt: Humanin (HN) has been identified to suppress neuron death. Gly 14 -HN (HNG), as a variant of HN, can decrease infarct volume after ischemia/reperfusion (I/R) injury. This study aimed to investigate the neuroprotective mechanism of HNG on global cerebral I/R (GI) in rats. Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time

Source
peer_reviewed_research
DOI
10.1080/01616412.2017.1352187
PubMed
28720038
Open original source
2010Animal research

Structure changes of natively disordered Humanin in the presence of lipid.

Content-verified record concerning Humanin: "Structure changes of natively disordered Humanin in the presence of lipid." Abstract excerpt: While neuroprotective activities of Humanin peptides have been clearly demonstrated, the functional mechanism has not been fully understood. Humanin and a majority of Humanin analogs showed a disordered structure at low peptide concentrations and aggregation at higher concentrations in aqueous solution at pH 7.0. Here we have examined the structure in lipid environments, i.e., in the presence of l

Source
peer_reviewed_research
DOI
10.1016/j.ijbiomac.2010.01.012
PubMed
20116397
Open original source
2026Animal research

Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.

Content-verified record concerning Humanin: "Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells." Abstract excerpt: Glucocorticoids, such as dexamethasone (DEXA), are effective therapeutics but cause severe muscle wasting. Mitochondrial-derived peptides (MDPs) are promising countermeasures, but their effectiveness is largely unexplored. We tested the hypothesis that the MDP S14G-humanin (HNG) and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) mitigate DEXA-induced atrophy in human skeletal myot

Source
peer_reviewed_research
DOI
10.14814/phy2.70791
PubMed
41732124
Open original source
2025Animal research

Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.

Content-verified record concerning Humanin: "Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality." Abstract excerpt: Humanin is the first short peptide in a speculated group of peptides produced by mitochondria that possess potent cytoprotective properties against various forms of stress. Despite being a prevalent peptide in testes and spermatozoa, there has been no report on the identification or quantification of humanin in buck sperm cells or the reproductive tract. This study aimed to establish the presence

Source
peer_reviewed_research
DOI
10.1111/rda.70113
PubMed
40838645
Open original source
2020Animal research

High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men.

Content-verified record concerning Humanin: "High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men." Abstract excerpt: Humanin is a small regulatory peptide encoded within the 16S ribosomal RNA gene ( MT-RNR2 ) of the mitochondrial genome that has cellular cyto- and metabolo-protective properties similar to that of aerobic exercise training. Here we investigated whether acute high-intensity interval exercise or short-term high-intensity interval training (HIIT) impacted skeletal muscle and plasma humanin levels. V

Source
peer_reviewed_research
DOI
10.1152/japplphysiol.00032.2020
PubMed
32271093
Open original source
2018Animal research

The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.

Content-verified record concerning Humanin: "The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells." Abstract excerpt: Endothelial dysfunction is fundamental to ischemic stroke and brain injury. The humanin analogue S14G-humanin (HNG) has been shown to be a cytoprotective derivative. In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro. In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-&#x3b1;

Source
peer_reviewed_research
DOI
10.1002/iub.1869
PubMed
29999240
Open original source
2013Animal research

Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.

Content-verified record concerning Humanin: "Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents." Abstract excerpt: Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3 binding, HNGF6A). 11-week-old male IGFBP-3(-/-) and wild type (WT) mice were div

Source
peer_reviewed_research
DOI
10.1210/en.2012-2004
PubMed
23836030
Open original source
2023Animal research

Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease.

Content-verified record concerning Humanin: "Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease." Abstract excerpt: Rationale: Mitochondrial dysfunction is a key factor in the pathogenesis of Parkinson's disease (PD). Accordingly, many aspects of mitochondrial function have been studied as a putative therapeutic target. Here we present a novel strategy to promote mitochondrial function and protect against Parkinson's disease by the peptide encoded within mitochondrial genome, mitochondria-derived peptide (MDP)

Source
peer_reviewed_research
DOI
10.7150/thno.84165
PubMed
37351170
Open original source
2005Animal research

Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

Content-verified record concerning Humanin: "Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection." Abstract excerpt: Humanin (HN) inhibits neuronal cell death induced by various Alzheimer's disease (AD)-related insults. It has been proposed that HN binds to a putative receptor on the cell membrane and triggers a signal transduction cascade linked to neuroprotection. Recently, it was shown that HN binds to pertussis toxin (PTX)-sensitive G protein-coupled formylpeptide receptor-like-1 molecule (FPRL-1), reduces A

Source
peer_reviewed_research
DOI
10.1016/j.lfs.2005.03.031
PubMed
16005025
Open original source
2023Animal research

A novel link between chronic inflammation and humanin regulation in children.

Content-verified record concerning Humanin: "A novel link between chronic inflammation and humanin regulation in children." Abstract excerpt: Children with inflammatory bowel disease (IBD) often suffer from poor bone growth and impaired bone health. Humanin is a cytoprotective factor expressed in bone and other tissues and we hypothesized that humanin levels are suppressed in conditions of chronic inflammation. To address this, humanin levels were analyzed in serum samples from IBD patients and in ex vivo cultured human growth plate tis

Source
peer_reviewed_research
DOI
10.3389/fendo.2023.1142310
PubMed
38322155
Open original source
2006Animal research

Zinc(II) binds to the neuroprotective peptide humanin.

Content-verified record concerning Humanin: "Zinc(II) binds to the neuroprotective peptide humanin." Abstract excerpt: The abnormal accumulation of the peptide amyloid-beta in the form of senile (or amyloid) plaques is one of the hallmarks of Alzheimer's disease (AD). Zinc ions have been implicated in AD and plaques formation. Recently, the peptide humanin has been discovered. Humanin showed neuroprotective activity against amyloid-beta insults. Here the question investigated is if humanin could interact directly

Source
peer_reviewed_research
DOI
10.1016/j.jinorgbio.2006.06.002
PubMed
16844225
Open original source
2007Animal research

Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.

Content-verified record concerning Humanin: "Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism." Abstract excerpt: S14G-humanin (S14G-HN) is one of the latest of a new family of neuropeptides with protective action against Alzheimer's disease insults. The structure of S14G-HN was studied with both spectroscopic techniques and molecular dynamics simulation. Secondary structure predictions and modeling of backbone conformation were carried out. Side chain reconstruction, homology modeling and molecular dynamics

Source
peer_reviewed_research
DOI
10.2174/092986607780989903
PubMed
17627606
Open original source
2018Animal research

Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.

Content-verified record concerning Humanin: "Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice." Abstract excerpt: Cardiac fibrosis is a biological process that increases with age and contributes to myocardial dysfunction. Humanin (HN) is an endogenous mitochondria-derived peptide that has cytoprotective effects and reduces oxidative stress. The present study aimed to test the hypothesis that chronic supplementation of exogenous HN in middle-aged mice could prevent and reverse cardiac fibrosis and apoptosis in

Source
peer_reviewed_research
DOI
10.1152/ajpheart.00685.2017
PubMed
30004252
Open original source
2021Animal research

The emerging role of mitochondrial derived peptide humanin in the testis.

Content-verified record concerning Humanin: "The emerging role of mitochondrial derived peptide humanin in the testis." Abstract excerpt: The discovery of mitochondrial derive peptides (MDPs) has spotlighted mitochondria as central hubs in control and regulation of cell viability and metabolism in the testis in response to intracellular and extracellular stresses. MDPs (Humanin, MOTS-c and SHLP-2) are present in testes. Humanin, the first MDP, is predominantly expressed in Leydig cells, and moderately in germ cells and seminal plasm

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130009
PubMed
34534645
Open original source
2020Animal research

Murine maternal dietary restriction affects neural Humanin expression and cellular profile.

Content-verified record concerning Humanin: "Murine maternal dietary restriction affects neural Humanin expression and cellular profile." Abstract excerpt: To understand the cellular basis for the neurodevelopmental effects of intrauterine growth restriction (IUGR), we examined the global and regional expression of various cell types within murine (Mus musculus) fetal brain. Our model employed maternal calorie restriction to 50% daily food intake from gestation day 10-19, producing IUGR offspring. Offspring had smaller head sizes with larger head:bod

Source
peer_reviewed_research
DOI
10.1002/jnr.24568
PubMed
31840315
Open original source
2007Animal research

Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.

Content-verified record concerning Humanin: "Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid." Abstract excerpt: Humanin is a short endogenous peptide, which can provide protection from cell death through its association with various receptors, including the pro-apoptotic Bcl-2 family proteins Bid, Bim, and Bax. By using NMR chemical shift mapping experiments, we demonstrate that the interaction between Humanin-derived peptides and Bid is specific, and we localize the binding site to a region on the surface

Source
peer_reviewed_research
DOI
10.1111/j.1747-0285.2007.00576.x
PubMed
17927731
Open original source
2014Animal research

IGF-I regulates the age-dependent signaling peptide humanin.

Content-verified record concerning Humanin: "IGF-I regulates the age-dependent signaling peptide humanin." Abstract excerpt: Aging is influenced by endocrine pathways including the growth hormone/insulin-like growth factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to the aging process, but the relevant mitochondrial signals mediating the effects of mitochondria are poorly understood. Humanin is a novel signaling peptide that acts as a potent regulator of cellular stress responses and protects from a v

Source
peer_reviewed_research
DOI
10.1111/acel.12243
PubMed
25040290
Open original source
2013Animal research

The emerging role of the mitochondrial-derived peptide humanin in stress resistance.

Content-verified record concerning Humanin: "The emerging role of the mitochondrial-derived peptide humanin in stress resistance." Abstract excerpt: The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also i

Source
peer_reviewed_research
DOI
10.1530/jme-12-0203
PubMed
23239898
Open original source
2021Animal research

Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.

Content-verified record concerning Humanin: "Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles." Abstract excerpt: Mitochondria was long thought to be an "end function" organelle that regulated the metabolic flux and apoptosis in the cell. However, with the discovery of&#xa0;the mitochondrial peptide (MDP) humanin (HN/MTRNR2), the cytoprotective and pro-survival applications of MDPs have taken the forefront of therapeutic and diagnostic research. However, the regulation of humanin-like MDPs in natural model sy

Source
peer_reviewed_research
DOI
10.1007/s10930-020-09944-7
PubMed
33387248
Open original source
2020Animal research

Assay Development and Measurement of the Aging Biomarker Humanin.

Content-verified record concerning Humanin: "Assay Development and Measurement of the Aging Biomarker Humanin." Abstract excerpt: Biomarkers that reflect aging could be used to target age-related diseases with precision and monitor treatment efficacy. One such biomarker is humanin, a 24-amino acid mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA gene. Humanin is measured in biological fluids, associates with many aging phenotypes, and attenuates aging in several animal models. In this chapter, we highl

Source
peer_reviewed_research
DOI
10.1007/978-1-0716-0592-9_18
PubMed
32410037
Open original source
2017Animal research

Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.

Content-verified record concerning Humanin: "Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells." Abstract excerpt: Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss and is characterized by progressive degeneration of the retina resulting in loss of central vision. The retinal pigment epithelium (RPE) is a critical site of pathology of AMD. Mitochondria and the endoplasmic reticulum which lie in close anatomic proximity to each other are targets of oxidative stre

Source
peer_reviewed_research
DOI
10.1155/2017/1675230
PubMed
28814984
Open original source
2019Animal research

Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

Content-verified record concerning Humanin: "Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment." Abstract excerpt: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modulate metabolism. By using a metabolomic approach, this study explores how the plasma metabolite profile is regulated in response to hu

Source
peer_reviewed_research
DOI
10.1007/s11306-019-1549-7
PubMed
31172328
Open original source
2001Animal research

Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

Content-verified record concerning Humanin: "Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults" Abstract excerpt: A novel factor, termed Humanin (HN), antagonizes against neurotoxicity by various types of familial Alzheimer's disease (AD) genes [V642I and K595N/M596L (NL) mutants of amyloid precursor protein (APP), M146L-presenilin (PS) 1, and N141I-PS2] and by Abeta1-43 with clear action specificity ineffective on neurotoxicity by polyglutamine repeat Q79 or superoxide dismutase 1 mutants. Here we report tha

Source
peer_reviewed_research
DOI
10.1523/jneurosci.21-23-09235.2001
PubMed
11717357
Open original source
2025Animal research

Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.

Content-verified record concerning Humanin: "Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis." Abstract excerpt: Oligoasthenozoospermia is a common cause of male infertility, for which effective treatments are urgently needed. Humanin (HN) is a peptide associated with this condition. To investigate the ameliorative effect of [Gly14]-Humanin (HNG) on oligoasthenozoospermia and the mechanisms. Mice were treated with cyclophosphamide (CP) to construct a mice model of oligoasthenozoospermia. The resulting model

Source
peer_reviewed_research
DOI
10.1111/andr.13786
PubMed
39435863
Open original source
2004Animal research

Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.

Content-verified record concerning Humanin: "Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide." Abstract excerpt: Podocyte alpha-actinin-4 (actinin-4) is an essential component of the glomerular filtration barrier. We recently reported that the central rod spectrin-like repeats (R1-R4) of actinin-4 have a high affinity to puromycin aminonucleoside (PAN), which can induce nephro-sis in animals. The aim of this study was to identify endogenous molecules that interact with the actinin-4 R1-R4 domain. To identify

Source
peer_reviewed_research
DOI
10.1007/s10157-004-0322-y
PubMed
15619032
Open original source
2023Animal research

Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.

Content-verified record concerning Humanin: "Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6." Abstract excerpt: Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these are encoded by sequences within the mitochondrial 12S and 16S ribosomal genes: humanin, MOTS-c, and the six SHLP peptides, SHLP1-SHLP6. These peptides have various effects in cell culture and animal models, affecting neuroprotection, insulin sensitivity, and apoptosis,

Source
peer_reviewed_research
DOI
10.1038/s41598-023-41053-0
PubMed
37644144
Open original source
2024Animal research

Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.

Content-verified record concerning Humanin: "Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches." Abstract excerpt: Mitochondrial dysfunction contributes to septic acute kidney injury (S-AKI), making mitochondrial protection a potential therapeutic strategy. This study investigates the effects of S14G-humanin (HNG) in S-AKI, utilizing 4D-label-free and parallel reaction monitoring (PRM) techniques for proteomic analysis. An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, f

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2024.150630
PubMed
39332154
Open original source
2019Animal research

Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.

Content-verified record concerning Humanin: "Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease." Abstract excerpt: Advanced chronic kidney disease (CKD) is characterized by a premature aging phenotype of multifactorial origin. Mitochondrial dysfunction is prevalent in CKD and has been proposed as a major contributor to poor muscle function. Although the mitochondria-derived peptides (MDPs) humanin and mitochondrial open reading frame of 12S rRNA-c (MOTS-c) are involved in cell survival, suppression of apoptosi

Source
peer_reviewed_research
DOI
10.1152/ajprenal.00202.2019
PubMed
31432706
Open original source
2011Animal research

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.

Content-verified record concerning Humanin: "VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin." Abstract excerpt: Humanin (HN) is a 24-residue peptide displaying a protective activity in vitro against a range of cytotoxic and neurotoxic insults, as well as mediating in vivo amelioration of Alzheimer disease (AD)-related memory impairment in experimental models. Published evidence suggests that the mechanisms through which HN exerts its cyto- and neuroprotective activity may include its secretion and binding t

Source
peer_reviewed_research
DOI
10.1096/fj.10-163535
PubMed
21393573
Open original source
2008Animal research

The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues

Content-verified record concerning Humanin: "The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues" Abstract excerpt: Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidinyl benzilate (QNB) in mice or rats in vivo using the Y-maze or multiple T-maze t

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2008.06.019
PubMed
18647630
Open original source
2025Animal research

Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.

Content-verified record concerning Humanin: "Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes." Abstract excerpt: This study investigated the effect of 8 weeks of high-intensity interval training (HIIT) on oxidative stress, inflammation, and apoptosis in rats with type 2 diabetes (T2D), focusing on the role of the Humanin (HN). In this study, 28 male Wistar rats were assigned to one of four groups: healthy control (CO), diabetes control (T2D), exercise (EX), and diabetes + exercise (T2D + EX). After diabetes

Source
peer_reviewed_research
DOI
10.1111/jcmm.70396
PubMed
39936487
Open original source
2016Animal research

Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.

Content-verified record concerning Humanin: "Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue." Abstract excerpt: Humanin comprising 24 amino acid residues is a bioactive peptide that has been isolated from the brain tissue of patients with Alzheimer's disease. Humanin reportedly suppressed aging-related death of various cells due to amyloid fibrils and oxidative stress. There are reports that the cytoprotective activity of Humanin was remarkably enhanced by optical isomerization of the Ser14 residue from l t

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2016.06.114
PubMed
27349871
Open original source
2026Animal research

Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).

Content-verified record concerning Humanin: "Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class)." Abstract excerpt: This study presents an in-depth analysis of an interactome comprising approximately 1033 nodes, focusing on its topology, reliability, and functional implications, with particular attention to the small mitochondrial proteins of the Humanin family and their nuclear-encoded MTRNR2Lx paralogs. The analysis, conducted through stringent high-reliability filters and experimentally supported interaction

Source
peer_reviewed_research
DOI
10.3390/biom16070981
PubMed
42509775
Open original source
2020Animal research

Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.

Content-verified record concerning Humanin: "Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration." Abstract excerpt: The mitochondrial-derived peptides (MDPs) are a new class of small open reading frame encoded polypeptides with pleiotropic properties. The prominent members are Humanin (HN) and small HN-like peptide (SHLP) 2, which encode 16S rRNA, while mitochondrial open reading frame of the twelve S c (MOTS-c) encodes 12S rRNA of the mitochondrial genome. While the multifunctional properties of HN and its ana

Source
peer_reviewed_research
DOI
10.1016/j.redox.2020.101663
PubMed
32768357
Open original source
2009Animal research

In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.

Content-verified record concerning Humanin: "In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives." Abstract excerpt: Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate (QNB)-induced impairment of spatial orientation and memory in rats, by employing

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2009.07.028
PubMed
19666070
Open original source
2006Animal research

The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.

Content-verified record concerning Humanin: "The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism." Abstract excerpt: The structure of a highly potent Ser14Gly analog of antiAlzheimer peptide, Humanin, was examined by circular dichroism (CD). The secondary structure is more disordered in water than in phosphate-buffered saline (PBS). The peptide structure in water is little dependent on both peptide concentration and temperature. On the contrary, the peptide structure was significantly different in PBS from the s

Source
peer_reviewed_research
DOI
10.1002/psc.773
PubMed
16835886
Open original source
2013Animal research

Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.

Content-verified record concerning Humanin: "Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin." Abstract excerpt: Inhibition of the early intracellular event that triggers neurodegenerative cascades and reversal of neuronal cell death are essential for effective treatment of Alzheimer's disease (AD). In this study, a novel therapeutic for AD, a transducible humanin with an extended caspase-3 cleavage sequence (tHN-C3), was developed and showed multiple mechanisms of therapeutic action. These included targeted

Source
peer_reviewed_research
DOI
10.1016/j.jconrel.2012.12.022
PubMed
23298615
Open original source
2022Animal research

Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.

Content-verified record concerning Humanin: "Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target." Abstract excerpt: The etiology of mild traumatic brain injury (mTBI) remains elusive due to the tissue and cellular heterogeneity of the affected brain regions that underlie cognitive impairments and subsequent neurological disorders. This complexity is further exacerbated by disrupted circuits within and between cell populations across brain regions and the periphery, which occur at different timescales and in spa

Source
peer_reviewed_research
DOI
10.1007/s00018-022-04495-9
PubMed
35951114
Open original source
2017Animal research

Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.

Content-verified record concerning Humanin: "Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness." Abstract excerpt: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard. Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins. The curren

Source
peer_reviewed_research
DOI
10.1016/j.jnci.2017.04.001
PubMed
28462847
Open original source
2021Animal research

The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.

Content-verified record concerning Humanin: "The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†." Abstract excerpt: Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell membrane receptor composed of glycoprotein 130 (gp130), IL-27 receptor subunit (IL-27R, also known as WSX-1/TCCR), and ciliary neuro

Source
peer_reviewed_research
DOI
10.1093/biolre/ioaa225
PubMed
33330922
Open original source
2013Animal research

Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.

Content-verified record concerning Humanin: "Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor." Abstract excerpt: Humanin is a secreted bioactive peptide that is protective in a variety of death models, including cell-based neuronal death models related to Alzheimer's disease (AD). To mediate the protective effect in AD-related death models, Humanin signals via a cell-surface receptor that is generally composed of three subunits: ciliary neurotrophic factor receptor &#x3b1;, WSX-1 and gp130 (heterotrimeric Hu

Source
peer_reviewed_research
DOI
10.1038/cddis.2013.80
PubMed
23519124
Open original source
2008Animal research

Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.

Content-verified record concerning Humanin: "Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog." Abstract excerpt: A 24-amino acid long peptide, Humanin, protects neurons from Alzheimer's disease (AD)-related cell toxicities at sub-nM-uM concentrations. Activity-dependent neurotrophic factor (ADNF) is a glia-derived neurotrophic peptide, which protects neurons from tetrodoxin treatment and AD-related and amyotrophic lateral sclerosis-related insults at fM concentrations. An attempt was made to further improve

Source
peer_reviewed_research
DOI
10.1002/psc.959
PubMed
17994638
Open original source
2018Animal research

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.

