Phase 2CompletedINTERVENTIONAL
A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)
ClinicalTrials.gov · NCT05877547 · Registry updated: 2026-01-12
- Condition / research focus
- Non-alcoholic Fatty Liver Disease; Fatty Liver, Nonalcoholic; NAFLD; Nonalcoholic Fatty Liver Disease; Nonalcoholic Steatohepatitis
- Sponsor
- Merck Sharp & Dohme LLC
- Countries with listed sites
- Austria · Belgium · Canada · Chile · China · Colombia · Czechia · France · Hong Kong · Hungary · Israel · Italy · Japan · Mexico · Peru · Portugal · Puerto Rico · Singapore · South Korea · Spain · Switzerland · Taiwan · Thailand · Turkey (Türkiye) · United Kingdom · United States
- Registry dates and results
- Start: 2023-06-23. Completion: 2025-12-29 (may be estimated). No results posted in this registry response.
Products and interventions (3)
Includes comparators and combinations. A search match is not a verified peptide identity or evidence of benefit.
- Efinopegdutide (drug) — also listed as: MK-6024, HM12525A, JNJ-64565111
- Semaglutide (drug) — also listed as: Wegovy
- Placebo (drug)
Where the study takes place — 175 listed sites
Site status can differ from overall study status. This list includes all reported sites, even when your search specifies one location. Confirm availability and eligibility with the study team through the original record.
- The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 3
Chandler, Arizona, United States
Site recruitment: Not reported - The Institute for Liver Health II dba Arizona Clinical Trials - Peoria ( Site 3289)
Peoria, Arizona, United States
Site recruitment: Not reported - The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 3218)
Tucson, Arizona, United States
Site recruitment: Not reported - Del Sol Research Management, LLC ( Site 3211)
Tucson, Arizona, United States
Site recruitment: Not reported - Om Research - Apple Valley ( Site 3244)
Apple Valley, California, United States
Site recruitment: Not reported - Om Research LLC ( Site 3245)
Camarillo, California, United States
Site recruitment: Not reported - Velocity Clinical Research, Gardena ( Site 3225)
Gardena, California, United States
Site recruitment: Not reported - Velocity Clinical Research, Huntington Park ( Site 3217)
Huntington Park, California, United States
Site recruitment: Not reported - Velocity Clinical Research, San Diego ( Site 3226)
La Mesa, California, United States
Site recruitment: Not reported - Om Research LLC ( Site 3229)
Lancaster, California, United States
Site recruitment: Not reported - Velocity Clinical Research, Westlake ( Site 3216)
Los Angeles, California, United States
Site recruitment: Not reported - Velocity Clinical Research, Panorama City ( Site 3214)
Panorama City, California, United States
Site recruitment: Not reported - California Liver Research Institute ( Site 3232)
Pasadena, California, United States
Site recruitment: Not reported - Clinical Trials Research ( Site 3230)
Sacramento, California, United States
Site recruitment: Not reported - Excel Medical Clinical Trials ( Site 3246)
Boca Raton, Florida, United States
Site recruitment: Not reported - Synergy Healthcare ( Site 3286)
Bradenton, Florida, United States
Site recruitment: Not reported - Synergy Healthcare LLC ( Site 3290)
Brandon, Florida, United States
Site recruitment: Not reported - Top Medical Research ( Site 3209)
Cutler Bay, Florida, United States
Site recruitment: Not reported - Covenant Metabolic Specialists, LLC ( Site 3231)
Fort Myers, Florida, United States
Site recruitment: Not reported - Velocity Clinical Research, Hallandale Beach ( Site 3241)
