Scientific intelligence record
Experience 2.0
Growth hormone secretagogue peptide
Synthetic growth-hormone secretagogue and ghrelin-receptor agonist studied in endocrine and metabolic research.
Record status
Traceability partial
Last meaningful update: 9/20/2026
Ranked research corpus
500
Categorized publications with transparent machine-proposed ranking; human appraisal pending.
global evidence atlas
This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.
500 matching records · ranked 2026-09-18
Page 1 of 20
Europe PMC · 2026 · PMID 42465868 · DOI 10.3389/fsurg.2026.1859548
human-observational
Europe PMC · 2026 · PMID 41406822 · DOI 10.1016/j.psj.2025.106199
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.1142/s2737416526500626 · DOI 10.1142/s2737416526500626
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.13140/rg.2.2.29803.91680 · DOI 10.13140/rg.2.2.29803.91680
contextual-unclassified
Europe PMC · 2026 · PMID 42753464 · DOI 10.1016/j.tice.2026.103950
laboratory-mechanistic
Europe PMC · 2026 · PMID 42461148 · DOI 10.1530/joe-26-0041
preclinical-animal
Europe PMC · 2026 · PMID 41901314 · DOI 10.3390/ph19030468
preclinical-animal
Europe PMC · 2026 · PMID 41534456 · DOI 10.1016/j.intimp.2026.116204
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.3390/fishes11010033 · DOI 10.3390/fishes11010033
contextual-unclassified
Europe PMC · 2026 · PMID 41520995 · DOI 10.1016/j.peptides.2026.171464
preclinical-animal
OpenAlex · 2026 · Source ID doi:10.1016/j.microc.2026.117406 · DOI 10.1016/j.microc.2026.117406
preclinical-animal
Europe PMC · 2026 · PMID 42352276 · DOI 10.3390/biom16060809
preclinical-animal
Europe PMC · 2026 · PMID 42395176 · DOI 10.3389/fendo.2026.1822475
human-interventional
Europe PMC · 2025 · PMID 40318448 · DOI 10.1016/j.biopha.2025.118093
preclinical-animal
Europe PMC · 2025 · Source ID agr:ind609065098
preclinical-animal
OpenAlex · 2025 · Source ID doi:10.1007/s10499-025-01987-w · DOI 10.1007/s10499-025-01987-w
contextual-unclassified
Europe PMC · 2025 · PMID 41090425 · DOI 10.22074/ijfs.2025.2038272.1745
human-interventional
Europe PMC · 2025 · PMID 41151018 · DOI 10.1021/acs.jmedchem.5c01693
preclinical-animal
Europe PMC · 2025 · PMID 39857727 · DOI 10.3390/biomedicines13010143
preclinical-animal
Europe PMC · 2025 · PMID 40074098 · DOI 10.1016/j.jep.2025.119625
preclinical-animal
OpenAlex · 2025 · Source ID doi:10.1016/j.microc.2025.112788 · DOI 10.1016/j.microc.2025.112788
laboratory-mechanistic
Europe PMC · 2025 · PMID 40065480 · DOI 10.1186/s13567-025-01478-z
preclinical-animal
Europe PMC · 2025 · PMID 40025613 · DOI 10.1186/s42466-025-00371-6
preclinical-animal
Europe PMC · 2025 · PMID 39882695 · DOI 10.1242/jeb.249707
preclinical-animal
WPF seed · 2025 · PMID 41327290 · DOI 10.1183/13993003.00284-2021
laboratory-mechanistic
governance and regulatory context
No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.
Absence of a record in this pass is not proof that no authorization exists. Status must remain jurisdiction-, product-, formulation-, and date-specific.
No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review. 2 correction(s) have been recorded against this atlas's source metadata.
GHRP-6 evidence · ranking key
A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.
Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.
Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.
Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.
Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.
peptide explorer
Evidence-class labeling remains visible even when interactive rendering is unavailable. Representative geometry is not an experimentally determined or predicted biological conformation.
Fully specified molecular identity
D-residues are exact in notation and represented as X in the schematic.
Sources: NIH PubChem — GHRP-6 · reviewed 2026-09-17
APA
World Peptide Foundation. (n.d.). GHRP-6 — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 20, 2026.) https://www.worldpeptidefoundation.org/directory/ghrp-6
AMA / Vancouver
World Peptide Foundation. GHRP-6 — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 20, 2026. https://www.worldpeptidefoundation.org/directory/ghrp-6
Featured tiered studies
0
Cornerstone publications with study-level interpretation, limitations, and tier disclosure.
Research domains
6
Clinical and scientific questions synthesized independently across the evidence atlas.
Governed reviewed evidence
25
Database records promoted through the governed publication workflow—not the corpus total.