Content-verified record concerning Humanin: "Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin." Abstract excerpt: The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth. Endog deficiency induced reactive oxygen species (ROS) accumulation and abnormal growth in neonatal rodent cardiomyocytes, alte

Source
peer_reviewed_research
DOI
10.1016/j.redox.2018.02.021
PubMed
29502044
Open original source
2014Animal research

Apollon/Bruce is upregulated by Humanin.

Content-verified record concerning Humanin: "Apollon/Bruce is upregulated by Humanin." Abstract excerpt: Humanin, a short bioactive peptide, inhibits a variety of cell deaths. Humanin-mediated inhibition of neuronal cell death, caused by an Alzheimer's disease (AD)-linked mutant gene occurs via binding of Humanin to its heterotrimeric Humanin receptor (htHNR), which results in the activation of the Janus-associated kinases (JAKs) and signal transducer and activator and transcription 3 (STAT3) signali

Source
peer_reviewed_research
DOI
10.1007/s11010-014-2182-4
PubMed
25138702
Open original source
2026Animal research

Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.

Human measurement study in a defined population; associations cannot establish an intervention.

Source
peer_reviewed_research
DOI
10.1007/s40618-025-02747-6
PubMed
41186863
Open original source
2018Animal research

Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury.

Content-verified record concerning Humanin: "Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury." Abstract excerpt: Cardiac ischemia-reperfusion (I/R) injury has been shown to impair brain function. Humanin analogue (HNG) given prior to cardiac ischemia has been shown to attenuate both heart and brain mitochondrial dysfunction caused by cardiac I/R injury. In a clinical setting, patients received medical treatment for acute myocardial infarction either during or after the onset of myocardial ischemia; thus, in

Source
peer_reviewed_research
DOI
10.3233/jad-170708
PubMed
29376862
Open original source
2026Animal research

Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.

Content-verified record concerning Humanin: "Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy." Abstract excerpt: Duchenne muscular dystrophy (DMD) is a progressive muscle disease for which glucocorticoid (GC) treatment is standard therapy. Patients typically suffer from short stature and osteoporosis, caused by the underlying disease and adverse effects of GCs. We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of DMD.

Source
peer_reviewed_research
DOI
10.1016/j.bbrep.2025.102421
PubMed
41550496
Open original source
2026Animal research

Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.

Content-verified record concerning Humanin: "Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity." Abstract excerpt: Humanin is a mitochondrial-derived peptide with cytoprotective properties, but how it has evolved in response to different oxidative stress levels in mammals is not fully understood. This study examines how Humanin sequences have adapted to species-specific metabolic and environmental pressures. We compared the peptide in several mammalian species categorized by their distinct oxidative stress pro

Source
peer_reviewed_research
DOI
10.1016/j.freeradbiomed.2026.03.033
PubMed
41864362
Open original source
2026Animal research

Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.

Content-verified record concerning Humanin: "Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells." Abstract excerpt: Recent investigations show that mitochondrial impairment significantly contributes to endothelial damage in septic acute respiratory distress syndrome (ARDS). Humanin (HN) and its derivative Humanin-G (HNG) are mitochondrial polypeptides which have been identified as inhibitors of cellular apoptosis and neuroprotective agents against oxidative stress. This study aims to elucidate the effects of HN

Source
peer_reviewed_research
DOI
10.1093/ajrcmb/aanag079
PubMed
42153337
Open original source
2026Animal research

Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.

Content-verified record concerning Humanin: "Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model." Abstract excerpt: Diabetes mellitus is a major metabolic disorder closely associated with oxidative stress and male reproductive dysfunction. Humanin, a mitochondria-derived peptide, has been reported to exert cytoprotective, anti-apoptotic and antioxidant effects in various disease models; however, its role in diabetes-induced testicular damage remains unclear. This study aimed to investigate the effects of humani

Source
peer_reviewed_research
DOI
10.1113/ep093912
PubMed
42438323
Open original source
2026Animal research

Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.

Content-verified record concerning Humanin: "Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice." Abstract excerpt: Objective : Diabetes mellitus is closely associated with mitochondrial dysfunction, which disrupts cellular energy metabolism and perturbs hormonal homeostasis. Humanin (HN), a 24-amino acid peptide encoded within the mitochondrial genome, has attracted considerable attention due to its cytoprotective and metabolic regulatory properties. Despite its recognized biological potential, the role of HN

Source
peer_reviewed_research
DOI
10.3390/metabo16060373
PubMed
42346352
Open original source
2025Animal research

Humanin variants aggregate to produce different fibril morphologies.

Content-verified record concerning Humanin: "Humanin variants aggregate to produce different fibril morphologies." Abstract excerpt: Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX. The therapeutic benefits of HN have been well-documented, and administering humanin and related endogenous human peptides for treatment of disease, aging, and enhancement of athletic performance is becoming more widespread. However, very little is k

Source
peer_reviewed_research
DOI
10.1016/j.jbc.2025.110403
PubMed
40543583
Open original source
2025Animal research

Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.

Content-verified record concerning Humanin: "Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine." Abstract excerpt: Neuropathic pain is associated with diverse etiologies, including sciatica, diabetes, and the use of chemotherapeutic agents. Despite the varied origins, mitochondrial dysfunction, oxidative stress, and inflammatory cytokines are recognized as key contributing factors in both the initiation and maintenance of neuropathic pain. The effects of the mitochondrial-derived peptide humanin on neuropathic

Source
peer_reviewed_research
DOI
10.1016/j.neuropharm.2024.110207
PubMed
39510375
Open original source
2024Animal research

Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression.

Content-verified record concerning Humanin: "Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression." Abstract excerpt: The role of mitochondria peptides in the spreading of glioblastoma remains poorly understood. In this study, we investigated the mechanism underlying intracranial glioblastoma progression. Our findings demonstrate that the mitochondria-derived peptide, humanin, plays a significant role in enhancing glioblastoma progression through the intratumoral activation of the integrin alpha V (ITGAV)-TGF bet

Source
peer_reviewed_research
DOI
10.1038/s41419-024-06790-8
PubMed
38942749
Open original source
2024Animal research

Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model.

Content-verified record concerning Humanin: "Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model." Abstract excerpt: This study investigates the impact of chronic humanin (HN) treatment on pain-related markers (NMDA, substance P, TRPV1, and IL-1&#x3b2;) in diabetic mice's dorsal root ganglia (DRG). Additionally, we assess the effects of HN on cellular viability in DRG neurons. In vivo experiments involved 15&#xa0;days of HN administration (4 mg/kg) to diabetic mice ( n &#xa0;=&#xa0;10). Protein levels of NMDA, I

Source
peer_reviewed_research
DOI
10.1080/13813455.2024.2336922
PubMed
38599217
Open original source
2024Animal research

Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.

Content-verified record concerning Humanin: "Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology." Abstract excerpt: The APOE4 allele is recognized as a significant genetic risk factor to Alzheimer's disease (AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD even in advanced age. Humanin, a mitochondrial-derived peptide comprising 24 amino acids, has variants linked to cognitive resilience and longevity. Our research uncovered a unique humanin variant, P3S, specifically enri

Source
peer_reviewed_research
DOI
10.1111/acel.14153
PubMed
38520065
Open original source
2024Animal research

Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.

Content-verified record concerning Humanin: "Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease." Abstract excerpt: A commentary of the paper 'Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology' that appeared recently in Aging Cell. The possible association of a mitochondrial haplogroup with a disease is frequently discussed. The Humanin peptide encoded by the mtDNA has been shown to play an important regulatory role in cell metabolism. There are variant

Source
peer_reviewed_research
DOI
10.1111/acel.14207
PubMed
38757793
Open original source
2024Animal research

Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones.

Content-verified record concerning Humanin: "Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones." Abstract excerpt: Recent preclinical studies reported that the BCL-2 inhibitor venetoclax can impair bone growth. A strategy to prevent such a side effect of this promising anticancer drug is highly desired. Earlier in vitro and in vivo studies suggested that the mitochondrial peptide humanin has the potential to prevent drug-induced growth impairment. We hypothesized that co-treatment with the humanin analog HNG m

Source
peer_reviewed_research
DOI
10.1210/jendso/bvae009
PubMed
38328478
Open original source
2024Animal research

Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.

Content-verified record concerning Humanin: "Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms." Abstract excerpt: Background/Objectives : The severity of acute lung injury is significantly impacted by age and sex in patients with hemorrhagic shock. AMP-activated protein kinase (AMPK) is a crucial regulator of energy metabolism but its activity declines with aging. Humanin is a mitochondrial peptide that exerts cytoprotective effects in response to oxidative stressors and is associated with longevity. Using a

Source
peer_reviewed_research
DOI
10.3390/biomedicines12112615
PubMed
39595179
Open original source
2022Animal research

Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.

Content-verified record concerning Humanin: "Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats." Abstract excerpt: The potential to reproduce declines with age. Late-onset hypogonadism is characterized by reduced serum testosterone. Humanin is a mitochondrial-derived signaling peptide encoded by short open reading frames within the mitochondrial genome. It may protect against some age-related diseases such as atherosclerosis by its cytoprotective effects. The study aimed to investigate the potential anti-aging

Source
peer_reviewed_research
DOI
10.2174/1874467215666220127115602
PubMed
35086467
Open original source
2021Animal research

Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.

Content-verified record concerning Humanin: "Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway." Abstract excerpt: Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic and ovarian oxidative stress (OS) imbalance is a pivotal feature of PCOS. Humanin, a mitochondria-derived peptide, has been reported to function as an antioxidant in cardiomyocytes, pancreatic beta cells and other cells, bu

Source
peer_reviewed_research
DOI
10.1093/molehr/gaaa081
PubMed
33337472
Open original source
2021Animal research

Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.

Content-verified record concerning Humanin: "Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study." Abstract excerpt: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism and insulin resistance (IR); however, the pathogenesis of local ovarian IR in PCOS remains largely unclear. Humanin, a mitochondria-derived peptide, has been reported to be associated with IR. Our previous study confirmed that humanin is expressed in multiple cell

Source
peer_reviewed_research
DOI
10.1210/endocr/bqab056
PubMed
33693742
Open original source
2020Animal research

Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.

Content-verified record concerning Humanin: "Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis." Abstract excerpt: Prolonged use of glucocorticoids (GCs) for treatment of inflammatory and autoimmune conditions may have several negative side effects, such as impaired bone growth which has been linked to increased apoptosis in growth plate chondrocytes. It has recently been shown that humanin, a small mitochondrial derived peptide, rescues growth plate chondrocytes from GC-induced apoptosis. Our aim was to study

Source
peer_reviewed_research
PubMed
31172921
Open original source
2020Animal research

Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.

Content-verified record concerning Humanin: "Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome." Abstract excerpt: Cardiovascular disease (CVD) has been considered as a major risk factor of death in recent decades. In CVDs, the NLRP3 inflammasome is important for inflammatory response and vascular damage. Therefore, safe and effective treatments to decrease NLRP3 inflammasome activation are required. Increased levels of free fatty acid (FFA) have been associated with the progression of CVD. Humanin, a kind of

Source
peer_reviewed_research
DOI
10.1021/acsomega.0c01778
PubMed
32923762
Open original source
2019Animal research

Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.

Content-verified record concerning Humanin: "Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment." Abstract excerpt: Glucocorticoids (GCs) are frequently used to treat chronic disorders in children, including inflammation and cancer. Prolonged treatment with GCs is well known to impair bone growth, an effect linked to increased apoptosis and suppressed proliferation in growth plate chondrocytes. We hypothesized that the endogenous antiapoptotic protein humanin (HN) may prevent these effects. Interestingly, GC-in

Source
peer_reviewed_research
DOI
10.1096/fj.201801741r
PubMed
30657335
Open original source
2019Animal research

Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.

Content-verified record concerning Humanin: "Humanin levels in human seminal plasma and spermatozoa are related to sperm quality." Abstract excerpt: Humanin has reportedly been expressed in testis and spermatozoa, but no study has yet reported its presence in human seminal plasma (SP). The aim of this study was to investigate the presence of humanin in human SP and to determine the correlation between humanin levels in SP/spermatozoa and sperm quality. Semen samples for SP/sperm humanin level measurement were collected from 164 patients who at

Source
peer_reviewed_research
DOI
10.1111/andr.12614
PubMed
30920769
Open original source
2019Animal research

Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.

Content-verified record concerning Humanin: "Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration." Abstract excerpt: Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer's Disease through the suppression of inflammatory IL-6 cytokine receptors. Such receptors are found throughout the body, including the eye, suggesting its other potential applications. Age-related Macular Degeneration (AMD) is the leading cause of blindness in the developing world. There is no cure for t

Source
peer_reviewed_research
DOI
10.2174/1567201815666181031163111
PubMed
30381074
Open original source
2018Animal research

Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.

Content-verified record concerning Humanin: "Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells." Abstract excerpt: Mitochondrial dysfunction is associated with &#x3b2;-cell failure and insulin resistance in diabetes. Humanin is an endogenous cytoprotective peptide. In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic &#x3b2;-cells. Our findings demonstrated that Humanin treatment significantly increased the expression of PGC-1&#x3b1; and its downstream targe

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2018.02.071
PubMed
29432738
Open original source
2018Animal research

Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2.

Content-verified record concerning Humanin: "Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2." Abstract excerpt: Endothelial dysfunction and vascular complications induced by hyperglycemia play an important role in the pathological development of atherosclerosis in diabetes. Humanin, a 24-amino acid mitochondria-derived polypeptide, has displayed its cytoprotective effects in diverse cell types and tissues. In the current study, we aimed to characterize the effects of humanin on high glucose-induced endothel

Source
peer_reviewed_research
DOI
10.1016/j.molimm.2018.07.008
PubMed
30029058
Open original source
2018Animal research

Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.

Content-verified record concerning Humanin: "Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity." Abstract excerpt: The chemotherapeutic effect of doxorubicin (Dox) is limited by cumulative dose-dependent cardiotoxicity in cancer survivors. Dexrazoxane (DRZ) is approved to prevent Dox-induced cardiotoxicity. Humanin and its synthetic analog HNG have a cytoprotective effect on the heart. To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 ad

Source
peer_reviewed_research
DOI
10.1152/ajpheart.00155.2018
PubMed
29775411
Open original source
2017Animal research

Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.

Content-verified record concerning Humanin: "Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway." Abstract excerpt: Stroke, characterized by a disruption of blood supply to the brain, is a major cause of morbidity and mortality worldwide. Although humanin, a 24-amino acid polypeptide, has been identified to have multiple neuroprotective functions, the level of humanin in plasma has been demonstrated to decrease with age, which likely limits the effects against stroke injury. A potent humanin analogue, S14G-huma

Source
peer_reviewed_research
DOI
10.3892/etm.2017.4934
PubMed
29043002
Open original source
2016Animal research

Humanin: Functional Interfaces with IGF-I.

Content-verified record concerning Humanin: "Humanin: Functional Interfaces with IGF-I." Abstract excerpt: Humanin is the first newly discovered peptide encoded in the mitochondrial genome in over three decades. It is the first member of a novel class of mitochondrial derived peptides. This small, 24 amino acid peptide was initially discovered to have neuroprotective effects and subsequent experiments have shown that it is beneficial in a diverse number of disease models including stroke, cardiovascula

Source
peer_reviewed_research
DOI
10.1016/j.ghir.2016.03.005
PubMed
27082450
Open original source
2016Animal research

Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.

Content-verified record concerning Humanin: "Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model." Abstract excerpt: What is the central question of this study? Myocardial ischaemia-reperfusion (I/R) injury causes interference in the systemic circulation and damages not only the heart but also several vital organs, including the brain. Recently, a novel peptide called humanin has been shown to exert potent neuroprotective effects. However, the effect of humanin on the brain during cardiac I/R injury has not yet

Source
peer_reviewed_research
DOI
10.1113/ep085749
PubMed
27059110
Open original source
2016Animal research

Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.

Content-verified record concerning Humanin: "Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress." Abstract excerpt: Mitochondrial RNR-2 (mt-RNR2, humanin) has been shown to play a role in protecting several types of cells and tissues from the effects of oxidative stress. Humanin (HN) functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HN improved insulin sensitivity in animal models of diabetes mellitus but no clinical stud

Source
peer_reviewed_research
DOI
10.14814/phy2.12796
PubMed
27173674
Open original source
2015Animal research

Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.

Content-verified record concerning Humanin: "Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment." Abstract excerpt: [Gly14]-Humanin (HNG) is a 24-amino acid peptide which was first identified in the brains of patients diagnosed with Alzheimer's disease (AD). In this region, some neurons were protected against cell damage occurring in this disease. Further studies suggested a neuroprotective role for humanin against A&#x3b2; and some other insults. Intraventricularly administered streptozotocin (STZ) disrupts in

Source
peer_reviewed_research
DOI
10.1007/s12031-015-0531-8
PubMed
25744099
Open original source
2015Animal research

Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.

Content-verified record concerning Humanin: "Humanin Derivatives Inhibit Necrotic Cell Death in Neurons." Abstract excerpt: Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer's disease. Herein, we identify a novel function of the humanin-derivative AGA(C8R)-HNG17 (namely, protection against cellular necrosis). Necrosis is one of the main modes of cell death, which was until recently considered an unmoderated process. However, recent findings suggest the opposite.

Source
peer_reviewed_research
DOI
10.2119/molmed.2015.00073
PubMed
26062019
Open original source
2015Animal research

Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.

Content-verified record concerning Humanin: "Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β." Abstract excerpt: Nuclear translocation of IGFBP3 by importin-&#x3b2;1 is a prerequisite for IGFBP3-induced apoptosis. The neuroprotective peptide humanin (HN) counteracts IGFBP3-induced cell death. However, the mechanism by which humanin protects cells is currently unknown. The natural synthesis of this peptide decreases with age, coincident with the likelihood for the development of Alzheimer's Disease, making it

Source
peer_reviewed_research
DOI
10.2174/0929866522666150728114955
PubMed
26216267
Open original source
2014Animal research

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.

Content-verified record concerning Humanin: "Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor." Abstract excerpt: Excitatory neurotoxicity has been implicated in many pathological situations and there is no effective treatment available. Humanin is a 24-aa peptide cloned from the brain of patients with Alzheimer's disease (AD). In the present study, excitatory toxicity was induced by N-methyl-D-aspartate (NMDA) in primarily cultured rat cortical neurons. MTT assessment, lactate dehydrogenase (LDH) release, an

Source
peer_reviewed_research
DOI
10.1155/2014/341529
PubMed
24959608
Open original source
2011Animal research

Humanin signal for Alzheimer's disease.

Content-verified record concerning Humanin: "Humanin signal for Alzheimer's disease." Abstract excerpt: Despite a bulk of evidence supporting the idea that increased neurotoxic insults lead to Alzheimer's disease (AD), the possibility still remains that insufficiency of an endogenous defense system contributes to the disease progression. Humanin is a bioactive peptide that is likely to inhibit both neuronal death and dysfunction only related to AD by binding to a Humanin receptor on the cell-surface

Source
peer_reviewed_research
DOI
10.3233/jad-2011-102076
PubMed
21335658
Open original source
2010Animal research

Humanin and the receptors for humanin.

Content-verified record concerning Humanin: "Humanin and the receptors for humanin." Abstract excerpt: Alzheimer's disease (AD) is a prevalent dementia-causing neurodegenerative disease. Neuronal death is closely linked to the progression of AD-associated dementia. Accumulating evidence has established that a 24-amino-acid bioactive peptide, Humanin, protects neurons from AD-related neuronal death. A series of studies using various murine AD models including familial AD gene-expressing transgenic m

Source
peer_reviewed_research
DOI
10.1007/s12035-009-8090-z
PubMed
19997871
Open original source
2003Animal research

Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40

Content-verified record concerning Humanin: "Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40" Abstract excerpt: Humanin peptides (including HN, HNG and other mutants) were reported previously that antagonize neurotoxicity caused by various familial Alzheimer's disease (FAD) genes and Abeta derivatives. Herein, we describe the aggregation dynamics and the representative morphological characteristics of Abeta(1-40) after different time of addition humanin peptides, which revealed that (a) the interactions of

Source
peer_reviewed_research
DOI
10.1016/s0196-9781(03)00131-1
PubMed
12895653
Open original source
2011Animal research

[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].

Content-verified record concerning Humanin: "[Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]." Abstract excerpt: Humanin (HN) is a newly discovered 24-amino acid peptide, which may suppress neuronal cell death. HN cDNA includes the open reading frame (HN-ORF) of 75 bases, located 950 bases downstream of the 5' end of the HN cDNA. It was demonstrated that HN cDNA is 99% identical with mitochondrial DNA (mtDNA) sequence. HN homologues have been identified as expressed sequence tags (ESTs) in rat and nematode.

Source
peer_reviewed_research
PubMed
22010475
Open original source
2026Animal research

S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.

Content-verified record concerning Humanin: "S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis." Abstract excerpt: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with limited therapeutic options. S14G-humanin (HNG), a potent analog of humanin, exerts protective effects in various diseases, but its role in DN remains unexplored. DN was induced in C57BL/6 mice via high-fat diet and streptozotocin (STZ), with or without HNG treatment. Renal injury, necroptosis, and Z-DNA/ZBP1 pathways

Source
peer_reviewed_research
DOI
10.1016/j.ejphar.2026.179175
PubMed
42492881
Open original source
2026Animal research

S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.

