archived version — not current
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GHRP-6
Snapshot captured 2026-09-27 — Evidence added or removed
Overview
Synthetic growth-hormone secretagogue and ghrelin-receptor agonist studied in endocrine and metabolic research.
Evidence quality
Source identities are PubMed-resolved and provisionally graded by study design. Full-text findings, bias, applicability, contradictions, and regulatory interpretation remain pending.
Safety concerns
Human evidence is limited; hormonal, appetite, glucose, product-quality, and sport-status contexts matter.
Citations as of this version
- Growth hormone in obesity.
- Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation. — Journal of nanobiotechnology (2025)
- Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms. — Frontiers in pharmacology (2024)
- Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells. — The Journal of cell biology (2024)
- Growth hormone secretagogue peptide-6 enhances oreochromicins transcription and antimicrobial activity in tilapia (Oreochromis sp.). — Fish & shellfish immunology (2021)
- Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study. — International wound journal (2018)
- Growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (BALB/c), tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus). — Vaccine (2017)
- Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke. — Neurological research (2016)
- Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds. — Plastic surgery international (2016)
- [Time course study of growth hormone releasing peptide-6-induced c-fos expression in neurons of feeding-related nuclei of hypothalamus]. — Sheng li xue bao : [Acta physiologica Sinica] (2016)
- Growth hormone-releasing peptide-biotin conjugate stimulates myocytes differentiation through insulin-like growth factor-1 and collagen type I. — BMB reports (2015)
- N-aminoimidazolidin-2-one peptidomimetics. — Organic letters (2014)
- Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. — Molecular and cellular endocrinology (2011)
- Formation of acylated growth hormone-releasing peptide-6 by poly(lactide-co-glycolide) and its biological activity. — AAPS PharmSciTech (2007)
- Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. — Journal of neurochemistry (2006)
- Growth hormone-releasing peptide-6 increases insulin-like growth factor-I mRNA levels and activates Akt in RCA-6 cells as a model of neuropeptide Y neurones. — Journal of neuroendocrinology (2005)
- Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice. — Neurogastroenterology and motility (2004)
- Effects of growth hormone-releasing peptide-6 on the nocturnal secretion of GH, ACTH and cortisol and on the sleep EEG in man: role of routes of administration. — Journal of neuroendocrinology (1999)
- Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation. — The Journal of clinical endocrinology and metabolism (1998)
- Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. — Clinical endocrinology (1997)
- Influence of endogenous cholinergic tone and growth hormone-releasing peptide-6 on exercise induced growth hormone release. — Clinical endocrinology (1997)
- Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency. — Journal of pediatric endocrinology & metabolism : JPEM (1996)
- Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. — Neuroendocrinology (1995)
- Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats. — Life sciences (1995)
- Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells. — Journal of molecular endocrinology (1995)
- GH releasing peptides--structure and kinetics. — The Journal of pediatric endocrinology (1993)
Regulatory status as of this version
- European Union: not_approved
- United States: not_approved
Content hash: cda08bba422168272982adf9b9492467e838f97448c0d1107bfe3d3dfd0826f5