Corpus generated 2026-09-18. Counts remain separately labeled to prevent automated screening from being represented as completed human review.
Human experience · separate evidence stream
Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.
Observation is valuable human context. It is not evidence of causation, efficacy, or safety.
Public display gate
n ≥ 20 eligible observations
Exact progress remains private before the threshold.
Intelligence snapshot
A compact view of what is represented, what remains unresolved, and how completely the record can be traced.
Ranked research corpus
500
Categorized screening records; proposed rankings remain pending human appraisal.
Featured tiered studies
0
Cornerstone studies with published study-level interpretation and tier disclosure.
Research domains
6
Independent evidence dossiers covering the major research questions.
Governed reviewed evidence
25
Reviewed database records promoted through the governed publication workflow.
Contradictions
0
Conflicting evidence relationships that remain visible.
Research gaps
1
Questions the current record identifies as unresolved.
Connected media
0
Media records explicitly linked to this scientific record.
What we know
The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.
Reconciled domain conclusions
GHRP-6 no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded conclusion, confidence level, evidence synthesis, limitations, geographic applicability, regulatory interpretation, and research gaps.
Inspect the reconciled evidence atlasPubMed-indexed clinical trial; journal article; randomized controlled trial; research support, u.s. gov't, non-p.h.s.; research support, u.s. gov't, p.h.s. examining growth hormone (gh)-releasing peptide-6 requires endogenous hypothalamic gh-releasing hormone for maximal gh stimulation. Machine-staged source candidate; findings and limitations require accountable review before publication.
Scientific context
Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.
Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.
Explore further
Move from this peptide record into the project's broader evidence, research, comparison, and methodology systems.
Research
Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.
1993 · study · Temporal status not established
The Journal of pediatric endocrinology
1995 · study · Temporal status not established
Neuroendocrinology
1995 · study · Temporal status not established
Life sciences
1995 · study · Temporal status not established
Journal of molecular endocrinology
1996 · study · Temporal status not established
Journal of pediatric endocrinology & metabolism : JPEM
1997 · study · Temporal status not established
Clinical endocrinology
1997 · study · Temporal status not established
Clinical endocrinology
1998 · study · Temporal status not established
The Journal of clinical endocrinology and metabolism
1999 · study · Temporal status not established
Journal of neuroendocrinology
2004 · study · Temporal status not established
Neurogastroenterology and motility
2005 · study · Temporal status not established
Journal of neuroendocrinology
2006 · study · Temporal status not established
Journal of neurochemistry
2007 · study · Temporal status not established
AAPS PharmSciTech
2011 · study · Temporal status not established
Molecular and cellular endocrinology
2014 · study · Temporal status not established
Organic letters
2015 · study · Temporal status not established
BMB reports
2016 · study · Temporal status not established
Plastic surgery international
2016 · study · Temporal status not established
Neurological research
2016 · study · Temporal status not established
Sheng li xue bao : [Acta physiologica Sinica]
2017 · study · Temporal status not established
Vaccine
2018 · study · Temporal status not established
International wound journal
2021 · study · Temporal status not established
Fish & shellfish immunology
2024 · study · Temporal status not established
Frontiers in pharmacology
2024 · study · Temporal status not established
The Journal of cell biology
2025 · study · Temporal status not established
Journal of nanobiotechnology
2026 · regulatory · Temporal status not established
European Union
2026 · regulatory · Temporal status not established
United States
The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.
No institutional claim record is currently represented for this peptide.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
These are bibliographic author identities derived from represented records. Name strings are not proof of unique real-world researcher identity, and publishing organizations are not treated as institutional affiliations.
3 represented evidence records
Years represented: 1993, 1995, 1998
Publishing organizations appearing in records: Life sciences, The Journal of clinical endocrinology and metabolism, The Journal of pediatric endocrinology
2 represented evidence records
Years represented: 1995, 1999
Publishing organizations appearing in records: Journal of neuroendocrinology, Neuroendocrinology
2 represented evidence records
Years represented: 2017, 2021
Publishing organizations appearing in records: Fish & shellfish immunology, Vaccine
2 represented evidence records
Years represented: 2018, 2024
Publishing organizations appearing in records: Frontiers in pharmacology, International wound journal
2 represented evidence records
Years represented: 1996, 1997
Publishing organizations appearing in records: Clinical endocrinology, Journal of pediatric endocrinology & metabolism : JPEM
Connections
Connections appear only when they are represented by the project’s underlying records.
institution
institution
institution
institution
institution
institution
institution
institution
institution
institution
institution
institution
Traceability
The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.
Source publication state
A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.
Reviewer provenance state
“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.
Domain conclusion → Evidence
Connected
Evidence → Source
Connected
Source → Original record
Connected
Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.
Reconciled for 6 domain conclusions and 0 featured studies.