Content-verified record concerning Humanin: "S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats." Abstract excerpt: Renal ischaemia-reperfusion (I/R) injury leads to acute tubular necrosis and renal failure, triggering pathological mechanisms including inflammation, reactive oxygen species generation, apoptosis and mitochondrial dysfunction. The mitochondrial peptide humanin (HN), known to possess anti-apoptotic and anti-inflammatory properties, has been shown to counteract oxidative stress and restore mitochon

Source
peer_reviewed_research
DOI
10.1113/ep094006
PubMed
42672739
Open original source
2025Animal research

S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.

Content-verified record concerning Humanin: "S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model." Abstract excerpt: Premature ovarian insufficiency (POI) is a major cause of female infertility, for which effective therapies remain limited. S14G-Humanin (HNG), a potent analogue of Humanin, exhibits strong antioxidant and anti-apoptotic properties and has demonstrated cytoprotective effects in various tissues, including the ovary. In this study, a cyclophosphamide (CP)-induced POI mouse model was established to e

Source
peer_reviewed_research
DOI
10.1093/molehr/gaaf042
PubMed
40811024
Open original source
2023Animal research

S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.

Content-verified record concerning Humanin: "S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice." Abstract excerpt: S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases. However, the specific pharmacological effects of HNG in heart failure (HF) have not been previously reported. Therefore, in this study, we aimed to investigate the potential protective effect of HNG in HF using a mouse model. HF was induced in mice

Source
peer_reviewed_research
DOI
10.1016/j.heliyon.2023.e21892
PubMed
38045183
Open original source
2023Animal research

S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.

Content-verified record concerning Humanin: "S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway." Abstract excerpt: Asthma is a chronic inflammatory disease with a high morbidity rate in children and significantly impacts their healthy growth. It is reported that Th2 cell-mediated airway inflammation and activated oxidative stress are involved in the pathogenesis of asthma. S14G-humanin (HNG) is a derivative of Humanin with higher activity. The present study proposes to explore the potential treating property o

Source
peer_reviewed_research
DOI
10.18632/aging.204874
PubMed
37451839
Open original source
2023Animal research

S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.

Content-verified record concerning Humanin: "S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB." Abstract excerpt: Acute lung injury (ALI) is characterized by severely damaged alveoli and blood vessels, seriously affecting the health of patients and causing a high mortality rate. The pathogenesis of ALI is complex, with inflammatory reactions and oxidative stress (OS) mainly involved. S14G humanin (HNG) is derived from humanin (HN), which is claimed with promising anti-inflammatory functions. Herein, the prote

Source
peer_reviewed_research
DOI
10.18632/aging.205267
PubMed
38054825
Open original source
2013Animal research

S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.

Content-verified record concerning Humanin: "S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein." Abstract excerpt: Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meo

Source
peer_reviewed_research
DOI
10.3969/j.issn.1673-5374.2013.27.009
PubMed
25206568
Open original source
2012Animal research

S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.

Content-verified record concerning Humanin: "S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice." Abstract excerpt: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by clinical cognitive decline and pathological deposition of amyloid-beta protein (A&#x3b2;) in the brain. So far, there has been no causative therapy for this devastating disease. S14G-Humanin (HNG), a synthetic derivative of Humanin (HN), has been shown to have strong neuroprotective ability against AD-related ins

Source
peer_reviewed_research
DOI
10.1016/j.pbb.2011.09.012
PubMed
21993310
Open original source
2018Animal research

Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.

Content-verified record concerning Humanin: "Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies." Abstract excerpt: To compare serum humanin concentrations in pregnant women with and without pre-eclampsia (PE). A case-control study where pregnant women (PE group, n = 37; control group, n = 34) studied through history parameters (gynecological, obstetrical, personal, and family), physical and sonographic examination parameters [body mass index (BMI), blood pressure obstetrical ultrasound], and biochemical/hormon

Source
peer_reviewed_research
DOI
10.1080/14767058.2017.1285885
PubMed
28110609
Open original source
2025Animal research

Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.

Content-verified record concerning Humanin: "Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study." Abstract excerpt: Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with an increased risk of cardiovascular disease (CVD), largely driven by peripheral endothelial dysfunction (ED). Humanin, a mitochondrial-derived peptide, has been suggested to play a protective role in endothelial function. However, the relationship between Humanin levels and ED in RA, as well as the interaction b

Source
peer_reviewed_research
DOI
10.3390/ncrna11010005
PubMed
39846683
Open original source
2020Animal research

HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.

Content-verified record concerning Humanin: "HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition." Abstract excerpt: The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer's disease. HNG, a humanin analogue, activates cell growth, proliferation, and cell cycle progression, and it protects cells f

Source
peer_reviewed_research
DOI
10.3390/ijms21124553
PubMed
32604799
Open original source
2024Animal research

[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.

Content-verified record concerning Humanin: "[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice." Abstract excerpt: Is there a protective effect of the humanin derivative [Gly14]-humanin (HNG) on a D-gal-induced mouse model of primary ovarian insufficiency (POI), and what is the underlying mechanism? D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model. Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks. Ovarian morphology, func

Source
peer_reviewed_research
DOI
10.1016/j.rbmo.2023.103330
PubMed
38163419
Open original source
2024Animal research

[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.

Content-verified record concerning Humanin: "[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6." Abstract excerpt: High glucose (HG) induced endothelial senescence is related to endothelial dysfunction and cardiovascular complications in diabetic patients. Humanin, a member of mitochondrial derived peptides (MDPs), is thought to contribute to aging-related cardiovascular protection. The goal of the study is to explore the pathogenesis of HG-induced endothelial senescence and potential anti-senescent effects of

Source
peer_reviewed_research
DOI
10.1038/s41598-024-81878-x
PubMed
39730568
Open original source
2022Animal research

[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.

Content-verified record concerning Humanin: "[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress." Abstract excerpt: Angiotensin II (AngII) is involved in the pathogenesis of hypertensive artery remodeling by inducing a phenotypic switch in vascular smooth muscle cells [Gly14]-Humanin (HNG), a humanin analogue, exerts potent cytoprotective effects both in vitro and in vivo . This study aimed to investigate the effects of HNG on an AngII-induced phenotypic switch in VSMCs and the potential mechanisms underlying t

Source
peer_reviewed_research
DOI
10.1177/09603271221136208
PubMed
36289015
Open original source
2021Animal research

[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.

Content-verified record concerning Humanin: "[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles." Abstract excerpt: Humanin, a newly emerging endogenously expressed cytoprotective peptide, has been shown to have anti-apoptotic properties effects by protecting neuronal cells injury. Endothelial microparticles (EMPs) are considered as vital mediators in intercellular communication. EMPs may regulate various physiological and pathological processes by transferring mRNAs and microRNAs (miRNAs) to recipient cells. E

Source
peer_reviewed_research
DOI
10.2147/dmso.s306026
PubMed
34079312
Open original source
2020Animal research

Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.

Content-verified record concerning Humanin: "Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders." Abstract excerpt: The mitochondria produce specific peptides-mitochondrial-derived peptides-that mediate the transcriptional stress response by their translocation into the nucleus and interaction with deoxyribonucleic acid. Mitochondrial-derived peptides are regulators of metabolism. This class of peptides comprises humanin, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c (MOTS-c) and

Source
peer_reviewed_research
DOI
10.1016/j.acvd.2020.03.020
PubMed
32680738
Open original source
2016Animal research

[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.

Content-verified record concerning Humanin: "[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats." Abstract excerpt: Alzheimer disease (AD), a progressive neurodegenerative disorder, is characterized by cognitive decline and the accumulation of senile plaques in the brain. Amyloid &#x3b2; protein (A&#x3b2;) in the plaques is thought to be responsible for the memory loss in AD patients. [Gly14]-humanin (HNG), a derivative of humanin (HN), has much stronger neuroprotective effects than natural HN in vitro. However

Source
peer_reviewed_research
DOI
10.1007/s12264-016-0041-x
PubMed
27306655
Open original source
2013Animal research

[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.

Content-verified record concerning Humanin: "[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage." Abstract excerpt: Perihematomal brain edema formation and consequent cell death contribute to second brain injury resulting in severe neurological deficits and sometimes delayed fatality after intracerebral hemorrhage (ICH). [Gly14]-Humanin (HNG), a variant of Humanin (HN) in which the 14th amino acid serine is replaced with glycine, reduced Alzheimer's disease-relevant insults and improved neurological deficits in

Source
peer_reviewed_research
DOI
10.1016/j.bbr.2013.03.023
PubMed
23538063
Open original source
2022Animal research

Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.

Content-verified record concerning Humanin: "Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition." Abstract excerpt: Alzheimer's disease (AD), Parkinson's disease (PD), and age-related macular degeneration (AMD) are common among neurodegenerative diseases, but investigations into novel therapeutic approaches are currently limited. Humanin (HN) is a mitochondrial-derived peptide found in brain tissues of patients with familial AD and has been increasingly investigated in AD and other neurodegenerative diseases. I

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2022.130097
PubMed
35104624
Open original source
2024Animal research

Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.

Content-verified record concerning Humanin: "Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice." Abstract excerpt: Male patients who undergo prepubertal chemotherapy face the dual problems of fertility preservation in adulthood, including low testosterone, hypersexual function, and infertility. Humanin, as a small polypeptide coded within the mitochondrial DNA, with the mitochondrial short open reading frame named MOTS-c, both was believed to regulate mitochondrial homeostasis, be anti-inflammatory, improve me

Source
peer_reviewed_research
DOI
10.1016/j.reprotox.2024.108674
PubMed
39079574
Open original source
2023Animal research

Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.

Content-verified record concerning Humanin: "Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage." Abstract excerpt: Loss of hair cells can lead to irreversible sensorineural hearing loss. Therefore, hair cell preservation is critical for hearing. Mitochondrial derived peptides (MDPs) are bioactive peptides and prominent members of this family are humanin (HN) and the mitochondrial-open-reading frame of the twelve S c (MOTS-c). The protective roles of HN and MOTS-c in age-related diseases and in various tissues

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2023.08.033
PubMed
37633181
Open original source
2022Animal research

Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).

Content-verified record concerning Humanin: "Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD)." Abstract excerpt: Inflammation plays a crucial role in the etiology and pathogenesis of AMD (Age-related Macular Degeneration). Humanin G (HNG) is a Mitochondrial Derived Peptide (MDP) that is cytoprotective in AMD and can protect against mitochondrial and cellular stress induced by damaged AMD mitochondria. The goal of this study was to test our hypothesis that inflammation-associated marker protein levels are inc

Source
peer_reviewed_research
DOI
10.18632/aging.204074
PubMed
35576057
Open original source
2017Animal research

High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.

Content-verified record concerning Humanin: "High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction." Abstract excerpt: Although the gold standard treatment for acute myocardial infarction is reperfusion therapy, reperfusion itself can cause myocardial damage via induction of cardiac mitochondrial dysfunction. This can lead to increased myocardial infarct size, arrhythmias, and left ventricular (LV) dysfunction. Recently, a newly discovered peptide, Humanin, has been shown to exert several beneficial effects includ

Source
peer_reviewed_research
DOI
10.1111/1755-5922.12289
PubMed
28726291
Open original source
2010Animal research

[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.

Content-verified record concerning Humanin: "[Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo." Abstract excerpt: The novel neuroprotective action of Humanin (HN), especially its derivative [Gly(14)]-humanin (HNG), against Alzheimer's disease (AD)-related insults has been reported. However, it is still short of electrophysiological evidence for the protection of HN on synaptic plasticity, and the molecular mechanisms that underlie the neuroprotective function of HN remain largely unknown. The present study ex

Source
peer_reviewed_research
DOI
10.1002/syn.20707
PubMed
19768812
Open original source
2004Animal research

Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.

Content-verified record concerning Humanin: "Effect of humanin analogues on experimentally induced impairment of spatial memory in rats." Abstract excerpt: Humanin and its analogues have been shown to protect cells against death induced by various Alzheimer's disease genes and amyloid-beta-peptides in vitro: the analogue [Gly14]-humanin has also been shown to be potent in reversing learning and memory impairment induced by scopolamine in mice in vivo. It is important to validate these results by using other behavioral methods. In this study, the effe

Source
peer_reviewed_research
DOI
10.1002/psc.569
PubMed
15526713
Open original source
2001Animal research

[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.

Content-verified record concerning Humanin: "[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo." Abstract excerpt: Humanin is a very recently discovered 24 amino acid linear polypeptide, which protects against cell death induced by either familial Alzheimer's disease mutant of amyloid precursor protein, presenilin-1 or presenilin-2 in vitro. However, it has remained uncertain whether humanin is a useful drug for the animal model of learning and memory deficit. In this study, we evaluated the effects of [Gly(14

Source
peer_reviewed_research
DOI
10.1038/sj.bjp.0704429
PubMed
11739234
Open original source
2024Animal research

Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).

Content-verified record concerning Humanin: "Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD)." Abstract excerpt: Advanced stages of Age-related Macular Degeneration (AMD) are characterized by retinal neurodegeneration and aberrant angiogenesis, and mitochondrial dysfunction contributes to the pathogenesis of AMD. In this study, we tested the hypothesis that Humanin G (HNG), a cytoprotective mitochondrial-derived peptide, positively regulates cell proliferation, cell death, and the protein levels of angiogene

Source
peer_reviewed_research
DOI
10.1016/j.mito.2023.11.001
PubMed
38029849
Open original source
2026Animal research

Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.

Content-verified record concerning Humanin: "Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy." Abstract excerpt: Amyloid beta (A&#x3b2;), a key component of drusen in age-related macular degeneration (AMD), induces oxidative stress, mitochondrial dysfunction, and degeneration in the retinal pigment epithelium (RPE), contributing to progressive vision loss in the elderly. We investigated the protective role of Humanin (HN), a mitochondria-derived peptide with known neuroprotective effects in A&#x3b2;-related

Source
peer_reviewed_research
DOI
10.1111/acel.70601
PubMed
42333946
Open original source
2024Animal research

Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.

Content-verified record concerning Humanin: "Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation." Abstract excerpt: Traumatic brain injury (TBI) often results in a reduction of the capacity of cells to sustain energy demands, thus, compromising neuronal function and plasticity. Here we show that the mitochondrial activator humanin (HN) counteracts a TBI-related reduction in mitochondrial bioenergetics, including oxygen consumption rate. HN normalized the disruptive action of TBI on memory function, and restored

Source
peer_reviewed_research
DOI
10.1016/j.bbadis.2023.166937
PubMed
37926362
Open original source
2022Animal research

Humanin derivative, HNG, enhances neurotransmitter release.

Content-verified record concerning Humanin: "Humanin derivative, HNG, enhances neurotransmitter release." Abstract excerpt: Humanin (HN) is an endogenous 24-residue peptide that was first identified as a protective factor against neuronal death in Alzheimer's disease (AD). We previously demonstrated that the highly potent HN derivative HNG (HN with substitution of Gly for Ser14) ameliorated cognitive impairment in AD mouse models. Despite the accumulating evidence on the antagonizing effects of HN against cognitive def

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2022.130204
PubMed
35843407
Open original source
2021Animal research

Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.

Content-verified record concerning Humanin: "Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases." Abstract excerpt: Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells, neurons, tissues against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as JAK/STAT pathway and interaction of BCL-2 family of protein. HN is an essential cytoprotective pep

Source
peer_reviewed_research
DOI
10.1016/j.lfs.2020.118679
PubMed
33130077
Open original source
2021Animal research

Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.

Content-verified record concerning Humanin: "Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD." Abstract excerpt: Humanin (HN) is an extensive neuroprotective peptide. This study aims to investigate the neuroprotective effects of HN on Calyculin A (CA)-induced neurotoxicities in cortical neurons and the underlying mechanism. CA was added into the cultured cortical neurons to induce neurotoxicity. Cortical neurons were preincubated with HN which plays a protective role. 3-(4,5-Dimethylthiazol-2-yl)-2,5-dipheny

Source
peer_reviewed_research
DOI
10.1080/00207454.2020.1769617
PubMed
32408779
Open original source
2020Animal research

Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.

Content-verified record concerning Humanin: "Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway." Abstract excerpt: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) remains unclear. Humanin (HN), a cytoprotective polypeptide, reportedly exhibits neuroprotective effects via suppression of inflammation and improvement of insulin resistance in neurons. This study aim was to investigate effects of HN on lipid accumulation in the hepatocytes and insulin signaling, and explore the underlying mechanisms.

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2020.03.128
PubMed
32245619
Open original source
2020Animal research

Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.

Content-verified record concerning Humanin: "Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer." Abstract excerpt: Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor pathogenesis is poorly understood. Here, we evaluated the effect of HN on the progression of experimental triple negativ

Source
peer_reviewed_research
DOI
10.1038/s41598-020-65381-7
PubMed
32444831
Open original source
2020Animal research

Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.

Content-verified record concerning Humanin: "Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers." Abstract excerpt: Members of the B-cell lymphoma (BCL-2) protein family regulate mitochondrial outer membrane permeabilization (MOMP), a phenomenon in which mitochondria become porous and release death-propagating complexes during the early stages of apoptosis. Pro-apoptotic BCL-2 proteins oligomerize at the mitochondrial outer membrane during MOMP, inducing pore formation. Of current interest are endogenous factor

Source
peer_reviewed_research
DOI
10.1074/jbc.ra120.013023
PubMed
33106313
Open original source
2020Animal research

Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.

Content-verified record concerning Humanin: "Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules." Abstract excerpt: HNG, a highly potent mutant of the anti-Alzheimer peptide-humanin, has been shown to protect against ischaemia-reperfusion (I/R) injury. However, the underlying mechanism related to platelet activation remains unknown. We proposed that HNG has an effect on platelet function and thrombus formation. In this study, platelet aggregation, granule secretion, clot retraction, integrin activation and adhe

Source
peer_reviewed_research
DOI
10.1111/jcmm.15151
PubMed
32174022
Open original source
2019Animal research

Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

Content-verified record concerning Humanin: "Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization." Abstract excerpt: The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2-associated X apoptosis regulator (BAX) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing mitochondrial outer-membrane permeabilization (MOMP). Of current interest are endogenous BAX ligands that inhibit its MO

Source
peer_reviewed_research
DOI
10.1074/jbc.ra119.011297
PubMed
31690630
Open original source
2018Animal research

Humanin is an endogenous activator of chaperone-mediated autophagy.

Content-verified record concerning Humanin: "Humanin is an endogenous activator of chaperone-mediated autophagy." Abstract excerpt: Chaperone-mediated autophagy (CMA) serves as quality control during stress conditions through selective degradation of cytosolic proteins in lysosomes. Humanin (HN) is a mitochondria-associated peptide that offers cytoprotective, cardioprotective, and neuroprotective effects in vivo and in vitro. In this study, we demonstrate that HN directly activates CMA by increasing substrate binding and trans

Source
peer_reviewed_research
DOI
10.1083/jcb.201606095
PubMed
29187525
Open original source
2018Animal research

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway.

Content-verified record concerning Humanin: "Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway." Abstract excerpt: Humanin (HN) is a novel 24-amino acid peptide that protects neurons against N-methyl-d-aspartate (NMDA)-induced toxicity. However, the contribution of the different mitogen-activated protein kinases (MAPKs) signals to HN neuroprotection against NMDA neurotoxicity remains unclear. The present study was therefore aimed to investigate neuroprotective mechanisms of HN. We analyzed intracellular Ca 2+

Source
peer_reviewed_research
DOI
10.3390/ijms19102982
PubMed
30274308
Open original source
2017Animal research

Humanin ameliorates diazepam-induced memory deficit in mice.

Content-verified record concerning Humanin: "Humanin ameliorates diazepam-induced memory deficit in mice." Abstract excerpt: Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect

Source
peer_reviewed_research
DOI
10.1016/j.npep.2016.10.008
PubMed
27814910
Open original source
2017Animal research

Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.

Content-verified record concerning Humanin: "Humanin affects object recognition and gliosis in short-term cuprizone-treated mice." Abstract excerpt: Humanin (HN) is a 24-residue peptide that manipulates cell survival under various stresses. A highly potent HN derivative, HNG, reduced amyloid burden and neuroinflammation and suppressed cognitive impairment in Alzheimer's disease model mice. Cuprizone (CPZ), a copper chelator, provokes demyelination in the central nervous system of mice. A shorter (one week) exposure to CPZ induces schizophrenia

Source
peer_reviewed_research
DOI
10.1016/j.npep.2017.10.002
PubMed
29070438
Open original source
2017Animal research

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.

Content-verified record concerning Humanin: "Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction." Abstract excerpt: N -methyl-D-aspartate (NDMA) receptor-mediated excitotoxicity has been implicated in a variety of pathological situations such as Alzheimer's disease (AD) and Parkinson's disease. However, no effective treatments for the same have been developed so far. Humanin (HN) is a 24-amino acid peptide originally cloned from the brain of patients with AD and it prevents stress-induced cell death in many cel

Source
peer_reviewed_research
DOI
10.2147/dddt.s133042
PubMed
28458518
Open original source
2017Animal research

Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.