Hallandale, Florida, United States
Site recruitment: Not reported - Indago Research & Health Center, Inc ( Site 3207)
Hialeah, Florida, United States
Site recruitment: Not reported - Sweet Hope Research Specialty, Inc-Research ( Site 3200)
Hialeah, Florida, United States
Site recruitment: Not reported - Florida Research Institute ( Site 3243)
Lakewood Rch, Florida, United States
Site recruitment: Not reported - Genoma Research Group ( Site 3242)
Miami, Florida, United States
Site recruitment: Not reported - Floridian Clinical Research, LLC ( Site 3203)
Miami Lakes, Florida, United States
Site recruitment: Not reported - Southeast Clinical Research Center ( Site 3288)
Dalton, Georgia, United States
Site recruitment: Not reported - Eagle Clinical Research ( Site 3233)
Chicago, Illinois, United States
Site recruitment: Not reported - University of Iowa ( Site 3213)
Iowa City, Iowa, United States
Site recruitment: Not reported - Kansas City Research Institute ( Site 3249)
Kansas City, Missouri, United States
Site recruitment: Not reported - The Machuca Foundation ( Site 3234)
Las Vegas, Nevada, United States
Site recruitment: Not reported - Velocity Clinical Research, Syracuse ( Site 3227)
East Syracuse, New York, United States
Site recruitment: Not reported - New York Gastroenterology Associates ( Site 3252)
New York, New York, United States
Site recruitment: Not reported - Velocity Clinical Research, Cincinnati ( Site 3237)
Cincinnati, Ohio, United States
Site recruitment: Not reported - Velocity Clinical Research, Providence ( Site 3222)
East Greenwich, Rhode Island, United States
Site recruitment: Not reported - Velocity Clinical Research, Austin ( Site 3235)
Austin, Texas, United States
Site recruitment: Not reported - South Texas Research Institute - Brownsville ( Site 3285)
Brownsville, Texas, United States
Site recruitment: Not reported - Velocity Clinical Research, Dallas ( Site 3220)
Dallas, Texas, United States
Site recruitment: Not reported - Houston Research Institute ( Site 3262)
Houston, Texas, United States
Site recruitment: Not reported - American Research Corporation ( Site 3202)
San Antonio, Texas, United States
Site recruitment: Not reported - Pinnacle Clinical Research ( Site 3284)
San Antonio, Texas, United States
Site recruitment: Not reported - Velocity Clinical Research, Salt Lake City ( Site 3223)
West Jordan, Utah, United States
Site recruitment: Not reported - Gastroenterology Consultants of Southwest Virginia ( Site 3282)
Roanoke, Virginia, United States
Site recruitment: Not reported - Medizinische Universität Graz-Department of Internal Medicine ( Site 0302)
Graz, Styria, Austria
Site recruitment: Not reported - Antwerp University Hospital-Gastr-enterologie/hepatologie ( Site 3300)
Edegem, Antwerpen, Belgium
Site recruitment: Not reported - AZ Maria Middelares-Digestief Centrum ( Site 3301)
Ghent, Oost-Vlaanderen, Belgium
Site recruitment: Not reported - UZ Leuven-Hepatology ( Site 3302)
Leuven, Vlaams-Brabant, Belgium
Site recruitment: Not reported - Heritage Medical Research Clinic ( Site 0403)
Calgary, Alberta, Canada
Site recruitment: Not reported - Vancouver General Hospital-Gastroenterology ( Site 0408)
Vancouver, British Columbia, Canada
Site recruitment: Not reported - Toronto General Hospital ( Site 0402)
Toronto, Ontario, Canada
Site recruitment: Not reported - McGill University Health Centre ( Site 0400)
Montreal, Quebec, Canada
Site recruitment: Not reported - Diex Recherche Quebec Inc. ( Site 0409)
Québec, Quebec, Canada