Detailed study-to-domain mappings and original-source paths appear in the GHRP-6 evidence-governance section.
Inspect the ranked source recordsObservational archive
Observational archive data is intentionally separated from published scientific evidence.
Observational boundary
Insufficient eligible observations are available for display under the current filters.
Insufficient eligible observations are currently represented to display aggregated findings for this peptide.
Regulatory context
Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.
European Union
Regulator: Not represented
As of: 9/9/2026 · Temporal status not established
Regulatory context incomplete: regulator.
United States
Regulator: Not represented
As of: 9/9/2026 · Temporal status not established
Regulatory context incomplete: regulator.
Research + media
Only media explicitly linked through the project’s relationship system appears here.
No scientifically connected media is currently represented for this peptide.
Sources + provenance
Generated: 9/24/2026, 3:25:34 AM
Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.
Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.
This is a representative, sequence-derived model ordered by residue position only. It is not the peptide's experimentally determined or predicted biological conformation, and it carries no claim about real bond angles, distances, secondary structure, binding sites, or activity.
PubMed-indexed clinical trial; comparative study; journal article; randomized controlled trial examining influence of endogenous cholinergic tone and growth hormone-releasing peptide-6 on exercise induced growth hormone release. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed clinical trial; comparative study; journal article examining effects of growth hormone-releasing peptide-6 on the nocturnal secretion of gh, acth and cortisol and on the sleep eeg in man: role of routes of administration. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed clinical trial; journal article; randomized controlled trial; research support, non-u.s. gov't examining growth hormone-releasing peptide-6 stimulates sleep, growth hormone, acth and cortisol release in normal man. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed clinical trial; comparative study; journal article; randomized controlled trial; research support, non-u.s. gov't examining growth hormone responses to gh-releasing peptide (ghrp-6) in hypothyroidism. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining growth hormone-releasing peptide 6 enhances the healing process and improves the esthetic outcome of the wounds. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining formation of acylated growth hormone-releasing peptide-6 by poly(lactide-co-glycolide) and its biological activity. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining growth hormone releasing peptide-6 (ghrp-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining growth hormone-releasing peptide 6 (ghrp-6) hydrogel for acute kidney injury therapy via metabolic regulation. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining n-aminoimidazolidin-2-one peptidomimetics. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; review examining growth hormone releasing hexapeptide-6 (ghrp-6) test in the diagnosis of gh-deficiency. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining growth hormone secretagogue peptide-6 enhances oreochromicins transcription and antimicrobial activity in tilapia (oreochromis sp.). Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining growth hormone-releasing peptide-biotin conjugate stimulates myocytes differentiation through insulin-like growth factor-1 and collagen type i. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining [time course study of growth hormone releasing peptide-6-induced c-fos expression in neurons of feeding-related nuclei of hypothalamus]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed comparative study; journal article; research support, u.s. gov't, p.h.s. examining gh releasing peptides--structure and kinetics. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining insulin and growth hormone-releasing peptide-6 (ghrp-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (stz)-induced diabetic rats. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed comparative study; journal article; research support, non-u.s. gov't examining effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (balb/c), tilapia (oreochromis niloticus) and african catfish (clarias gariepinus). Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining growth hormone-releasing peptide-6 increases insulin-like growth factor-i mrna levels and activates akt in rca-6 cells as a model of neuropeptide y neurones. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, n.i.h., extramural; research support, non-u.s. gov't examining calorie restriction activates a gastric notch-foxo1 pathway to expand ghrelin cells. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining growth hormone releasing peptide (ghrp-6) stimulates phosphatidylinositol (pi) turnover in human pituitary somatotroph cells. Machine-staged source candidate; findings and limitations require accountable review before publication.
2 represented evidence records
Years represented: 1996, 1997
Publishing organizations appearing in records: Clinical endocrinology, Journal of pediatric endocrinology & metabolism : JPEM
2 represented evidence records
Years represented: 2017, 2021
Publishing organizations appearing in records: Fish & shellfish immunology, Vaccine
2 represented evidence records
Years represented: 1995, 1999
Publishing organizations appearing in records: Journal of neuroendocrinology, Neuroendocrinology
2 represented evidence records
Years represented: 2006, 2011
Publishing organizations appearing in records: Journal of neurochemistry, Molecular and cellular endocrinology
2 represented evidence records
Years represented: 2006, 2011
Publishing organizations appearing in records: Journal of neurochemistry, Molecular and cellular endocrinology
2 represented evidence records
Years represented: 2006, 2011
Publishing organizations appearing in records: Journal of neurochemistry, Molecular and cellular endocrinology
2 represented evidence records
Years represented: 2017, 2021
Publishing organizations appearing in records: Fish & shellfish immunology, Vaccine