Content-verified record concerning Humanin: "Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity." Abstract excerpt: The 24-residue peptide humanin (HN) has been proposed as a peptide-based inhibitor able to interact directly with amyloid-&#x3b2; (A&#x3b2;) oligomers and interfere with the formation and/or biological properties of toxic A&#x3b2; species. When administered exogenously, HN, or its synthetic S14G-derivative (HNG), exerted multiple cytoprotective effects, counteracting the A&#x3b2;-induced toxicity.

Source
peer_reviewed_research
DOI
10.3233/jad-160951
PubMed
28282805
Open original source
2016Animal research

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.

Content-verified record concerning Humanin: "Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione." Abstract excerpt: Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE) cells by HN in oxidative stress; however, the effect of HN on endoplasmic reticulum (ER) stress has not been evaluated in any cell type. Our aim here was to study the effect of HN on ER stress-induced apoptosis in RPE cells with a specific f

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0165150
PubMed
27783653
Open original source
2015Animal research

Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.

Content-verified record concerning Humanin: "Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats." Abstract excerpt: Humanin (HN) has cytoprotective action on male germ cells after testicular stress induced by heat and hormonal deprivation. To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP); or (iv) HN+CP. To investigate whether the protective effects of HN on germ cel

Source
peer_reviewed_research
DOI
10.1111/andr.12036
PubMed
25891800
Open original source
2010Animal research

Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.

Content-verified record concerning Humanin: "Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway." Abstract excerpt: The present study aimed to investigate the effects of humanin (HN) on primary cortical neuronal apoptosis induced by Abeta31-35, and explore the potential mechanisms. Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the n

Source
peer_reviewed_research
PubMed
20401442
Open original source
2014Animal research

Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.

Content-verified record concerning Humanin: "Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats." Abstract excerpt: Amyloid &#x3b2;-peptide (A&#x3b2;) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer's disease (AD). Humanin (HN) is a secretory peptide that inhibits the neurotoxicity of A&#x3b2;. However, the mechanism(s) by which HN exerts its neuroprotection against A&#x3b2;-induced AD-like pathological changes and memory deficits are yet to be completely defined. In the pre

Source
peer_reviewed_research
DOI
10.1007/s12264-014-1479-3
PubMed
25391447
Open original source
2012Animal research

Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.

Content-verified record concerning Humanin: "Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase." Abstract excerpt: The neuroprotective effects of superoxide dismutase (SOD) against hypoxia/reperfusion (I/R) injury and of humanin (HN) against toxicity by familial amyotrophic lateral sclerosis (ALS)-related mutant SOD led us to hypothesize that HN might have a role to increase the activity of SOD, which might be involved in the protective effects of HN on neuron against Alzheimer's disease-unrelated neurotoxicit

Source
peer_reviewed_research
DOI
10.1007/s11064-011-0593-0
PubMed
21935731
Open original source
2012Animal research

Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.

Content-verified record concerning Humanin: "Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice." Abstract excerpt: Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that has shown protective effects against atherosclerosis and is expressed in human vessels. However, its effects on the progression of kidney disease are unknown. We hypothesized that HN would protect the kidney in the early phase of atherogenesis. Forty-eight mice were studied in four groups (n=12 each). Twenty-four ApoE

Source
peer_reviewed_research
DOI
10.1016/j.lfs.2012.07.010
PubMed
22820173
Open original source
2012Animal research

Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.

Content-verified record concerning Humanin: "Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans." Abstract excerpt: The mechanism of atherosclerotic plaque progression leading to instability, rupture, and ischemic manifestation involves oxidative stress and apoptosis. Humanin (HN) is a newly emerging endogenously expressed cytoprotective peptide. Our goal was to determine the presence and localization of HN in carotid atherosclerotic plaques. Plaque specimens from 34 patients undergoing carotid endarterectomy w

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0031065
PubMed
22328926
Open original source
2011Animal research

Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.

Content-verified record concerning Humanin: "Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice." Abstract excerpt: Humanin (HN) is a cytoprotective peptide derived from endogenous mitochondria, expressed in the endothelial layer of human vessels, but its role in atherogenesis in vivo is not known. In vitro study, however, HN reduced oxidized low-density lipoprotein induced formation of reactive oxygen species and apoptosis. The present study tested the hypothesis that long term treatment with HN will have a pr

Source
peer_reviewed_research
DOI
10.1016/j.atherosclerosis.2011.06.038
PubMed
21763658
Open original source
2010Animal research

Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

Content-verified record concerning Humanin: "Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties" Abstract excerpt: Humanin (HN) is a newly discovered 24-amino acid peptide, which may suppress neuronal cell death. HN cDNA includes an open reading frame (HN-ORF) of 75 bases located 950 bases downstream of the 5' end of the HN cDNA. It has been demonstrated that HN cDNA is 99% identical to the mitochondrial DNA (mtDNA) sequence. HN homologs have been identified as expressed sequence tags (ESTs) in both rats and n

Source
peer_reviewed_research
DOI
10.1016/s1734-1140(10)70337-6
PubMed
21098860
Open original source
2010Animal research

Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.

Content-verified record concerning Humanin: "Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress." Abstract excerpt: Humanin (HN) is a 24-amino acid peptide that has been shown to have an anti-apoptotic function against neuronal cell death caused by Alzheimer's disease. Increased oxidative stress, one of the major factors contributing to this cell death, also plays an important role in the inflammatory process of atherosclerosis. The current study was designed to test the hypothesis that HN is expressed in the h

Source
peer_reviewed_research
DOI
10.1093/cvr/cvq191
PubMed
20562421
Open original source
2009Animal research

Humanin structural versatility and interaction with model cerebral cortex membranes.

Content-verified record concerning Humanin: "Humanin structural versatility and interaction with model cerebral cortex membranes." Abstract excerpt: Humanin (HN) is a recently identified neuroprotective peptide able to inhibit neurotoxicity induced by various insults which can be related to Alzheimer disease (AD) as well as to cell death induced by other stimuli. Previous CD and NMR studies demonstrated that HN adopts an unordered conformation in water, a alpha-helix conformation in 30% TFE, and a beta-sheet structure in PBS. Furthermore, othe

Source
peer_reviewed_research
DOI
10.1021/bi900187s
PubMed
19378954
Open original source
2009Animal research

Humanin: a novel central regulator of peripheral insulin action.

Content-verified record concerning Humanin: "Humanin: a novel central regulator of peripheral insulin action." Abstract excerpt: Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0006334
PubMed
19623253
Open original source
2009Animal research

Humanin; a defender against Alzheimer's disease?

Content-verified record concerning Humanin: "Humanin; a defender against Alzheimer's disease?" Abstract excerpt: Alzheimer's disease (AD) is the most prevalent neurological disease with dementia. AD-related dementia is caused by death and dysfunction of neurons involved in cognitive function. It has been generally believed that increased levels of toxic amyloid-betas (Abetas) are linked to the occurrence of neuronal death as well as dysfunction (Abeta cascade theory). Consequently, lowering levels of toxic A

Source
peer_reviewed_research
DOI
10.2174/157488909787002609
PubMed
19149712
Open original source
2006Animal research

Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia

Content-verified record concerning Humanin: "Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia" Abstract excerpt: We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease. Because HN was recently found to block proapoptotic Bax function and exert its versatile cytoprotective effects in association with an increase in ATP levels, HN expression may thu

Source
peer_reviewed_research
DOI
10.1007/s10038-006-0397-2
PubMed
16639504
Open original source
2006Animal research

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.

Content-verified record concerning Humanin: "Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis." Abstract excerpt: Humanin (HN), a 24-amino-acid neuroprotective peptide, was originally found in the occipital lobe of an autopsied Alzheimer's disease (AD) patient. HN inhibits neuronal death by binding to its specific receptor on the cell membrane and triggering a Jak2/STAT3 prosurvival pathway. The activation of this pathway may represent a therapeutic approach to AD. HN also exhibits neuroprotective activity ag

Source
peer_reviewed_research
DOI
10.1111/j.1527-3458.2006.00113.x
PubMed
16958985
Open original source
2005Animal research

Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches

Content-verified record concerning Humanin: "Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches" Abstract excerpt: Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal-dominant neurodegenerative disorder caused by expansion of CAG repeats in the DRPLA gene, which codes for a polyglutamine (polyQ) stretch. The expanded polyQs are known to form intracellular aggregates and to confer neurotoxic activity. Recent studies have indicated that activation of apoptosis signal-regulating kinase 1 (ASK1) is involv

Source
peer_reviewed_research
DOI
10.1385/jmn:25:2:165
PubMed
15784964
Open original source
2004Animal research

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.

Content-verified record concerning Humanin: "Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin." Abstract excerpt: The 24-residue peptide Humanin (HN) protects neuronal cells from insults of various Alzheimer's disease (AD) genes and Abeta by forming a homodimer. We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Peptides, 24, 585-595]. Here we examined whether any of

Source
peer_reviewed_research
DOI
10.1111/j.0953-816x.2004.03298.x
PubMed
15128389
Open original source
2004Animal research

Humanin: After the Discovery

Content-verified record concerning Humanin: "Humanin: After the Discovery" Abstract excerpt: Humanin (HN) is a novel neuroprotective factor that consists of 24 amino acid residues. HN suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults, including both amyloid-beta (betaAbeta) peptides and familial AD-causative genes. Cerebrovascular smooth muscle cells are also protected from Abeta toxicity by HN, suggesting that HN affects both neuronal and non-neuronal cel

Source
peer_reviewed_research
DOI
10.1385/mn:30:3:327
PubMed
15655255
Open original source
2004Animal research

Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

Content-verified record concerning Humanin: "Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor." Abstract excerpt: Alzheimer's disease (AD) is characterized by overproduction of beta amyloid peptides in the brain with progressive loss of neuronal cells. The 42-aa form of the beta amyloid peptide (Abeta(42)) is implied as a major causative factor, because it is toxic to neurons and elicits inflammatory responses in the brain by activating microglial cells. Despite the overproduction of Abeta(42), AD brain tissu

Source
peer_reviewed_research
DOI
10.4049/jimmunol.172.11.7078
PubMed
15153530
Open original source
2003Animal research

Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity

Content-verified record concerning Humanin: "Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity" Abstract excerpt: Cerebral amyloid beta-protein (Abeta) angiopathy (CAA) is a key pathological feature of Alzheimer's disease (AD) and related disorders. We have used human cerebrovascular smooth muscle (HCSM) cells as an in vitro model system to investigate the pathogenic mechanisms of the pathology of CAA. It was previously demonstrated that certain pathogenic forms of Abeta induce several pathologic responses in

Source
peer_reviewed_research
DOI
10.1046/j.1471-4159.2003.01524.x
PubMed
12558989
Open original source
2013Animal research

A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.

Content-verified record concerning Humanin: "A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts." Abstract excerpt: A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia-reperfusion (MI-R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activation of antioxidant defense mechanisms leading to preservation of mitochondrial

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2013.08.055
PubMed
23985350
Open original source
2010Animal research

Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.

Content-verified record concerning Humanin: "Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice." Abstract excerpt: Humanin (HN), an endogenous antiapoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion. Male C57BL6/J mice (8 to 10 week old) were subjected to 45 minutes of left coronary artery occlusion followed by a 24-hour rep

Source
peer_reviewed_research
DOI
10.1161/atvbaha.110.205997
PubMed
20651283
Open original source
2011Animal research

A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.

Content-verified record concerning Humanin: "A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice." Abstract excerpt: Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including exposure to amyloid beta (Abeta), in vitro. We previously demonstrated that the injection of S14G-HN, a highly potent HN derivative, into brain ameliorated memory loss in an Abeta-injection mous

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0016259
PubMed
21264226
Open original source
2005Animal research

A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice

Content-verified record concerning Humanin: "A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice" Abstract excerpt: Humanin (HN) is a 24-amino acid peptide that protects neuronal cells from death caused by Alzheimer's disease (AD)-related genes and amyloid-beta (Abeta). Multiple studies have revealed its biochemical and neuroprotective characteristics in vitro; however, little has been known regarding whether HN is effective in vivo in AD model systems. We examined the effect of S14G-HN, a 1,000-fold more poten

Source
peer_reviewed_research
DOI
10.1002/jnr.20391
PubMed
15678515
Open original source
2020Animal research

The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.

Content-verified record concerning Humanin: "The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress." Abstract excerpt: Humanin (HN) is a hydrophobic 24-amino acid peptide derived from mitochondrial DNA that modulates cellular responses to oxidative stress and protects human retinal pigment epithelium (RPE) cells from apoptosis. To solubilize HN, this report describes two genetically-encoded fusions between HN and elastin-like polypeptides (ELP). ELPs provide steric stabilization and/or thermo-responsive phase sepa

Source
peer_reviewed_research
DOI
10.1016/j.nano.2019.102111
PubMed
31655204
Open original source
2020Animal research

[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.

Content-verified record concerning Humanin: "[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs." Abstract excerpt: Abnormal aggregation of oxidized low-density lipoprotein (Ox-LDL) in vascular endothelial cells (VECs) is one of the major pathological changes in atherosclerotic lesions. Our research aimed to assess the mechanism of humanin (HN) in promoting autophagic degradation of Ox-LDL in HUVECs. Flow cytometry and lipid quantitation results showed that Ox-LDL caused lipid and cholesterol accumulation in HU

Source
peer_reviewed_research
DOI
10.1016/j.numecd.2020.07.022
PubMed
32917500
Open original source
2019Animal research

The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.

Content-verified record concerning Humanin: "The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma." Abstract excerpt: Subfertility is a major concern of long-term cancer survivors at the reproductive age. We have previously demonstrated that a potent humanin analogue, HNG, protected chemotherapy-induced apoptosis in germ cells but not cancer cells in a metastatic melanoma allograft model. In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of

Source
peer_reviewed_research
DOI
10.1016/j.yexmp.2019.104261
PubMed
31085184
Open original source
2015Animal research

Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.

Content-verified record concerning Humanin: "Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production." Abstract excerpt: Evidence for the putative mitochondrial origin of the Humanin (HN) peptide has been lacking, although its cytoprotective activity has been demonstrated in a variety of organismal and cellular systems. We sought to establish proof-of-principle for a mitochondria-derived peptide (MDP) in a rat-derived cellular system as the rat HN sequence is predicted to lack nuclear insertions of mitochondrial ori

Source
peer_reviewed_research
DOI
10.1016/j.mce.2015.06.015
PubMed
26116236
Open original source
2018Animal research

S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.

Content-verified record concerning Humanin: "S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse." Abstract excerpt: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by A&#x3b2; plaque deposition in the brain, which is related to the disorder of autophagosome maturation, transport, and formation of autolysosome. Notably, abnormal insulin signaling is connected with cognitive dysfunction in AD. In this study, using APP/PS1 transgenic mice as AD model, we investigated the mechanism

Source
peer_reviewed_research
DOI
10.1002/jcb.26452
PubMed
29058763
Open original source
2020Animal research

Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.

Content-verified record concerning Humanin: "Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults." Abstract excerpt: Humanin (HN) is a 24-amino acid mitochondrial-derived peptide, best known for its ability to protect neurons from damage caused by ischemic stroke and neurodegenerative insults and cardiomyocytes from myocardial infarction or doxorubicin (Dox)-induced cardiotoxicity. This study examines the neuroprotective and myoprotective effects of HN novel synthetic analogs HUJInin and c(D-Ser14-HN), prepared

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2020.170399
PubMed
32889021
Open original source
2019Animal research

Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage.

Content-verified record concerning Humanin: "Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage." Abstract excerpt: This study was aimed to investigate the protective effect of potent humanin analogue (HNG) supplementation to freezing media on freezing-thawing induced human sperm damage. We collected semen samples with normal sperm parameters from 15 healthy men. After the swim-up processing, the motile spermatozoa from each of the men were allocated to four equal groups: In the control group, the spermatozoa w

Source
peer_reviewed_research
DOI
10.1016/j.cryobiol.2019.04.001
PubMed
30959025
Open original source
2018Animal research

Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP.

Content-verified record concerning Humanin: "Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP." Abstract excerpt: Myxomatous mitral valve disease (MMVD) is a cardiac condition commonly found in older dogs. The disease process can lead to heart failure (HF). In HF, an increase of reactive oxygen species (ROS) and abnormal mitochondrial activity, as well as apoptosis, have been reported. Humanin (HN) is a polypeptide that has a cardioprotective effect against apoptosis and oxidative stress. The purposes of this

Source
peer_reviewed_research
DOI
10.24425/124305
PubMed
30605282
Open original source
2013Animal research

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.

Content-verified record concerning Humanin: "Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell." Abstract excerpt: Humanin (HN) is a 24-aa polypeptide that offers protection from Alzheimer's disease and myocardial infarction, increases insulin sensitivity, improves survival of &#x3b2; cells, and delays onset of diabetes. Here we examined the acute effects of HN on insulin secretion and potential mechanisms through which they are mediated. Effects of a potent HN analog, HNGF6A, on glucose-stimulated insulin sec

Source
peer_reviewed_research
DOI
10.1096/fj.13-231092
PubMed
23995290
Open original source
2013Animal research

[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.

Content-verified record concerning Humanin: "[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice." Abstract excerpt: Humanin (HN) has been identified as an endogenous peptide that inhibited AD-relevant neuronal cell death. HNG, a variant of HN in which the 14th amino acid serine was replaced with glycine, can reduce infarct volume and improve neurological deficits after ischemia/reperfusion injury. In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and ex

Source
peer_reviewed_research
DOI
10.1016/j.neuroscience.2012.11.019
PubMed
23178909
Open original source
2012Animal research

[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].

Content-verified record concerning Humanin: "[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats]." Abstract excerpt: Amyloid &#x3b2; protein (A&#x3b2;) is closely involved in the pathogenesis of Alzheimer's disease (AD), and one of the main strategies for AD treatment is antagonizing the neurotoxicity of A&#x3b2; or even clearing the A&#x3b2; deposited in the brain. The present study was aimed to observe the effects of intrahippocampal injection of A&#x3b2;&#x2083;&#x2081;&#x208b;&#x2083;&#x2085; on the spatial

Source
peer_reviewed_research
PubMed
23258324
Open original source
2017Animal research

Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.

Content-verified record concerning Humanin: "Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats." Abstract excerpt: The excessive apoptosis of intestinal epithelial cells (IECs) partly accounts for the development of colonic inflammation and eventually results in ulcerative colitis (UC). Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. The present study aimed to investigate the effects of glysin variant of humanin

Source
peer_reviewed_research
DOI
10.4103/sjg.sjg_318_16
PubMed
28361841
Open original source
2022Animal research

The role of humanin in natural stress tolerance: An underexplored therapeutic avenue.

Content-verified record concerning Humanin: "The role of humanin in natural stress tolerance: An underexplored therapeutic avenue." Abstract excerpt: The discovery of humanin (HN/MTRNR2) 20&#xa0;years ago blazed a trail to identifying mitochondrial derived peptides with biological function. Humanin is associated with pro-survival, cytoprotective, anti-inflammatory, and anti-oxidative properties and may play a role in reducing neurodegenerative and metabolic disease progression. Although the role of humanin in vitro and in vivo laboratory models

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130022
PubMed
34626747
Open original source
2022Animal research

The role of humanin in the regulation of reproduction.

Content-verified record concerning Humanin: "The role of humanin in the regulation of reproduction." Abstract excerpt: Humanin, a mitochondria-derived peptide, has been found to exert variously protective function in many tissues, especially in the nervous tissues. However, relatively limited studies have focused on the role of humanin in the regulation of reproduction. Current observations indicate that humanin plays an important role in regulating the response of the cell to oxidative stress and apoptosis in ova

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130023
PubMed
34626748
Open original source
2016Animal research

Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.

Content-verified record concerning Humanin: "Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors." Abstract excerpt: Rubimetide (Met-Arg-Trp), which had been isolated as an antihypertensive peptide from an enzymatic digest of spinach ribulose-bisphosphate carboxylase/oxygenase (Rubisco), showed anxiolytic-like activity prostaglandin (PG) D2-dependent manner in the elevated plus-maze test after administration at a dose of 0.1mg/kg (ip.) or 1mg/kg (p.o.) in male mice of ddY strain. In this study, we found that rub

Source
peer_reviewed_research
DOI
10.1016/j.peptides.2016.07.001
PubMed
27475912
Open original source
2013Animal research

Circulating humanin levels are associated with preserved coronary endothelial function.

Content-verified record concerning Humanin: "Circulating humanin levels are associated with preserved coronary endothelial function." Abstract excerpt: Humanin is a small endogenous antiapoptotic peptide, originally identified as protective against Alzheimer's disease, but subsequently also found on human endothelium as well as carotid artery plaques. Endothelial dysfunction is a precursor to the development of atherosclerotic plaques, which are characterized by a highly proinflammatory, reactive oxygen species, and apoptotic milieu. Previous ani

Source
peer_reviewed_research
DOI
10.1152/ajpheart.00765.2012
PubMed
23220334
Open original source
2014Animal research

Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog.

Content-verified record concerning Humanin: "Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog." Abstract excerpt: We have previously shown that the structural stability of humanin&#xa0;(HN), a neuroprotective peptide ligand, is one of the attributes to the observed activity differences between HN analogs. It has been observed that the activity increased consecutively in the S7A&#x2011;HN analog, the parent HN and the S14G&#x2011;HN analog, consistent with the increased stability observed in that order. In the

Source
peer_reviewed_research
DOI
10.3892/mmr.2013.1797
PubMed
24247787
Open original source
2022Animal research

An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls.