Site recruitment: Not reported - Enroll SpA ( Site 0501)
Providencia, Region M. de Santiago, Chile
Site recruitment: Not reported - CECIM ( Site 0500)
Santiago, Region M. de Santiago, Chile
Site recruitment: Not reported - Pontificia Universidad Catolica de Chile-CICUC ( Site 0502)
Santiago, Region M. de Santiago, Chile
Site recruitment: Not reported - Beijing Youan Hospital ( Site 0602)
Beijing, Beijing Municipality, China
Site recruitment: Not reported - Beijing Tsinghua Changgung Hospital ( Site 0606)
Beijing, Beijing Municipality, China
Site recruitment: Not reported - Chongqing University Three Gorges Hospital ( Site 0607)
Wanzhou, Chongqing Municipality, China
Site recruitment: Not reported - The First Affiliated Hospital, Sun Yat-sen University ( Site 0603)
Guangzhou, Guangdong, China
Site recruitment: Not reported - Southern Medical University Nanfang Hospital ( Site 0601)
Guangzhou, Guangdong, China
Site recruitment: Not reported - No. 2 Hospital of Nanjing ( Site 0605)
Nanjing, Jiangsu, China
Site recruitment: Not reported - West China Hospital, Sichuan University ( Site 0611)
Chengdu, Sichuan, China
Site recruitment: Not reported - Tianjin Second People's Hospital ( Site 0604)
Tianjin, Tianjin Municipality, China
Site recruitment: Not reported - The First Affiliated Hospital of Wenzhou Medical University ( Site 0609)
Wenzhou, Zhejiang, China
Site recruitment: Not reported - Fundación Centro de Investigación Clínica CIC ( Site 0704)
Medellín, Antioquia, Colombia
Site recruitment: Not reported - Sociedad De Oncología y Hematología Del Cesar SAS ( Site 0708)
Valledupar, Cesar Department, Colombia
Site recruitment: Not reported - Fundacion Santa Fe de Bogota ( Site 0701)
Bogotá, Cundinamarca, Colombia
Site recruitment: Not reported - Solano & Terront Servicios Medicos - UNIENDO ( Site 0705)
Bogotá, Cundinamarca, Colombia
Site recruitment: Not reported - Oncomédica S.A.S ( Site 0702)
Montería, Departamento de Córdoba, Colombia
Site recruitment: Not reported - Fundación Valle del Lili ( Site 0700)
Cali, Valle del Cauca Department, Colombia
Site recruitment: Not reported - KlinMed ( Site 0801)
Prague, Praha 2, Czechia
Site recruitment: Not reported - Krajská nemocnice Liberec ( Site 0800)
Liberec, Czechia
Site recruitment: Not reported - Vseobecna fakultni nemocnice v Praze ( Site 0802)
Prague, Czechia
Site recruitment: Not reported - Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Pôle de Référence Hépato Gastro-entérol
Nice, Alpes-Maritimes, France
Site recruitment: Not reported - CHU Bordeaux Haut-Leveque-Service d'Hépato-gastroentérologie ( Site 0904)
Pessac, Aquitaine, France
Site recruitment: Not reported - Hôpital de la Croix Rousse-Centre de Recherche Clinique ( Site 0911)
Lyon, Auvergne-Rhône-Alpes, France
Site recruitment: Not reported - centre hospitalier lyon sud-Endocrinologie, Diabète et Nutrition ( Site 0906)
Pierre-Bénite, Auvergne-Rhône-Alpes, France
Site recruitment: Not reported - CHU Charles Nicolle ( Site 0910)
Rouen, Haute-Normandie, France
Site recruitment: Not reported - Hôpital Beaujon-Hépatologie ( Site 0908)
Clichy, Hauts-de-Seine, France
Site recruitment: Not reported - Centre Hospitalier Universitaire d'Angers-Hepato Gastroenterology ( Site 0900)
Angers, Maine-et-Loire, France
Site recruitment: Not reported - Centre Hospitalier Universitaire Estaing ( Site 0913)
Clermont-Ferrand, Puy-de-Dome, France
Site recruitment: Not reported - Hôpital Saint Antoine ( Site 0914)
Paris, France
Site recruitment: Not reported - Hopitaux Universitaires Paris Centre-Hopital Cochin-Service HEPATOLOGIE- Recherche Clinique ( Site 0