Content-verified record concerning Humanin: "An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls." Abstract excerpt: Buffalo spermatozoa are vulnerable to cryo-injuries due to inherent deficiency of endogenous antioxidants, high polyunsaturated fatty acids (PUFA) content in plasma membrane and low cholesterol/phospholipid (C/P) ratio. Humanin is a potent cytoprotective agent that protects the cells against oxidative stress and apoptosis. The present study was designed to establish the presence of Humanin in buff

Source
peer_reviewed_research
DOI
10.1016/j.theriogenology.2022.09.013
PubMed
36183493
Open original source
2015Animal research

The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.

Content-verified record concerning Humanin: "The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs." Abstract excerpt: Human (HN) prevents stress-induced apoptosis in many cells/tissues. In this study we showed that HN ameliorated chemotherapy [cyclophosphamide (CP) and Doxorubicin (DOX)]-induced male germ cell apoptosis both ex vivo in seminiferous tubule cultures and in vivo in the testis. HN acts by several putative mechanisms via binding to: an IL-12 like trimeric membrane receptor; BAX; or insulin-like growth

Source
peer_reviewed_research
DOI
10.1007/s10495-015-1105-5
PubMed
25666707
Open original source
2019Animal research

Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.

Content-verified record concerning Humanin: "Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study." Abstract excerpt: Is humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)? Follicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian tissues were collected from two

Source
peer_reviewed_research
DOI
10.1016/j.rbmo.2018.11.002
PubMed
30503199
Open original source
2022Animal research

Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls.

Content-verified record concerning Humanin: "Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls." Abstract excerpt: Cryopreservation process negatively affects spermatozoa functions. Humanin, a small polypeptide encoded in the mitochondrial genome, is well known for its role in cell survival. To quantify the endogenous levels of humanin in seminal plasma of crossbred Frieswal bulls and to study its role in cryoprotection. The presence of humanin in bull spermatozoa was also investigated. A total of 40 semen sam

Source
peer_reviewed_research
DOI
10.54680/fr22510110712
PubMed
36626132
Open original source
2016Animal research

Potential Roles of Humanin on Apoptosis in the Heart.

Content-verified record concerning Humanin: "Potential Roles of Humanin on Apoptosis in the Heart." Abstract excerpt: The process of programmed cell death, or apoptosis, is known as a key player in the development and progression of cardiovascular disease. The proposed mechanism for apoptosis is the activation of two main apoptotic signaling pathways (the extrinsic and intrinsic pathways), which lead to cell death. As the rate and amount of cardiomyocyte loss is the most important determinant of patient morbidity

Source
peer_reviewed_research
DOI
10.1111/1755-5922.12168
PubMed
26667157
Open original source
2015Animal research

Central effects of humanin on hepatic triglyceride secretion.

Content-verified record concerning Humanin: "Central effects of humanin on hepatic triglyceride secretion." Abstract excerpt: Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimer's disease-associated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown previously that HN improves whole body glucose homeostasis by improving insulin sensitivity and increasing glucose-stimulated insulin secretion (GSIS

Source
peer_reviewed_research
DOI
10.1152/ajpendo.00043.2015
PubMed
26058861
Open original source
2011Animal research

Structure of three Humanin peptides with different activities upon interaction with liposome.

Content-verified record concerning Humanin: "Structure of three Humanin peptides with different activities upon interaction with liposome." Abstract excerpt: We have recently shown that a 24 amino acid Humanin (HN) adopts an anti-parallel &#x3b2;-sheet structure in the presence of a negatively charged 1,2-dioleoyl-sn-glycero-3-phosphoglycerol (DOPG) and suggested a possibility that it interacts with lipid membranes and thereby exerts neuroprotective effects through the target cell surface receptors or the intracellular signaling molecules following mem

Source
peer_reviewed_research
DOI
10.1016/j.ijbiomac.2010.12.017
PubMed
21215775
Open original source
2010Animal research

[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].

Content-verified record concerning Humanin: "[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis]." Abstract excerpt: To investigate the effect of [Gly14]-Humanin overexpression on Abeta(25-35);-induced PC12 cell apoptosis. Recombinant plasmid pcDNA3.1(-)/HNG-FLAG was transfected into PC12 cells by liposome method. The subclone cell lines were obtained by persistent G418 selection. The HNG gene expression of PC12 cells was detected by immunocytochemistry. After being treated with 25 micromol/L Abeta(25-35); for 2

Source
peer_reviewed_research
PubMed
20423647
Open original source
2023Animal research

Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.

Content-verified record concerning Humanin: "Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects." Abstract excerpt: Coronavirus Disease 2019 (COVID-19) is a life-threatening and persistent pandemic with high rates of mortality and morbidity. Although a dysfunction in the mitochondria occurs in COVID-19 pathogenesis, the contribution of mitochondrial-derived peptides to its pathophysiology has not yet been completely elucidated. The goals of this research were to assess the circulating humanin and mitochondrial

Source
peer_reviewed_research
DOI
10.2174/1389203724666230217101202
PubMed
36799414
Open original source
2015Animal research

The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.

Content-verified record concerning Humanin: "The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus." Abstract excerpt: Diabetes mellitus (DM) is associated with a loss of renal and vascular protection in women compared with men, but the responsible mechanisms are unclear. Recent experimental work implicated humanin (HN) as a novel cytoprotective hormone in DM. Our goal was to measure sex-related differences in HN levels in uncomplicated type 1 DM patients (T1D) and healthy controls (HC), as well as the interaction

Source
peer_reviewed_research
DOI
10.1139/cjpp-2014-0401
PubMed
25615723
Open original source
2014Animal research

Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.

Content-verified record concerning Humanin: "Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis." Abstract excerpt: Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has antiapoptotic action. In the present work, we demonstrated by immunocytochemical analysis and flow cytometry the expression of HNr in the anterior pituitary of female and male ad

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0111548
PubMed
25360890
Open original source
2023Animal research

PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.

Content-verified record concerning Humanin: "PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS." Abstract excerpt: Introduction: Despite therapeutic advances in hemorrhagic shock, mortality from multiple organ failure remains high. We previously showed that the &#x3b1;1 subunit of AMP-activated protein kinase (AMPK), a crucial regulator of mitochondrial function, exerts a protective role in hemorrhagic shock. Humanin is a mitochondrial peptide with cytoprotective properties against cellular stress. Here, we in

Source
peer_reviewed_research
DOI
10.1097/shk.0000000000002134
PubMed
37079467
Open original source
2019Animal research

Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y).

Content-verified record concerning Humanin: "Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y)." Abstract excerpt: The extensive usage of silver nanoparticles (AgNPs) as medical products such as antimicrobial and anticancer agents has raised concerns about their harmful effects on human beings. AgNPs can potentially induce oxidative stress and apoptosis in cells. However, humanin (HN) is a small secreted peptide that has cytoprotective and neuroprotective cellular effects. The aim of this study was to assess t

Source
peer_reviewed_research
DOI
10.3390/ijms20184439
PubMed
31505887
Open original source
2014Animal research

Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.

Content-verified record concerning Humanin: "Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons." Abstract excerpt: Neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD), which are mostly composed of hyperphosphorylated tau and directly correlate with dementia in AD patients. Okadaic acid (OA), a toxin extracted from marine life, can specifically inhibit protein phosphatases (PPs), including PP1 and Protein phosphatase 2A (PP2A), resulting in tau hyperphosphorylation. Humanin (HN), a pe

Source
peer_reviewed_research
DOI
10.1007/s11064-014-1410-3
PubMed
25142935
Open original source
2006Laboratory research

[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].

Content-verified record concerning Humanin: "[Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity]." Abstract excerpt: Alzheimer's disease (AD) is the leading cause of dementia for aging people, and far from control due to its obscure mechanism. Humanin, a 24-aa peptide encoded by a newly identified gene cloned from an apparently normal region of AD brain, can specifically attenuate AD-related neurotoxicity. It protects neurons from insults of various AD genes, anti-APP antibodies and Abeta by forming a homodimer

Source
peer_reviewed_research
PubMed
17262962
Open original source
2003Laboratory research

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization

Content-verified record concerning Humanin: "Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization" Abstract excerpt: The 24-residue peptide Humanin (HN), containing two Ser residues at positions 7 and 14, protects neuronal cells from insults of various Alzheimer's disease (AD) genes and A beta. It was not known why the rescue function of (S14G)HN is more potent than HN by two to three orders of magnitude. Investigating the possibility that the post-translational modification of Ser14 might play a role, we found

Source
peer_reviewed_research
DOI
10.1046/j.1471-4159.2003.01797.x
PubMed
12787071
Open original source
2004Laboratory research

N-Formylated humanin activates both formyl peptide receptor-like 1 and 2

Content-verified record concerning Humanin: "N-Formylated humanin activates both formyl peptide receptor-like 1 and 2" Abstract excerpt: We have discovered that humanin (HN) acts as a ligand for formyl peptide receptor-like 1 (FPRL1) and 2 (FPRL2). This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). In addition, we found that N-formylated HN (fHN) performed more potently as a ligand for FPRL

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2004.09.046
PubMed
15465011
Open original source
2009Laboratory research

Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis

Content-verified record concerning Humanin: "Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis" Abstract excerpt: Modulating germ cell death and survival have significant therapeutic potential for male infertility and contraception. We have shown previously that IGF binding protein 3 (IGFBP3) gene expression is up-regulated in human testis when germ cell apoptosis is induced by intratesticular hormonal deprivation created by testosterone administration. Humanin (HN) is a binding partner of IGFBP3, and both ar

Source
peer_reviewed_research
DOI
10.1210/en.2009-0577
PubMed
19952275
Open original source
2022Laboratory research

Humanin and Alzheimer's disease: The beginning of a new field.

Content-verified record concerning Humanin: "Humanin and Alzheimer's disease: The beginning of a new field." Abstract excerpt: Humanin (HN) is an endogenous peptide factor and known as a member of mitochondrial-derived peptides. We first found the gene encoding this novel 24-residue peptide in a brain of an Alzheimer's disease (AD) patient as an antagonizing factor against neuronal cell death induced by AD-associated insults. This review presents an overview of HN actions in AD-related conditions among its wide range of a

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130024
PubMed
34626746
Open original source
2003Laboratory research

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

Content-verified record concerning Humanin: "Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis" Abstract excerpt: Insulin-like growth factor-binding protein-3 (IGFBP-3) regulates IGF bioactivity and also independently modulates cell growth and survival. By using a yeast two-hybrid screen to identify IGFBP-3-interacting proteins, we cloned humanin (HN) as an IGFBP-3-binding partner. HN is a 24-aa peptide that has been shown to specifically inhibit neuronal cell death induced by familial Alzheimer's disease mut

Source
peer_reviewed_research
DOI
10.1073/pnas.2135111100
PubMed
14561895
Open original source
2020Laboratory research

Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.

Content-verified record concerning Humanin: "Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3." Abstract excerpt: It is known that the humanin (HN) peptide binding to amyloid-&#x3b2; (A&#x3b2;) protects against its cytotoxic effects, while acetylcholinesterase (AChE) binding to A&#x3b2; increases its aggregation and cytotoxicity. HN is also known to bind the insulin-like growth factor binding protein-3 (IGFBP-3). Here, we examined the regulation of A&#x3b2; conformations by HN, AChE, and IGFBP-3 both in vitro

Source
peer_reviewed_research
DOI
10.1021/acs.biochem.0c00274
PubMed
32383868
Open original source
2014Laboratory research

Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.

Content-verified record concerning Humanin: "Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes." Abstract excerpt: The prevalence of Alzheimer's disease (AD) is higher among type 2 diabetes mellitus (T2DM) patients. In T2DM patients, the progression of AD is more rapid. Furthermore, several pathophysiological pathways are common to AD and T2DM. Humanin is a recently introduced, mitochondrial-derived peptide with neuroprotective effects. Humanin can alter the mechanisms involved in AD and T2DM pathogenesis. Ins

Source
peer_reviewed_research
DOI
10.2174/1871527312666131223110147
PubMed
24365186
Open original source
2009Laboratory research

Evidence for potential functionality of nuclearly-encoded humanin isoforms.

Content-verified record concerning Humanin: "Evidence for potential functionality of nuclearly-encoded humanin isoforms." Abstract excerpt: Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. We provide bioinformatic and expression data suggesting the existence of 13 MT-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides. At least ten of these nuclear genes are expressed in human tissues, a

Source
peer_reviewed_research
DOI
10.1016/j.ygeno.2009.05.006
PubMed
19477263
Open original source
2012Laboratory research

D-Ser-containing humanin shows promotion of fibril formation.

Content-verified record concerning Humanin: "D-Ser-containing humanin shows promotion of fibril formation." Abstract excerpt: Humanin (HN), a peptide of 24 amino acid residues, suppresses the neuronal cell death that is induced by the gene products of Alzheimer's disease. HN contains two Ser residues at positions 7 and 14. Because the proportion of D-Ser isomerized from L-Ser in proteins appears to increase as cellular organs age, we explored the structural effects of the isomerization of each Ser residue in HN. By using

Source
peer_reviewed_research
DOI
10.1007/s00726-011-0971-6
PubMed
21735222
Open original source
2020Laboratory research

Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP.

Content-verified record concerning Humanin: "Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP." Abstract excerpt: Humanin (HN) is known to bind amyloid beta (A&#x3b2;)-inducing cytoprotective effects, while binding of acetylcholinesterase (AChE) to A&#x3b2; increases its aggregation and cytotoxicity. Previously, we showed that binding of HN to A&#x3b2; blocks aggregation induced by AChE and that HN decreases but does not abolish A&#x3b2;-AChE interactions in A549 cell media. Here, we set out to shed light on

Source
peer_reviewed_research
DOI
10.1002/2211-5463.13023
PubMed
33145964
Open original source
2018Laboratory research

Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.

Content-verified record concerning Humanin: "Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44." Abstract excerpt: Insulin-like growth factor-binding protein-3 (IGFBP-3) belongs to a family of IGF-binding proteins. Humanin is a peptide known to bind residues 215-232 of mature IGFBP-3 in the C-terminal region of the protein. This region of IGFBP-3 was shown earlier to bind certain glycosaminoglycans including hyaluronan (HA). Here, we characterized the binding affinities of the IGFBP-3 protein and peptide ( 215

Source
peer_reviewed_research
DOI
10.1021/acs.biochem.8b00635
PubMed
30184438
Open original source
2001Laboratory research

Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein

Content-verified record concerning Humanin: "Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein" Abstract excerpt: We report a novel gene, designated Humanin (HN) cDNA, that suppresses neuronal cell death by K595N/M596L-APP (NL-APP), a mutant causing familial Alzheimer's disease (FAD), termed Swedish mutant. Transfection of neuronal cells with HN cDNA or treatment with the coding HN polypeptide abrogated cytotoxicity by NL-APP. HN suppressed neurotoxicity by Abeta1-43 in the absence of N2 supplement, but could

Source
peer_reviewed_research
DOI
10.1006/bbrc.2001.4765
PubMed
11327724
Open original source
2018Laboratory research

Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.

Content-verified record concerning Humanin: "Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins." Abstract excerpt: Humanin (HN) is a 24-residue peptide identified from the brain of a patient with Alzheimer's disease (AD). HN has been found to protect against neuronal insult caused by A&#x3b2; peptides or transfection of familial AD mutant genes. In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their olig

Source
peer_reviewed_research
DOI
10.1038/aps.2017.169
PubMed
29265109
Open original source
2012Laboratory research

Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.

Content-verified record concerning Humanin: "Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling." Abstract excerpt: Humanin (HN) is a linear 24-aa peptide recently detected in human Alzheimer's disease (AD) brain. HN specifically inhibits neuronal cell death in vitro induced by &#xdf;-amyloid (A&#xdf;) peptides and by amyloid precursor protein and its gene mutations in familial AD, thereby representing a potential therapeutic lead structure for AD; however, its molecular mechanism of action is not well understo

Source
peer_reviewed_research
DOI
10.1002/psc.2404
PubMed
22522311
Open original source
2021Laboratory research

S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.

Content-verified record concerning Humanin: "S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1." Abstract excerpt: UV-B stimulation can induce retinopathy, whose pathogenesis is currently unclear. UV-B mediated inflammation in retinal endothelial cells is reported to be involved in the pathogenesis of retinopathy. S14G-humanin (HNG) is a neuroprotective peptide that has recently been reported to exert significant anti-inflammatory effects and protective properties against cell death. The present study aims to

Source
peer_reviewed_research
DOI
10.1007/s00011-021-01489-4
PubMed
34459932
Open original source
2018Laboratory research

Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.

Content-verified record concerning Humanin: "Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction." Abstract excerpt: Intrauterine growth restriction (IUGR) results from a lack of nutrients transferred to the developing fetus, particularly oxygen and glucose. Increased expression of the cytoprotective mitochondrial peptide, humanin (HN), and the glucose transporter 8, GLUT8, has been reported under conditions of hypoxic stress. However, the presence and cellular localization of HN and GLUT8 in IUGR-related placen

Source
peer_reviewed_research
DOI
10.1371/journal.pone.0193583
PubMed
29590129
Open original source
2013Laboratory research

Humanin binds MPP8: mapping interaction sites of the peptide and protein.

Content-verified record concerning Humanin: "Humanin binds MPP8: mapping interaction sites of the peptide and protein." Abstract excerpt: Humanin (HN), a 24-amino acid peptide encoded by the mitochondrial 16S rRNA gene, was discovered by screening a cDNA library from the occipital cortex of a patient with Alzheimer's disease (AD) for a protection factor against AD-relevant insults. Earlier, using the yeast two-hybrid system, we have identified the M-phase phosphoprotein 8 (MPP8) as a binding partner for HN. In the present work, we f

Source
peer_reviewed_research
DOI
10.1002/psc.2500
PubMed
23532874
Open original source
2021Laboratory research

Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.

Content-verified record concerning Humanin: "Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival." Abstract excerpt: Humanin (HN) is a short peptide involved in many biological processes such as apoptosis, cell survival, inflammatory response, and reaction to stressors like oxidative stress, between others. In the ovary, a correct balance between pro- and anti-apoptotic factors is crucial for folliculogenesis. In the follicular atresia, survival or death of granulosa cells is a critical process. The goal of this

Source
peer_reviewed_research
DOI
10.1530/rep-20-0197
PubMed
33764899
Open original source
2009Laboratory research

Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

Content-verified record concerning Humanin: "Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130." Abstract excerpt: Humanin (HN) inhibits neuronal death induced by various Alzheimer's disease (AD)-related insults via an unknown receptor on cell membranes. Our earlier study indicated that the activation of STAT3 was essential for HN-induced neuroprotection, suggesting that the HN receptor may belong to the cytokine receptor family. In this study, a series of loss-of-function tests indicated that gp130, the commo

Source
peer_reviewed_research
DOI
10.1091/mbc.e09-02-0168
PubMed
19386761
Open original source
2005Laboratory research

Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

Content-verified record concerning Humanin: "Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak" Abstract excerpt: Recently, we discovered that Humanin (HN), a small endogenous peptide of 24 amino acids, binds to and inhibits the proapoptotic protein Bax. We show here that HN also interacts with the BH3-only Bcl-2/Bax family protein, Bid, as well as a truncated form of Bid (tBid) associated with protease-mediated activation of this proapoptotic protein. Synthetic HN peptide binds purified Bid and tBid in vitro

Source
peer_reviewed_research
DOI
10.1074/jbc.m411902200
PubMed
15661737
Open original source
2003Laboratory research

Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes

Content-verified record concerning Humanin: "Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes" Abstract excerpt: Humanin (HN) has been reported to be an endogenous peptide that exerts highly selective neuroprotection against cell death induced by various types of Alzheimer's disease-related insults. We previously proposed the much broader cytoprotective potential of HN from the result that HN suppressed serum-deprivation-induced death of rat pheochromocytoma cells. In this study, we showed that HN also suppr

Source
peer_reviewed_research
DOI
10.1023/a:1027372519726
PubMed
14674685
Open original source
2002Laboratory research

Humanin inhibits cell death of serum-deprived PC12h cells

Content-verified record concerning Humanin: "Humanin inhibits cell death of serum-deprived PC12h cells" Abstract excerpt: Humanin (HN) and S14G HN (HNG) are recently discovered polypeptides that rescue cells from death induced by multiple different types of familial Alzheimer's disease genes and by amyloid-beta. However, the cytoprotective activity of these peptides against other cell death-inducing stimuli remains unclear. In this study, we demonstrated, using three different methods (MTS assay, caspase-3 assay, and

Source
peer_reviewed_research
DOI
10.1097/00001756-200205070-00034
PubMed
11997711
Open original source
2006Laboratory research

[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].

Content-verified record concerning Humanin: "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]." Abstract excerpt: Humanine is a human neuroprotective peptide with a wide action spectrum. To analyze molecular mechanisms of humanin functioning, a search for proteins interacting with this peptide was conducted using yeast two-hybrid system. Screening of human fetal brain cDNA library identified seven proteins with different functions that specifically interacted with humanin.

Source
peer_reviewed_research
DOI
10.1134/s1022795406020141
PubMed
16583711
Open original source
2005Laboratory research

Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase

Content-verified record concerning Humanin: "Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase" Abstract excerpt: Humanin (HN) is a newly identified neuroprotective peptide. In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells. Upon serum deprivation, expression of HN in K562 cells decreased and its intracellular distribution changed from cytoplasm to cell membrane. In HN stably transfected K562 cells, apoptosis was delayed compared with control vector transfected

Source
peer_reviewed_research
DOI
10.1007/s10495-005-1191-x
PubMed
16151632
Open original source
2004Laboratory research

Unravelling the role of Humanin.

Content-verified record concerning Humanin: "Unravelling the role of Humanin." Abstract excerpt: Humanin (HN), a recently identified neuroprotective factor against Alzheimer's disease-related insults, has been reported to function as an anti cell-death factor through multiple mechanisms. One mechanism, revealed in a glioblastoma cell line, involves the apoptosis-inducing protein Bax. This, in addition to the fact that HN is produced in certain normal tissues, such as testis, implies a potenti

Source
peer_reviewed_research
DOI
10.1016/j.molmed.2004.01.001
PubMed
15106598
Open original source
2022Insufficient evidence

Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa.

Content-verified record concerning Humanin: "Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa." Abstract excerpt: Semen cryopreservation results in deleterious effects on spermatozoa, including lipid peroxidation and a reduction in the total antioxidant components of seminal plasma. The ultimate outcome of these changes is a reduction in post-thaw semen quality. A mitochondrial derived peptide, humanin, a potent cytoprotective and antioxidant agent was used in the present study. To evaluate the efficacy of a

Source
peer_reviewed_research
DOI
10.54680/fr22110110212
PubMed
35315868
Open original source
2003Insufficient evidence

Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

Content-verified record concerning Humanin: "Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults" Abstract excerpt: Humanin (HN) is a secretory peptide that inhibits neurotoxicity by various Alzheimer's disease-relevant insults. We have so far identified that the substitution of Leu9 for Arg nullifies the extracellular secretion of HN. Here we comprehensively investigate the amino acid requirement of HN essential for its secretion and for its neuroprotective function. Intracellulary expressed HN-EGFP (EGFP N-te

Source
peer_reviewed_research
DOI
10.1016/s0196-9781(03)00106-2
PubMed
12860203
Open original source
2021Insufficient evidence

The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.

Content-verified record concerning Humanin: "The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway." Abstract excerpt: Pulpitis is reported in large populations of patients and significantly impacts their normal life quality. It is reported that the lipopolysaccharide (LPS) in Gram-negative bacteria induces severe inflammation in dental pulp tissues. S14G-humanin is a derivative of humanin and has been recently confirmed to possess promising anti-inflammatory properties. The current study aims to explore the possi

Source
peer_reviewed_research
DOI
10.1080/21655979.2021.1979914
PubMed
34605740
Open original source
2006Insufficient evidence

Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.

Content-verified record concerning Humanin: "Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1007/0-387-32824-6_11
PubMed
16700513
Open original source
2022Insufficient evidence

Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).

Content-verified record concerning Humanin: "Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG)." Abstract excerpt: Psoriasis is a chronic skin disease with 2-4% of prevalence worldwide conferring a major burden on health systems. It is assumed that the prevalence might increase due to climatic change and deterioration of protective ozone barrier. With the chances of increasing prevalence, newer and specific treatment options need to be explored. Skin is a constant target of oxidative stress owing to continuous

Source
peer_reviewed_research
DOI
10.1016/j.intimp.2022.108990
PubMed
35978518
Open original source
2003Insufficient evidence

A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults

Content-verified record concerning Humanin: "A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults" Abstract excerpt: Humanin (HN) is a newly identified neuroprotective peptide that specifically suppresses Alzheimer's disease (AD)-related neurotoxicity. HN peptide has been detected in the human AD brain as well as in mouse testis and colon by immunoblot and immunohistochemical analyses. By means of yeast two-hybrid screening, we identified TRIM11 as a novel HN-interacting protein. TRIM11, which is a member of pro

Source
peer_reviewed_research
DOI
10.1046/j.1460-9568.2003.02553.x
PubMed
12670303
Open original source
2015Insufficient evidence

Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.

Content-verified record concerning Humanin: "Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains." Abstract excerpt: Oligodendrocytes are the predominant cell type in white matter and are highly vulnerable to ischemic injury. The role of oligodendrocyte dysfunction in ischemic brain injury is unknown. In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model. Intraperitoneal HNG pre-treatment dec

Source
peer_reviewed_research
DOI
10.1002/hipo.22350
PubMed
25139533
Open original source
2013Insufficient evidence

Humanin: a harbinger of mitochondrial-derived peptides?

Content-verified record concerning Humanin: "Humanin: a harbinger of mitochondrial-derived peptides?" Abstract excerpt: Mitochondria have been largely considered as 'end-function' organelles, servicing the cell by producing energy and regulating cell death in response to complex signals. Being cellular entities with vital roles, mitochondria communicate back to the cell and actively engage in determining major cellular policies. These signals, collectively referred to as retrograde signals, are encoded in the nucle

Source
peer_reviewed_research
DOI
10.1016/j.tem.2013.01.005
PubMed
23402768
Open original source
2023Insufficient evidence

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.

Content-verified record concerning Humanin: "Humanin and Its Pathophysiological Roles in Aging: A Systematic Review." Abstract excerpt: Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. These conditions play an essential role in aging and significantly contribute to the development of age-related complications. Humanin is a mitochondrial-derived peptide (MDP), encoded by mitochondrial DNA

Source
systematic_review_or_meta_analysis
DOI
10.3390/biology12040558
PubMed
37106758
Open original source
2018Insufficient evidence

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.

Content-verified record concerning Humanin: "Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity." Abstract excerpt: Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R) injury via attenuating mitochondrial dysfunction. However, it is unclear if HNG has direct effects on mitochondrial function against o

Source
peer_reviewed_research
DOI
10.1016/j.mito.2017.08.001
PubMed
28802666
Open original source
2013Insufficient evidence

Humanin: a novel functional molecule for the green synthesis of graphene.

Content-verified record concerning Humanin: "Humanin: a novel functional molecule for the green synthesis of graphene." Abstract excerpt: The synthesis of graphene nanosheets from graphene oxide is an interesting area of nanobiotechnology because graphene-based nanomaterials have potential applications in the biomedical field. In this study, we developed a green, rapid, and simple method for the synthesis of graphene from graphene oxide, which uses the mitochondrial polypeptide humanin as a reducing agent. Graphene was prepared via

Source
peer_reviewed_research
DOI
10.1016/j.colsurfb.2013.06.018
PubMed
23850746
Open original source
2023Insufficient evidence

The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.

Content-verified record concerning Humanin: "The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study." Abstract excerpt: Does a humanin analogue (HNG) have a therapeutic effect on intrauterine adhesions (IUAs) caused by uterine cavity surgery in a rat model? HNG supplementation attenuated the development of endometrial fibrosis and IUAs, improved fertility, and contributed to the regulation of endometrial fibrosis by inhibiting endometrial ferroptosis in rats with IUAs. IUAs, which are characterized by endometrial f

Source
peer_reviewed_research
DOI
10.1093/humrep/dead196
PubMed
37814907
Open original source
2020Insufficient evidence

Humanin: A mitochondria-derived peptide with emerging properties.

Content-verified record concerning Humanin: "Humanin: A mitochondria-derived peptide with emerging properties." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1016/j.ancard.2020.07.015
PubMed
32800320
Open original source
2023Insufficient evidence

Humanin gene expression in subjects with Parkinson's disease.

Content-verified record concerning Humanin: "Humanin gene expression in subjects with Parkinson's disease." Abstract excerpt: Bradykinesia, tremor, rigidity and postural instability are the hallmark of Parkinson's disease (PD). Non-motor symptoms including cognitive, behavioral, and neuropsychiatric changes, sensory and sleep disturbances that may precede the motor symptoms by years. The peculiar pathological features of PD are decreased dopaminergic neurons and dopamine levels in the substantia nigra pars compacta and p

Source
peer_reviewed_research
DOI
10.1007/s11033-022-08132-3
PubMed
36626066
Open original source
2016Insufficient evidence

Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction.

Content-verified record concerning Humanin: "Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction." Abstract excerpt: Myocardial reperfusion via the re-canalization of occluded coronary arteries is gold standard for the treatment of acute myocardial infarction. However, reperfusion itself can cause myocardial damage due to increased reactive oxygen species (ROS) production, a process known as ischemia/reperfusion (I/R) injury. Cardiac mitochondria are the major organelle of ROS production in the heart. Cardiac mi

Source
peer_reviewed_research
DOI
10.1111/1755-5922.12210
PubMed
27434747
Open original source
2014Insufficient evidence

Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.

Content-verified record concerning Humanin: "Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1111/cns.12211
PubMed
24341938
Open original source
2006Insufficient evidence

Humanin Is a Novel Neuroprotective Agent Against Stroke

Content-verified record concerning Humanin: "Humanin Is a Novel Neuroprotective Agent Against Stroke" Abstract excerpt: Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on focal cerebral ischemia/reperfusion injury in mice. Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion. Mice were pretreated with 0.

Source
peer_reviewed_research
DOI
10.1161/01.str.0000242772.94277.1f
PubMed
16960089
Open original source
2005Insufficient evidence

Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent

Content-verified record concerning Humanin: "Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent" Abstract excerpt: Humanin (HN) was originally identified as an endogenous peptide that protects neuronal cells from apoptosis induced by various types of Alzheimer's disease-related insults. We have previously indicated that HN increases cellular ATP levels and speculated that this peptide may rescue energy-deficient cells in mitochondrial disorders. Here, we report, for the first time, increased HN expression in s

Source
peer_reviewed_research
DOI
10.1007/s00401-004-0965-5
PubMed
15759134
Open original source
2003Insufficient evidence

Humanin rescues cortical neurons from prion-peptide-induced apoptosis

Content-verified record concerning Humanin: "Humanin rescues cortical neurons from prion-peptide-induced apoptosis" Abstract excerpt: We recently demonstrated that a soluble oligomeric prion peptide, the putative 118-135 transmembrane domain of prion protein (PrP), exhibited membrane fusogenic properties and induced apoptotic cell death both in vitro and in vivo. A recently discovered rescue factor humanin (HN) was shown to protect neuronal cells from various insults involved in human neurodegenerative diseases. We thus addresse

Source
peer_reviewed_research
DOI
10.1016/j.mcn.2003.09.017
PubMed
14962743
Open original source
2003Insufficient evidence

Humanin peptide suppresses apoptosis by interfering with Bax activation

Content-verified record concerning Humanin: "Humanin peptide suppresses apoptosis by interfering with Bax activation" Abstract excerpt: Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. Bax resides in an inactive state in the cytosol of many cells. In response to death stimuli, Bax protein undergoes conformational changes that expose membrane-targeting domains, resulting in its translocation to mitochondrial membranes, where Bax inser

Source
peer_reviewed_research
DOI
10.1038/nature01627
PubMed
12732850
Open original source
2015Insufficient evidence

Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.

Content-verified record concerning Humanin: "Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities." Abstract excerpt: Humanin is a 24-amino acid, secreted bioactive peptide that prevents various types of cell death and improves some types of cell dysfunction. Humanin inhibits neuronal cell death that is caused by a familial Alzheimer's disease (AD)-linked gene via binding to the heterotrimeric Humanin receptor (htHNR). This suggests that Humanin may play a protective role in AD-related pathogenesis. Calmodulin-li

Source
systematic_review_or_meta_analysis
DOI
10.1007/s12035-014-8799-1
PubMed
24969584
Open original source
2010Insufficient evidence

Immunolocalization of humanin in human sperm and testis.

Content-verified record concerning Humanin: "Immunolocalization of humanin in human sperm and testis." Abstract excerpt: We have discovered, by immunocytochemistry and immunoelectronmicroscopy, that humanin (HN) is expressed in human ejaculated sperm and testis. In sperm, the HN immunolabeling pattern depends on sperm morphology; in particular, HN is mainly localized in the midpiece of sperm in semen samples with normal morphology and in cytoplasmic residues and entire tail in those with abnormal morphology. We also

Source
peer_reviewed_research
DOI
10.1016/j.fertnstert.2010.04.075
PubMed
20542501
Open original source
Insufficient evidence

Diagnostic Value of Serum Humanin-Like 3 Levels in Multiple Sclerosis Patients with Predominant Optic Nerve and Spinal Cord Involvement: A Preliminary Study.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.29399/npa.29115
PubMed
41777515
Open original source
2017Insufficient evidence

Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.

Content-verified record concerning Humanin: "Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells." Abstract excerpt: Foam cell formation, which is caused by imbalanced cholesterol influx and efflux by macrophages, plays a vital role in the occurrence and development of atherosclerosis. Humanin (HN), a mitochondria-derived peptide, can prevent the production of reactive oxygen species and death of human aortic endothelial cells exposed to oxidized low-density lipoprotein (ox-LDL) and has a protective effect on pa

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2016.10.138
PubMed
27815075
Open original source
2005Insufficient evidence

Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

Content-verified record concerning Humanin: "Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL" Abstract excerpt: Humanin (HN) is a recently identified endogenous peptide that protects cells against cytotoxicity induced by various stimuli. Recently, we showed that HN binds to and inhibits Bax, a proapoptotic Bcl-2 family protein, suggesting a mechanism for HN action. In this study, we identified Bim, a Bcl-2 homology 3-only member of the Bcl-2/Bax family, as an additional HN target protein. Using in vitro pro

Source
peer_reviewed_research
DOI
10.1074/jbc.m413062200
PubMed
15661735
Open original source
Insufficient evidence

Mitochondrial stress and mitokines in aging.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1111/acel.13770
PubMed
36642986
Open original source
Insufficient evidence

Mitochondrial-Derived Peptides Exacerbate Senescence.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1089/rej.2018.2114
PubMed
30058454
Open original source
Insufficient evidence

Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3390/biomedicines14051048
PubMed
42193373
Open original source
Insufficient evidence

Characterization of the Effects of a Humanin Fragment Peptide (HNF&lt;sub&gt;14&lt;/sub&gt;) in Age-Related Macular Degeneration.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3390/jcm15051686
PubMed
41827105
Open original source
2005Insufficient evidence

Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.

Content-verified record concerning Humanin: "Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality." Abstract excerpt: To define the pathogenesis of pigmented villonodular synovitis (PVNS), by searching for highly expressed genes in primary synovial cells from patients with PVNS. A combination of subtraction cloning and Southern colony hybridisation was used to detect highly expressed genes in PVNS in comparison with rheumatoid synovial cells. Northern hybridisation was performed to confirm the differential expres

Source
peer_reviewed_research
DOI
10.1136/ard.2004.025445
PubMed
15567815
Open original source
2015Insufficient evidence

The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

Content-verified record concerning Humanin: "The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice." Abstract excerpt: Humanin is a peptide that is cytoprotective against stresses in many cell types. We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells. Young adult male mice were inoculated iv with murine melanoma cells. After 1 week, cancer-bearing mice we

Source
peer_reviewed_research
DOI
10.1210/en.2015-1542
PubMed
26384090
Open original source
2022Insufficient evidence

Structural basis of FPR2 in recognition of Aβ<sub>42</sub> and neuroprotection by humanin.

Content-verified record concerning Humanin: "Structural basis of FPR2 in recognition of Aβ<sub>42</sub> and neuroprotection by humanin." Abstract excerpt: Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the &#x3b2; amyloid peptide A&#x3b2; 42 and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by A&#x3b2; 42 , implying its involvement in the pathogenesis of Alzheimer's disease (AD). However, the interaction pattern between FPR2 and A&#x3b2; 42 or humanin remains unknown. Here w

Source
peer_reviewed_research
DOI
10.1038/s41467-022-29361-x
PubMed
35365641
Open original source
2017Insufficient evidence

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.

Content-verified record concerning Humanin: "Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage." Abstract excerpt: Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation, being available for wet AMD, to date there are no FDA-approved therapies for dry AMD. Substantial evidence implicates mitochondrial damage and retinal

Source
peer_reviewed_research
DOI
10.1038/cddis.2017.348
PubMed
28726777
Open original source
Insufficient evidence

Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1038/s41598-026-62834-3
PubMed
42471450
Open original source
Insufficient evidence

Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3390/biology15131060
PubMed
42450608
Open original source
Insufficient evidence

Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1186/s13195-023-01303-9
PubMed
37730689
Open original source
2021Insufficient evidence

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.

Content-verified record concerning Humanin: "Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging." Abstract excerpt: Fibroblast Growth Factor 21 (FGF21), Growth Differentiation Factor 15 (GDF15), and Humanin (HN) are mitochondrial stress-related mitokines, whose role in health and disease is still debated. In this study, we confirmed that their plasma levels are positively correlated with age in healthy subjects. However, when looking at patients with type 2 diabetes (T2D) or Alzheimer's disease (AD), two age-re

Source
peer_reviewed_research
DOI
10.1007/s11357-020-00287-w
PubMed
33131010
Open original source
2026Insufficient evidence

[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].

Content-verified record concerning Humanin: "[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure]." Abstract excerpt: Objective: To evaluate the effects of a standardized rehabilitation protocol on physical performance, exercise tolerance, and prognosis in hospitalized patients with acute exacerbation of chronic heart failure (CHF), and to explore the clinical value of the serum Humanin (a mitochondria-derived peptide) to C-reactive protein (CRP) ratio in prognostic risk stratification. Methods: This non-randomiz

Source
peer_reviewed_research
DOI
10.3760/cma.j.cn112148-20260515-00320
PubMed
42736132
Open original source
Insufficient evidence

Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.21203/rs.3.rs-9572557/v1
Open original source
Insufficient evidence

Renoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.21203/rs.3.rs-9040130/v1
Open original source
Insufficient evidence

Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1177/07482337261445494
PubMed
42041115
Open original source
Insufficient evidence

Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.64898/2026.03.20.713049
Open original source
Insufficient evidence

Humanin analogue promotes metabolic reprogramming to protect the ischemic heart

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.64898/2026.06.16.732776
Open original source
2011Insufficient evidence

Advances in characterization of neuroprotective peptide, humanin.

Content-verified record concerning Humanin: "Advances in characterization of neuroprotective peptide, humanin." Abstract excerpt: Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid &#x3b2;-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have been suggested in some cases. However, the way HN binds to the target molecules has never been clarified. Here we will review the structures of HN

Source
systematic_review_or_meta_analysis
DOI
10.2174/092986711798347261
PubMed
22172065
Open original source
2008Insufficient evidence

Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway

Content-verified record concerning Humanin: "Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway" Abstract excerpt: Humanin (HN) is an anti-apoptotic peptide that suppresses neuronal cell death induced by Alzheimer's disease, prion protein fragments, and serum deprivation. Recently, we demonstrated that Gly14-HN (HNG), a variant of HN in which the 14th amino acid serine is replaced with glycine, can decrease apoptotic neuronal death and reduce infarct volume in a focal cerebral ischemia/reperfusion mouse model.

Source
peer_reviewed_research
DOI
10.1016/j.brainres.2008.06.018
PubMed
18590709
Open original source
2005Insufficient evidence

Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA

Content-verified record concerning Humanin: "Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA" Abstract excerpt: Humanin (HN) was originally identified as an endogenous peptide that protects neuronal cells from apoptosis by mutant Alzheimer's disease genes. This 24-residue peptide has been recently shown to suppress apoptosis by interfering with activation of Bcl-2-associated X protein (Bax) in cytosol. In the present study, we showed that HN increases ATP levels in human lymphocytes, muscular TE671 cells, a

Source
peer_reviewed_research
DOI
10.1016/j.npep.2004.11.004
PubMed
15752543
Open original source
2026Insufficient evidence

Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.

Content-verified record concerning Humanin: "Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats." Abstract excerpt: Selective serotonin reuptake inhibitors (SSRIs) such as paroxetine frequently induce male sexual dysfunction by disrupting neuroendocrine balance and central dopaminergic pathways. This study investigated whether humanin, a mitochondria-derived peptide, could mitigate paroxetine-induced reproductive and behavioral impairments in male Sprague-Dawley rats. In Phase 1, fifty rats were randomized into

Source
peer_reviewed_research
DOI
10.1016/j.repbio.2026.101254
PubMed
42480246
Open original source
2016Insufficient evidence

Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.

Content-verified record concerning Humanin: "Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism." Abstract excerpt: Humanin (HN) is a mitochondrially encoded and secreted peptide linked to glucose metabolism and tissue protecting mechanisms. Whether skeletal muscle HN gene or protein expression is influenced by exercise remains unknown. In this intervention study we show, for the first time, that HN protein levels increase in human skeletal muscle following 12&#xa0;weeks of resistance training in persons with p

Source
peer_reviewed_research
DOI
10.14814/phy2.13063
PubMed
27923980
Open original source
Insufficient evidence

Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.31083/ap54760
PubMed
42694894
Open original source
Insufficient evidence

Diagnostic potential of serum humanin in breast cancer among the Egyptian population.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1007/s12672-025-04325-x
PubMed
41518474
Open original source
2019Insufficient evidence

Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.

Content-verified record concerning Humanin: "Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions." Abstract excerpt: Amyloid fibrils in Alzheimer's disease are composed of amyloid-&#x3b2; (A&#x3b2;) peptides of variant lengths. Humanin (HN), a 24 amino acid residue neuroprotective peptide, is known to interact with the predominant A&#x3b2; isoform in the brain, A&#x3b2; (1-40). Here, we constructed smaller segments of A&#x3b2; and HN and identified residues in HN important for both HN-HN and HN-A&#x3b2; interact

Source
peer_reviewed_research
DOI
10.2174/0929866526666190405122117
PubMed
30950343
Open original source
Insufficient evidence

Mitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1093/ajrcmb/aanag116
PubMed
42262906
Open original source
2009Insufficient evidence

Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.

Content-verified record concerning Humanin: "Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin." Abstract excerpt: Humanin (HN) inhibits Alzheimer's disease (AD)-relevant neuronal death and dysfunction, by interacting with a receptor (s) involving ciliary neurotrophic factor receptor alpha (CNTFR), WSX-1, and gp130. It remains unknown whether this complex is the sole HN receptor that mediates HN-induced anti-AD activity. We here report that an alternatively spliced WSX-1 isoform, encoding an extracellular 270-

Source
peer_reviewed_research
DOI
10.1016/j.bbrc.2009.08.095
PubMed
19703422
Open original source
2013Insufficient evidence

SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.

Content-verified record concerning Humanin: "SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase." Abstract excerpt: Humanin is a secreted bioactive peptide that suppresses cell toxicity caused by a variety of insults. The neuroprotective effect of Humanin against Alzheimer disease (AD)-related death is mediated by the binding of Humanin to its heterotrimeric Humanin receptor composed of ciliary neurotrophic receptor &#x3b1;, WSX-1, and gp130, as well as the activation of intracellular signaling pathways includi

Source
peer_reviewed_research
DOI
10.1074/jbc.m113.469692
PubMed
23861391
Open original source
2023Insufficient evidence

A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.

Content-verified record concerning Humanin: "A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin." Abstract excerpt: Purpose: This study investigated the Humanin levels in the umbilical cord blood of fetuses with late fetal growth restriction (FGR) and -evaluated their association with perinatal outcomes. Materials and Methods: A total of 95 single pregnancies between 32-41 wk (45 with late FGR and 50 controls) were included. Doppler parameters, birth weight and the need for neonatal intensive care unit admissio

Source
peer_reviewed_research
DOI
10.1080/15513815.2023.2229432
PubMed
37366369
Open original source
2022Insufficient evidence

Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Content-verified record concerning Humanin: "Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans." Abstract excerpt: Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE). A total of 327 subjects were recrui

Source
peer_reviewed_research
DOI
10.1016/j.bbagen.2021.130010
PubMed
34525397
Open original source
Insufficient evidence

Mitochondrial-derived peptides in energy metabolism.

Source reference associated with Humanin. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1152/ajpendo.00249.2020
PubMed
32776825
Open original source
2004Insufficient evidence

High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.

Content-verified record concerning Humanin: "High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence." Abstract excerpt: Humanin is a novel, 24-mer residue bioactive peptide, which antagonizes Alzheimer's disease (AD) related neurotoxicity and offers a hope for developing new therapeutics against AD. Access to adequate amounts of pure humanin is a prerequisite for further, thorough, investigation of the pharmacological properties and therapeutic potency of the peptide. Until now, humanin has been obtained mainly by

Source
peer_reviewed_research
DOI
10.1002/psc.572
PubMed
15526712
Open original source
2019Insufficient evidence

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

Content-verified record concerning Humanin: "A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome." Abstract excerpt: Q fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiology. In this study, we aimed to identify transcriptome profiles that could aid to better understand the pathophysiology of QFS. RNA of monocytes was collected from QFS patients (n = 10), chron

Source
peer_reviewed_research
DOI
10.1186/s12967-019-1906-3
PubMed
31088495
Open original source
2005Insufficient evidence

Construction of a eukaryotic expression plasmid of Humanin.

Content-verified record concerning Humanin: "Construction of a eukaryotic expression plasmid of Humanin." Abstract excerpt: To construct a eukaryotic expression plasmid pcDNA3.1(-)-Humanin. The recombinant plasmid pGEMEX-1-Humanin was digested with restriction endonucleases BamH I and Hind III and the Humanin gene fragments, about 100 bp length, were obtained. Then the Humanin gene fragments were inserted into eukaryotic expression vector pcDNA3.1(-) and the recombinant plasmids pcDNA3.1(-)-Humanin were identified by s

Source
peer_reviewed_research
DOI
10.1631/jzus.2005.b0011
PubMed
15593385
Open original source
2014Insufficient evidence

Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.

Content-verified record concerning Humanin: "Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment." Abstract excerpt: Bortezomib is a proteasome inhibitor currently studied in clinical trials of childhood cancers. So far, no side effects on bone growth have been reported in treated children. However, bortezomib was recently found to induce apoptosis in growth plate chondrocytes and impair linear bone growth in treated mice. We hypothesize that [Gly(14)]-humanin (HNG), a 24-amino acid synthetic antiapoptotic pepti

Source
peer_reviewed_research
DOI
10.1093/jnci/djt459
PubMed
24586107
Open original source
2014Insufficient evidence

New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.

Content-verified record concerning Humanin: "New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects." (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1093/jnci/dju006
PubMed
24586106
Open original source
2021Insufficient evidence

Humanin: A Potential Treatment for PCOS?

Content-verified record concerning Humanin: "Humanin: A Potential Treatment for PCOS?" (identity confirmed; no abstract text available to excerpt.)

Source
peer_reviewed_research
DOI
10.1210/endocr/bqab085
PubMed
33899108
Open original source

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

Open chemistry and biological context ↓
Chemical identity

Molecular and structural record

Structured record
Molecular formula
C119H204N34O32S2
Molecular weight (Da)
2687.2
SMILES
CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(CCSC)N
InChI
InChI=1S/C119H204N34O32S2/c1-19-65(14)92(112(180)144-81(54-90(160)161)104(172)145-82(52-63(10)11)115(183)153-46-29-37-87(153)110(178)149-91(64(12)13)111(179)139-72(32-23-24-41-120)97(165)136-74(35-27-44-130-119(126)127)98(166)135-73(34-26-43-129-118(124)125)96(164)133-67(16)116(184)185)150-99(167)75(38-39-89(158)159)137-106(174)84(57-155)147-113(181)93(68(17)156)151-105(173)79(51-62(8)9)142-101(169)77(49-60(4)5)140-100(168)76(48-59(2)3)141-102(170)78(50-61(6)7)143-108(176)85(58-186)148-107(175)83(56-154)146-103(171)80(53-69-30-21-20-22-31-69)134-88(157)55-131-95(163)71(33-25-42-128-117(122)123)138-109(177)86-36-28-45-152(86)114(182)66(15)132-94(162)70(121)40-47-187-18/h20-22,30-31,59-68,70-87,91-93,154-156,186H,19,23-29,32-58,120-121H2,1-18H3,(H,131,163)(H,132,162)(H,133,164)(H,134,157)(H,135,166)(H,136,165)(H,137,174)(H,138,177)(H,139,179)(H,140,168)(H,141,170)(H,142,169)(H,143,176)(H,144,180)(H,145,172)(H,146,171)(H,147,181)(H,148,175)(H,149,178)(H,150,167)(H,151,173)(H,158,159)(H,160,161)(H,184,185)(H4,122,123,128)(H4,124,125,129)(H4,126,127,130)/t65-,66-,67-,68+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,91-,92-,93-/m0/s1
InChIKey
DPEUWKZJZIPZKE-OFANTOPUSA-N

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

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Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.

Research chronology

  1. 2001 · study · Temporal status not established

    Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

    peer_reviewed_research

  2. 2001 · study · Temporal status not established

    [Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.

    peer_reviewed_research

  3. 2001 · study · Temporal status not established

    Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein

    peer_reviewed_research

  4. 2002 · study · Temporal status not established

    A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.

    peer_reviewed_research

  5. 2002 · study · Temporal status not established

    Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

    peer_reviewed_research

  6. 2002 · study · Temporal status not established

    Humanin inhibits cell death of serum-deprived PC12h cells

    peer_reviewed_research

  7. 2003 · study · Temporal status not established

    Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40

    peer_reviewed_research

  8. 2003 · study · Temporal status not established

    Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity

    peer_reviewed_research

  9. 2003 · study · Temporal status not established

    Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization

    peer_reviewed_research

  10. 2003 · study · Temporal status not established

    Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

    peer_reviewed_research

  11. 2003 · study · Temporal status not established

    Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes

    peer_reviewed_research

  12. 2003 · study · Temporal status not established

    Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

    peer_reviewed_research

  13. 2003 · study · Temporal status not established

    A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults

    peer_reviewed_research

  14. 2003 · study · Temporal status not established

    Humanin rescues cortical neurons from prion-peptide-induced apoptosis

    peer_reviewed_research

  15. 2003 · study · Temporal status not established

    Humanin peptide suppresses apoptosis by interfering with Bax activation

    peer_reviewed_research

  16. 2004 · study · Temporal status not established

    Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.

    peer_reviewed_research

  17. 2004 · study · Temporal status not established

    Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.

    peer_reviewed_research

  18. 2004 · study · Temporal status not established

    Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.

    peer_reviewed_research

  19. 2004 · study · Temporal status not established

    Humanin: After the Discovery

    peer_reviewed_research

  20. 2004 · study · Temporal status not established

    Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

    peer_reviewed_research

  21. 2004 · study · Temporal status not established

    N-Formylated humanin activates both formyl peptide receptor-like 1 and 2

    peer_reviewed_research

  22. 2004 · study · Temporal status not established

    Unravelling the role of Humanin.

    peer_reviewed_research

  23. 2004 · study · Temporal status not established

    High-yield, solid-phase synthesis of humanin, an Alzheimer's disease associated, novel 24-mer peptide which contains a difficult sequence.

    peer_reviewed_research

  24. 2005 · study · Temporal status not established

    Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.

    peer_reviewed_research

  25. 2005 · study · Temporal status not established

    Development of a Femtomolar-Acting Humanin Derivative Named Colivelin by Attaching Activity-Dependent Neurotrophic Factor to Its N Terminus: Characterization of Colivelin-Mediated Neuroprotection against Alzheimer's Disease-Relevant InsultsIn VitroandIn Vivo

    peer_reviewed_research

  26. 2005 · study · Temporal status not established

    Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

    peer_reviewed_research

  27. 2005 · study · Temporal status not established

    Humanin Attenuates Apoptosis Induced by DRPLA Proteins With Expanded Polyglutamine Stretches

    peer_reviewed_research

  28. 2005 · study · Temporal status not established

    A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice

    peer_reviewed_research

  29. 2005 · study · Temporal status not established

    Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

    peer_reviewed_research

  30. 2005 · study · Temporal status not established

    Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase

    peer_reviewed_research

  31. 2005 · study · Temporal status not established

    Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent

    peer_reviewed_research

  32. 2005 · study · Temporal status not established

    Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

    peer_reviewed_research

  33. 2005 · study · Temporal status not established

    Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.

    peer_reviewed_research

  34. 2005 · study · Temporal status not established

    Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA

    peer_reviewed_research

  35. 2005 · study · Temporal status not established

    Construction of a eukaryotic expression plasmid of Humanin.

    peer_reviewed_research

  36. 2006 · study · Temporal status not established

    Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.

    peer_reviewed_research

  37. 2006 · study · Temporal status not established

    Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.

    peer_reviewed_research

  38. 2006 · study · Temporal status not established

    Zinc(II) binds to the neuroprotective peptide humanin.

    peer_reviewed_research

  39. 2006 · study · Temporal status not established

    The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.

    peer_reviewed_research

  40. 2006 · study · Temporal status not established

    Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia

    peer_reviewed_research

  41. 2006 · study · Temporal status not established

    Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.

    peer_reviewed_research

  42. 2006 · study · Temporal status not established

    [Recent progress in neuroprotection of humanin against Alzheimer's disease-relevant neurotoxicity].

    peer_reviewed_research

  43. 2006 · study · Temporal status not established

    [Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system].

    peer_reviewed_research

  44. 2006 · study · Temporal status not established

    Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.

    peer_reviewed_research

  45. 2006 · study · Temporal status not established

    Humanin Is a Novel Neuroprotective Agent Against Stroke

    peer_reviewed_research

  46. 2007 · study · Temporal status not established

    Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.

    peer_reviewed_research

  47. 2007 · study · Temporal status not established

    Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.

    peer_reviewed_research

  48. 2008 · study · Temporal status not established

    Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation.

    peer_reviewed_research

  49. 2008 · study · Temporal status not established

    The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol.

    peer_reviewed_research

  50. 2008 · study · Temporal status not established

    The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues

    peer_reviewed_research

  51. 2008 · study · Temporal status not established

    Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.

    peer_reviewed_research

  52. 2008 · study · Temporal status not established

    Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway

    peer_reviewed_research

  53. 2009 · study · Temporal status not established

    In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.

    peer_reviewed_research

  54. 2009 · study · Temporal status not established

    Humanin structural versatility and interaction with model cerebral cortex membranes.

    peer_reviewed_research

  55. 2009 · study · Temporal status not established

    Humanin: a novel central regulator of peripheral insulin action.

    peer_reviewed_research

  56. 2009 · study · Temporal status not established

    Humanin; a defender against Alzheimer's disease?

    peer_reviewed_research

  57. 2009 · study · Temporal status not established

    Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis

    peer_reviewed_research

  58. 2009 · study · Temporal status not established

    Evidence for potential functionality of nuclearly-encoded humanin isoforms.

    peer_reviewed_research

  59. 2009 · study · Temporal status not established

    Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

    peer_reviewed_research

  60. 2009 · study · Temporal status not established

    Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin.

    peer_reviewed_research

  61. 2010 · study · Temporal status not established

    The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice.

    peer_reviewed_research

  62. 2010 · study · Temporal status not established

    Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.

    peer_reviewed_research

  63. 2010 · study · Temporal status not established

    Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.

    peer_reviewed_research

  64. 2010 · study · Temporal status not established

    Structure changes of natively disordered Humanin in the presence of lipid.

    peer_reviewed_research

  65. 2010 · study · Temporal status not established

    Humanin and the receptors for humanin.

    peer_reviewed_research

  66. 2010 · study · Temporal status not established

    [Gly(14)]-humanin rescues long-term potentiation from amyloid beta protein-induced impairment in the rat hippocampal CA1 region in vivo.

    peer_reviewed_research

  67. 2010 · study · Temporal status not established

    Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.

    peer_reviewed_research

  68. 2010 · study · Temporal status not established

    Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

    peer_reviewed_research

  69. 2010 · study · Temporal status not established

    Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.

    peer_reviewed_research

  70. 2010 · study · Temporal status not established

    Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.

    peer_reviewed_research

  71. 2010 · study · Temporal status not established

    [Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].

    peer_reviewed_research

  72. 2010 · study · Temporal status not established

    Immunolocalization of humanin in human sperm and testis.

    peer_reviewed_research

  73. 2011 · study · Temporal status not established

    The biological activity of Humanin analogs correlates with structure stabilities in solution.

    peer_reviewed_research

  74. 2011 · study · Temporal status not established

    VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.

    peer_reviewed_research

  75. 2011 · study · Temporal status not established

    Humanin signal for Alzheimer's disease.

    peer_reviewed_research

  76. 2011 · study · Temporal status not established

    [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].

    peer_reviewed_research

  77. 2011 · study · Temporal status not established

    Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice.

    peer_reviewed_research

  78. 2011 · study · Temporal status not established

    A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.

    peer_reviewed_research

  79. 2011 · study · Temporal status not established

    Structure of three Humanin peptides with different activities upon interaction with liposome.

    peer_reviewed_research

  80. 2011 · study · Temporal status not established

    Advances in characterization of neuroprotective peptide, humanin.

    systematic_review_or_meta_analysis

  81. 2012 · study · Temporal status not established

    S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.

    peer_reviewed_research

  82. 2012 · study · Temporal status not established

    Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.

    peer_reviewed_research

  83. 2012 · study · Temporal status not established

    Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.

    peer_reviewed_research

  84. 2012 · study · Temporal status not established

    Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans.

    peer_reviewed_research

  85. 2012 · study · Temporal status not established

    [[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].

    peer_reviewed_research

  86. 2012 · study · Temporal status not established

    D-Ser-containing humanin shows promotion of fibril formation.

    peer_reviewed_research

  87. 2012 · study · Temporal status not established

    Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling.

    peer_reviewed_research

  88. 2013 · study · Temporal status not established

    Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.

    peer_reviewed_research

  89. 2013 · study · Temporal status not established

    The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis.

    peer_reviewed_research

  90. 2013 · study · Temporal status not established

    Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.

    peer_reviewed_research

  91. 2013 · study · Temporal status not established

    The emerging role of the mitochondrial-derived peptide humanin in stress resistance.

    peer_reviewed_research

  92. 2013 · study · Temporal status not established

    Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.

    peer_reviewed_research

  93. 2013 · study · Temporal status not established

    Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.

    peer_reviewed_research

  94. 2013 · study · Temporal status not established

    S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.

    peer_reviewed_research

  95. 2013 · study · Temporal status not established

    [Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage.

    peer_reviewed_research

  96. 2013 · study · Temporal status not established

    A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.

    peer_reviewed_research

  97. 2013 · study · Temporal status not established

    Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.

    peer_reviewed_research

  98. 2013 · study · Temporal status not established

    [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.

    peer_reviewed_research

  99. 2013 · study · Temporal status not established

    Circulating humanin levels are associated with preserved coronary endothelial function.

    peer_reviewed_research

  100. 2013 · study · Temporal status not established

    Humanin binds MPP8: mapping interaction sites of the peptide and protein.

    peer_reviewed_research

  101. 2013 · study · Temporal status not established

    Humanin: a harbinger of mitochondrial-derived peptides?

    peer_reviewed_research

  102. 2013 · study · Temporal status not established

    Humanin: a novel functional molecule for the green synthesis of graphene.

    peer_reviewed_research

  103. 2013 · study · Temporal status not established

    SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.

    peer_reviewed_research

  104. 2014 · study · Temporal status not established

    Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells.

    peer_reviewed_research

  105. 2014 · study · Temporal status not established

    IGF-I regulates the age-dependent signaling peptide humanin.

    peer_reviewed_research

  106. 2014 · study · Temporal status not established

    Apollon/Bruce is upregulated by Humanin.

    peer_reviewed_research

  107. 2014 · study · Temporal status not established

    Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity not by NMDA receptor.

    peer_reviewed_research

  108. 2014 · study · Temporal status not established

    Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.

    peer_reviewed_research

  109. 2014 · study · Temporal status not established

    Inactive C8A‑humanin analog is as stable as a potent S14G‑humanin analog.

    peer_reviewed_research

  110. 2014 · study · Temporal status not established

    Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.

    peer_reviewed_research

  111. 2014 · study · Temporal status not established

    Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.

    peer_reviewed_research

  112. 2014 · study · Temporal status not established

    Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.

    peer_reviewed_research

  113. 2014 · study · Temporal status not established

    Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.

    peer_reviewed_research

  114. 2014 · study · Temporal status not established

    Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.

    peer_reviewed_research

  115. 2014 · study · Temporal status not established

    New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.

    peer_reviewed_research

  116. 2015 · study · Temporal status not established

    Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.

    peer_reviewed_research

  117. 2015 · study · Temporal status not established

    Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.

    peer_reviewed_research

  118. 2015 · study · Temporal status not established

    Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.

    peer_reviewed_research

  119. 2015 · study · Temporal status not established

    Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.

    peer_reviewed_research

  120. 2015 · study · Temporal status not established

    Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production.

    peer_reviewed_research

  121. 2015 · study · Temporal status not established

    The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.

    peer_reviewed_research

  122. 2015 · study · Temporal status not established

    Central effects of humanin on hepatic triglyceride secretion.

    peer_reviewed_research

  123. 2015 · study · Temporal status not established

    The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.

    peer_reviewed_research

  124. 2015 · study · Temporal status not established

    Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.

    peer_reviewed_research

  125. 2015 · study · Temporal status not established

    Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.

    systematic_review_or_meta_analysis

  126. 2015 · study · Temporal status not established

    The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

    peer_reviewed_research

  127. 2016 · study · Temporal status not established

    The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

    peer_reviewed_research

  128. 2016 · study · Temporal status not established

    The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.

    peer_reviewed_research

  129. 2016 · study · Temporal status not established

    Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.

    peer_reviewed_research

  130. 2016 · study · Temporal status not established

    Humanin: Functional Interfaces with IGF-I.

    peer_reviewed_research

  131. 2016 · study · Temporal status not established

    Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.

    peer_reviewed_research

  132. 2016 · study · Temporal status not established

    Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.

    peer_reviewed_research

  133. 2016 · study · Temporal status not established

    [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.

    peer_reviewed_research

  134. 2016 · study · Temporal status not established

    Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.

    peer_reviewed_research

  135. 2016 · study · Temporal status not established

    Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.

    peer_reviewed_research

  136. 2016 · study · Temporal status not established

    Potential Roles of Humanin on Apoptosis in the Heart.

    peer_reviewed_research

  137. 2016 · study · Temporal status not established

    Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction.

    peer_reviewed_research

  138. 2016 · study · Temporal status not established

    Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.

    peer_reviewed_research

  139. 2017 · study · Temporal status not established

    Pseudogenization of the <i>Humanin</i> gene is common in the mitochondrial DNA of many vertebrates.

    peer_reviewed_research

  140. 2017 · study · Temporal status not established

    Neuroprotective effect of G<sup>14</sup>-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 - STAT3 - MCL-1 signal transduction pathway in rats.

    peer_reviewed_research

  141. 2017 · study · Temporal status not established

    Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.

    peer_reviewed_research

  142. 2017 · study · Temporal status not established

    Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.

    peer_reviewed_research

  143. 2017 · study · Temporal status not established

    Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.

    peer_reviewed_research

  144. 2017 · study · Temporal status not established

    High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia/reperfusion injury by reducing mitochondrial dysfunction.

    peer_reviewed_research

  145. 2017 · study · Temporal status not established

    Humanin ameliorates diazepam-induced memory deficit in mice.

    peer_reviewed_research

  146. 2017 · study · Temporal status not established

    Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.

    peer_reviewed_research

  147. 2017 · study · Temporal status not established

    Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.

    peer_reviewed_research

  148. 2017 · study · Temporal status not established

    Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.

    peer_reviewed_research

  149. 2017 · study · Temporal status not established

    Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.

    peer_reviewed_research

  150. 2017 · study · Temporal status not established

    Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.

    peer_reviewed_research

  151. 2017 · study · Temporal status not established

    Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.

    peer_reviewed_research

  152. 2018 · study · Temporal status not established

    Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

    peer_reviewed_research

  153. 2018 · study · Temporal status not established

    [The level of circulating humanin in patients with ischemic heart disease.]

    peer_reviewed_research

  154. 2018 · study · Temporal status not established

    A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.

    peer_reviewed_research

  155. 2018 · study · Temporal status not established

    Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.

    peer_reviewed_research

  156. 2018 · study · Temporal status not established

    Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus.

    peer_reviewed_research

  157. 2018 · study · Temporal status not established

    The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.

    peer_reviewed_research

  158. 2018 · study · Temporal status not established

    Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.

    peer_reviewed_research

  159. 2018 · study · Temporal status not established

    Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.

    peer_reviewed_research

  160. 2018 · study · Temporal status not established

    Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury.

    peer_reviewed_research

  161. 2018 · study · Temporal status not established

    Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.

    peer_reviewed_research

  162. 2018 · study · Temporal status not established

    Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2.

    peer_reviewed_research

  163. 2018 · study · Temporal status not established

    Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.

    peer_reviewed_research

  164. 2018 · study · Temporal status not established

    Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies.

    peer_reviewed_research

  165. 2018 · study · Temporal status not established

    Humanin is an endogenous activator of chaperone-mediated autophagy.

    peer_reviewed_research

  166. 2018 · study · Temporal status not established

    Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway.

    peer_reviewed_research

  167. 2018 · study · Temporal status not established

    S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.

    peer_reviewed_research

  168. 2018 · study · Temporal status not established

    Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP.

    peer_reviewed_research

  169. 2018 · study · Temporal status not established

    Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.

    peer_reviewed_research

  170. 2018 · study · Temporal status not established

    Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.

    peer_reviewed_research

  171. 2018 · study · Temporal status not established

    Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.

    peer_reviewed_research

  172. 2018 · study · Temporal status not established

    Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity.

    peer_reviewed_research

  173. 2019 · study · Temporal status not established

    The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.

    peer_reviewed_research

  174. 2019 · study · Temporal status not established

    Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.

    peer_reviewed_research

  175. 2019 · study · Temporal status not established

    Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.

    peer_reviewed_research

  176. 2019 · study · Temporal status not established

    Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

    peer_reviewed_research

  177. 2019 · study · Temporal status not established

    Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.

    peer_reviewed_research

  178. 2019 · study · Temporal status not established

    Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.

    peer_reviewed_research

  179. 2019 · study · Temporal status not established

    Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.

    peer_reviewed_research

  180. 2019 · study · Temporal status not established

    Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.

    peer_reviewed_research

  181. 2019 · study · Temporal status not established

    Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

    peer_reviewed_research

  182. 2019 · study · Temporal status not established

    The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.

    peer_reviewed_research

  183. 2019 · study · Temporal status not established

    Potent humanin analogue (HNG) protects human sperm from freeze-thaw-induced damage.

    peer_reviewed_research

  184. 2019 · study · Temporal status not established

    Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.

    peer_reviewed_research

  185. 2019 · study · Temporal status not established

    Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y).

    peer_reviewed_research

  186. 2019 · study · Temporal status not established

    Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.

    peer_reviewed_research

  187. 2019 · study · Temporal status not established

    A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

    peer_reviewed_research

  188. 2020 · study · Temporal status not established

    The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.

    peer_reviewed_research

  189. 2020 · study · Temporal status not established

    Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.

    peer_reviewed_research

  190. 2020 · study · Temporal status not established

    The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.

    peer_reviewed_research

  191. 2020 · study · Temporal status not established

    High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men.

    peer_reviewed_research

  192. 2020 · study · Temporal status not established

    Murine maternal dietary restriction affects neural Humanin expression and cellular profile.

    peer_reviewed_research

  193. 2020 · study · Temporal status not established

    Assay Development and Measurement of the Aging Biomarker Humanin.

    peer_reviewed_research

  194. 2020 · study · Temporal status not established

    Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration.

    peer_reviewed_research

  195. 2020 · study · Temporal status not established

    Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.

    peer_reviewed_research

  196. 2020 · study · Temporal status not established

    Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.

    peer_reviewed_research

  197. 2020 · study · Temporal status not established

    HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.

    peer_reviewed_research

  198. 2020 · study · Temporal status not established

    Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.

    peer_reviewed_research

  199. 2020 · study · Temporal status not established

    Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.

    peer_reviewed_research

  200. 2020 · study · Temporal status not established

    Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.

    peer_reviewed_research

  201. 2020 · study · Temporal status not established

    Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.

    peer_reviewed_research

  202. 2020 · study · Temporal status not established

    Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.

    peer_reviewed_research

  203. 2020 · study · Temporal status not established

    The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.

    peer_reviewed_research

  204. 2020 · study · Temporal status not established

    [Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.

    peer_reviewed_research

  205. 2020 · study · Temporal status not established

    Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.

    peer_reviewed_research

  206. 2020 · study · Temporal status not established

    Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.

    peer_reviewed_research

  207. 2020 · study · Temporal status not established

    Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP.

    peer_reviewed_research

  208. 2020 · study · Temporal status not established

    Humanin: A mitochondria-derived peptide with emerging properties.

    peer_reviewed_research

  209. 2021 · study · Temporal status not established

    Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases.

    peer_reviewed_research

  210. 2021 · study · Temporal status not established

    The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.

    peer_reviewed_research

  211. 2021 · study · Temporal status not established

    The emerging role of mitochondrial derived peptide humanin in the testis.

    peer_reviewed_research

  212. 2021 · study · Temporal status not established

    Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles.

    peer_reviewed_research

  213. 2021 · study · Temporal status not established

    The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†.

    peer_reviewed_research

  214. 2021 · study · Temporal status not established

    Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.

    peer_reviewed_research

  215. 2021 · study · Temporal status not established

    Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.

    peer_reviewed_research

  216. 2021 · study · Temporal status not established

    [Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.

    peer_reviewed_research

  217. 2021 · study · Temporal status not established

    Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.

    peer_reviewed_research

  218. 2021 · study · Temporal status not established

    Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.

    peer_reviewed_research

  219. 2021 · study · Temporal status not established

    S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.

    peer_reviewed_research

  220. 2021 · study · Temporal status not established

    Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.

    peer_reviewed_research

  221. 2021 · study · Temporal status not established

    The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.

    peer_reviewed_research

  222. 2021 · study · Temporal status not established

    Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.

    peer_reviewed_research

  223. 2021 · study · Temporal status not established

    Humanin: A Potential Treatment for PCOS?

    peer_reviewed_research

  224. 2022 · study · Temporal status not established

    Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.

    peer_reviewed_research

  225. 2022 · study · Temporal status not established

    Cardio-protective role of Humanin in myocardial ischemia-reperfusion.

    peer_reviewed_research

  226. 2022 · study · Temporal status not established

    The protective effects of S14G-humanin on gestational diabetes mellitus symptoms.

    peer_reviewed_research

  227. 2022 · study · Temporal status not established

    The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.

    peer_reviewed_research

  228. 2022 · study · Temporal status not established

    Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

    peer_reviewed_research

  229. 2022 · study · Temporal status not established

    Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.

    peer_reviewed_research

  230. 2022 · study · Temporal status not established

    Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats.

    peer_reviewed_research

  231. 2022 · study · Temporal status not established

    [Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.

    peer_reviewed_research

  232. 2022 · study · Temporal status not established

    Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition.

    peer_reviewed_research

  233. 2022 · study · Temporal status not established

    Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).

    peer_reviewed_research

  234. 2022 · study · Temporal status not established

    Humanin derivative, HNG, enhances neurotransmitter release.

    peer_reviewed_research

  235. 2022 · study · Temporal status not established

    The role of humanin in natural stress tolerance: An underexplored therapeutic avenue.

    peer_reviewed_research

  236. 2022 · study · Temporal status not established

    The role of humanin in the regulation of reproduction.

    peer_reviewed_research

  237. 2022 · study · Temporal status not established

    An evidence of Humanin-like peptide and Humanin mediated cryosurvival of spermatozoa in buffalo bulls.

    peer_reviewed_research

  238. 2022 · study · Temporal status not established

    Cryoprotection of humanin-like peptides in seminal plasma for ejaculated spermatozoa of crossbred bulls.

    peer_reviewed_research

  239. 2022 · study · Temporal status not established

    Humanin and Alzheimer's disease: The beginning of a new field.

    peer_reviewed_research

  240. 2022 · study · Temporal status not established

    Cryoprotectant with a mitochondrial derived peptide, humanin, improves post-thaw quality of buffalo spermatozoa.

    peer_reviewed_research

  241. 2022 · study · Temporal status not established

    Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).

    peer_reviewed_research

  242. 2022 · study · Temporal status not established

    Structural basis of FPR2 in recognition of Aβ<sub>42</sub> and neuroprotection by humanin.

    peer_reviewed_research

  243. 2022 · study · Temporal status not established

    Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

    peer_reviewed_research

  244. 2023 · study · Temporal status not established

    Age-related Changes in Humanin Expression in the Ovarian Tissue of Rat.

    peer_reviewed_research

  245. 2023 · study · Temporal status not established

    A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.

    peer_reviewed_research

  246. 2023 · study · Temporal status not established

    Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.

    peer_reviewed_research

  247. 2023 · study · Temporal status not established

    Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.

    peer_reviewed_research

  248. 2023 · study · Temporal status not established

    Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.

    peer_reviewed_research

  249. 2023 · study · Temporal status not established

    Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.

    peer_reviewed_research

  250. 2023 · study · Temporal status not established

    Intranasal delivery of mitochondrial protein humanin rescues cell death and promotes mitochondrial function in Parkinson's disease.

    peer_reviewed_research

  251. 2023 · study · Temporal status not established

    A novel link between chronic inflammation and humanin regulation in children.

    peer_reviewed_research

  252. 2023 · study · Temporal status not established

    Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.

    peer_reviewed_research

  253. 2023 · study · Temporal status not established

    S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.

    peer_reviewed_research

  254. 2023 · study · Temporal status not established

    S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.

    peer_reviewed_research

  255. 2023 · study · Temporal status not established

    S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.

    peer_reviewed_research

  256. 2023 · study · Temporal status not established

    Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.

    peer_reviewed_research

  257. 2023 · study · Temporal status not established

    Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.

    peer_reviewed_research

  258. 2023 · study · Temporal status not established

    PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.

    peer_reviewed_research

  259. 2023 · study · Temporal status not established

    Humanin and Its Pathophysiological Roles in Aging: A Systematic Review.

    systematic_review_or_meta_analysis

  260. 2023 · study · Temporal status not established

    The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.

    peer_reviewed_research

  261. 2023 · study · Temporal status not established

    Humanin gene expression in subjects with Parkinson's disease.

    peer_reviewed_research

  262. 2023 · study · Temporal status not established

    A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.

    peer_reviewed_research

  263. 2024 · study · Temporal status not established

    Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.

    peer_reviewed_research

  264. 2024 · study · Temporal status not established

    Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study.

    peer_reviewed_research

  265. 2024 · study · Temporal status not established

    SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.

    peer_reviewed_research

  266. 2024 · study · Temporal status not established

    Impaired Expression of Humanin during Adrenocortical Carcinoma.

    peer_reviewed_research

  267. 2024 · study · Temporal status not established

    Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.

    peer_reviewed_research

  268. 2024 · study · Temporal status not established

    Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression.

    peer_reviewed_research

  269. 2024 · study · Temporal status not established

    Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model.

    peer_reviewed_research

  270. 2024 · study · Temporal status not established

    Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology.

    peer_reviewed_research

  271. 2024 · study · Temporal status not established

    Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.

    peer_reviewed_research

  272. 2024 · study · Temporal status not established

    Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in <i>Ex Vivo</i> Cultured Rat Bones.

    peer_reviewed_research

  273. 2024 · study · Temporal status not established

    Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms.

    peer_reviewed_research

  274. 2024 · study · Temporal status not established

    [Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.

    peer_reviewed_research

  275. 2024 · study · Temporal status not established

    [Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.

    peer_reviewed_research

  276. 2024 · study · Temporal status not established

    Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.

    peer_reviewed_research

  277. 2024 · study · Temporal status not established

    Effects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).

    peer_reviewed_research

  278. 2024 · study · Temporal status not established

    Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.

    peer_reviewed_research

  279. 2025 · study · Temporal status not established

    Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.

    peer_reviewed_research

  280. 2025 · study · Temporal status not established

    HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.

    peer_reviewed_research

  281. 2025 · study · Temporal status not established

    The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.

    peer_reviewed_research

  282. 2025 · study · Temporal status not established

    Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.

    peer_reviewed_research

  283. 2025 · study · Temporal status not established

    A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.

    peer_reviewed_research

  284. 2025 · study · Temporal status not established

    Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.

    peer_reviewed_research

  285. 2025 · study · Temporal status not established

    Detection of Mitochondrial-Derived Peptide Humanin in Semen and Reproductive Tract of Caprine Along With Its Relation to Seasonality.

    peer_reviewed_research

  286. 2025 · study · Temporal status not established

    Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.

    peer_reviewed_research

  287. 2025 · study · Temporal status not established

    Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.

    peer_reviewed_research

  288. 2025 · study · Temporal status not established

    Humanin variants aggregate to produce different fibril morphologies.

    peer_reviewed_research

  289. 2025 · study · Temporal status not established

    Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.

    peer_reviewed_research

  290. 2025 · study · Temporal status not established

    S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.

    peer_reviewed_research

  291. 2025 · study · Temporal status not established

    Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.

    peer_reviewed_research

  292. 2026 · study · Temporal status not established

    Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.

    peer_reviewed_research

  293. 2026 · study · Temporal status not established

    Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.

    peer_reviewed_research

  294. 2026 · study · Temporal status not established

    Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.

    peer_reviewed_research

  295. 2026 · study · Temporal status not established

    Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.

    peer_reviewed_research

  296. 2026 · study · Temporal status not established

    Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.

    peer_reviewed_research

  297. 2026 · study · Temporal status not established

    Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.

    peer_reviewed_research

  298. 2026 · study · Temporal status not established

    Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).

    peer_reviewed_research

  299. 2026 · study · Temporal status not established

    Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.

    peer_reviewed_research

  300. 2026 · study · Temporal status not established

    Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.

    peer_reviewed_research

  301. 2026 · study · Temporal status not established

    Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.

    peer_reviewed_research

  302. 2026 · study · Temporal status not established

    Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.

    peer_reviewed_research

  303. 2026 · study · Temporal status not established

    Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.

    peer_reviewed_research

  304. 2026 · study · Temporal status not established

    Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.

    peer_reviewed_research

  305. 2026 · study · Temporal status not established

    S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.

    peer_reviewed_research

  306. 2026 · study · Temporal status not established

    S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.

    peer_reviewed_research

  307. 2026 · study · Temporal status not established

    Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.

    peer_reviewed_research

  308. 2026 · study · Temporal status not established

    [Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].

    peer_reviewed_research

  309. 2026 · study · Temporal status not established

    Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.

    peer_reviewed_research

  310. 2026 · regulatory · Temporal status not established

    Regulatory review: not_approved

    European Union — EMA

  311. 2026 · regulatory · Temporal status not established

    Regulatory review: not_approved

    United States — FDA

  312. Date unavailable · study · Temporal status not established

    Diagnostic Value of Serum Humanin-Like 3 Levels in Multiple Sclerosis Patients with Predominant Optic Nerve and Spinal Cord Involvement: A Preliminary Study.

    other

  313. Date unavailable · study · Temporal status not established

    Mitochondrial stress and mitokines in aging.

    other

  314. Date unavailable · study · Temporal status not established

    Mitochondrial-Derived Peptides Exacerbate Senescence.

    other

  315. Date unavailable · study · Temporal status not established

    Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.

    other

  316. Date unavailable · study · Temporal status not established

    Characterization of the Effects of a Humanin Fragment Peptide (HNF&lt;sub&gt;14&lt;/sub&gt;) in Age-Related Macular Degeneration.

    other

  317. Date unavailable · study · Temporal status not established

    Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.

    other

  318. Date unavailable · study · Temporal status not established

    Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.

    other

  319. Date unavailable · study · Temporal status not established

    Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.

    other

  320. Date unavailable · study · Temporal status not established

    Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats

    other

  321. Date unavailable · study · Temporal status not established

    Renoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats

    other

  322. Date unavailable · study · Temporal status not established

    Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.

    other

  323. Date unavailable · study · Temporal status not established

    Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats

    other

  324. Date unavailable · study · Temporal status not established

    Humanin analogue promotes metabolic reprogramming to protect the ischemic heart

    other

  325. Date unavailable · study · Temporal status not established

    Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.

    other

  326. Date unavailable · study · Temporal status not established

    Diagnostic potential of serum humanin in breast cancer among the Egyptian population.

    other

  327. Date unavailable · study · Temporal status not established

    Mitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin.

    other

  328. Date unavailable · study · Temporal status not established

    Mitochondrial-derived peptides in energy metabolism.

    other

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

What still needs investigation

Claim traceability

No institutional claim record is currently represented for this peptide.

Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.

Connections

Follow the scientific relationships

Connections appear only when they are represented by the project’s underlying records.

Open 3 represented connections ↓

institution

peer_reviewed_research

represented evidence source

institution

other

represented evidence source

institution

systematic_review_or_meta_analysis

represented evidence source

Traceability

Follow the record back to its source

The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.

Source publication state

A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.

Reviewer provenance state

“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.

Domain conclusion → Evidence

Connected

Evidence → Source

Connected

Source → Original record

Connected

Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.

Reconciled for 6 domain conclusions and 0 featured studies.

Detailed study-to-domain mappings and original-source paths appear in the Humanin evidence-governance section.

Inspect the ranked source records

Observational archive

What contributors reported

Observational archive data is intentionally separated from published scientific evidence.

Observational boundary

Insufficient eligible observations are available for display under the current filters.

Insufficient eligible observations are currently represented to display aggregated findings for this peptide.

Regulatory context

Published jurisdictional records

Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.

United States — FDA

Regulator: FDA

not_approved

As of: 9/23/2026 · Temporal status not established

FDA Drugs@FDA database

Research + media

Media connected to this scientific record

Only media explicitly linked through the project’s relationship system appears here.

No scientifically connected media is currently represented for this peptide.

Sources + provenance

Read the scientific record with its boundaries intact

The public record organizes reviewed evidence; it does not establish scientific truth by itself.
Association, mechanism, observation and regulatory status must not be represented as proof of clinical efficacy or safety.
Observational reports describe contributor experiences and cannot establish causation, effectiveness, safety or clinical benefit.
Contradictory and qualifying evidence must remain visible rather than being silently discarded.
Absence of represented evidence is not evidence that research does not exist.
Research gaps identify unresolved questions; they are not negative conclusions.
Regulatory status is distinct from scientific evidence quality.
Media relationships provide context and explanation; they do not increase the strength of scientific evidence.
A section with no represented records is an incomplete project record, not a scientific conclusion.
Researcher and institutional relationships are shown only when supported by represented records and must not be interpreted as rankings or endorsements.

Generated: 11/8/2026, 5:24:44 PM

global evidence atlas

Humanin research, ranked and separated by purpose

This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.

547Discoverable source universe
500Ranked screening records
6Research domains
0Accountably approved conclusions

500 matching records · ranked 2026-09-18

Page 1 of 20

Count reconciliation: 547 discoverable source records match the peptide identity query; 500 are retained in this bounded, ranked screening view; 0 belong to the separate governed layer labeled “Accountably approved conclusions.” Domain totals overlap because one publication may inform several questions.

governance and regulatory context

Humanin: what this atlas does and does not establish

Last checked
2026-09-18
Accountable publication approval
Not yet approved by a named accountable reviewer. Machine screening only.

No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.

Known limitations of this pass

  • no current regulatory record located in governed sources

No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review.

Humanin evidence · ranking key

How evidence is ranked

A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.

A

Practice-defining evidence

Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.

B

Strong supporting evidence

Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.

C

Contextual evidence

Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.

D

Signal-generating evidence

Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.

Tier and confidence answer different questions

Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.

Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.

Suggested citation

  • APA

    World Peptide Foundation. (n.d.). Humanin — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 26, 2026.) https://www.worldpeptidefoundation.org/directory/humanin

  • AMA / Vancouver

    World Peptide Foundation. Humanin — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 26, 2026. https://www.worldpeptidefoundation.org/directory/humanin