Paris, France
Site recruitment: Not reported - Prince of Wales Hospital ( Site 1000)
Shatin, Hong Kong
Site recruitment: Not reported - SYNEXUS Magyarország Kft. Eü. ( Site 1110)
Budapest, Hungary
Site recruitment: Not reported - Dél-Pesti Centrumkórház-Hepatologiai Szakrendekő ( Site 1102)
Budapest, Hungary
Site recruitment: Not reported - Barzilai Medical Center ( Site 1306)
Ashkelon, Israel
Site recruitment: Not reported - Rambam Health Care Campus ( Site 1304)
Haifa, Israel
Site recruitment: Not reported - Carmel Hospital ( Site 1305)
Haifa, Israel
Site recruitment: Not reported - Shaare Zedek Medical Center-Liver Unit ( Site 1302)
Jerusalem, Israel
Site recruitment: Not reported - Rabin Medical Center ( Site 1301)
Petah Tikva, Israel
Site recruitment: Not reported - Sheba Medical Center ( Site 1300)
Ramat Gan, Israel
Site recruitment: Not reported - Maccabi Health Services - Ramat Hasharon ( Site 1303)
Ramat HaSharon, Israel
Site recruitment: Not reported - Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Dipartimento di Medicina Interna e Gas
Rome, Lazio, Italy
Site recruitment: Not reported - Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 1403)
Milan, Lombardy, Italy
Site recruitment: Not reported - Humanitas-Medicina interna ed Epatologia ( Site 1400)
Rozzano, Lombardy, Italy
Site recruitment: Not reported - A.O.U. Policlinico Paolo Giaccone-Dep. Of Internal Medicine and Specialistic ( Site 1402)
Palermo, Sicily, Italy
Site recruitment: Not reported - Azienda Ospedaliero-Universitaria Città della Salute e della-S.C. Gastroenterologia U. ( Site 1401)
Torino, Italy
Site recruitment: Not reported - Ehime University Hospital ( Site 1509)
Tōon, Ehime, Japan
Site recruitment: Not reported - Kurume University Hospital ( Site 1504)
Kurume, Fukuoka, Japan
Site recruitment: Not reported - Ogaki Municipal Hospital ( Site 1511)
Ōgaki, Gifu, Japan
Site recruitment: Not reported - Sapporo Kosei General Hospital ( Site 1521)
Sapporo, Hokkaido, Japan
Site recruitment: Not reported - Kagawa University Hospital ( Site 1515)
Kita, Kagawa-ken, Japan
Site recruitment: Not reported - Kagawa Prefectural Central Hospital ( Site 1514)
Takamatsu, Kagawa-ken, Japan
Site recruitment: Not reported - Toranomon Hospital Kajigaya ( Site 1502)
Kawasaki, Kanagawa, Japan
Site recruitment: Not reported - Shinyurigaoka General Hospital ( Site 1518)
Kawasaki, Kanagawa, Japan
Site recruitment: Not reported - St. Marianna University Hospital ( Site 1516)
Kawasaki, Kanagawa, Japan
Site recruitment: Not reported - Yokohama City University Hospital ( Site 1505)
Yokohama, Kanagawa, Japan
Site recruitment: Not reported - Shinshu University Hospital ( Site 1512)
Matsumoto, Nagano, Japan
Site recruitment: Not reported - Nara Medical University Hospital ( Site 1513)
Kashihara, Nara, Japan
Site recruitment: Not reported - Osaka Saiseikai Suita Hospital ( Site 1503)
Suita, Osaka, Japan
Site recruitment: Not reported - Toranomon Hospital ( Site 1501)
Minato-ku, Tokyo, Japan
Site recruitment: Not reported - Fukuiken Saiseikai Hospital ( Site 1507)
Fukui, Japan
Site recruitment: Not reported - Gifu Municipal Hospital ( Site 1506)
Gifu, Japan
Site recruitment: Not reported - University Hospital,Kyoto Prefectural University of Medicine ( Site 1519)
Kyoto, Japan
Site recruitment: Not reported - Kawasaki Medical School General Medical Center ( Site 1508)
Okayama, Japan
Site recruitment: Not reported - Osaka Metropolitan University Hospital ( Site 1520)
Osaka, Japan
Site recruitment: Not reported - Saga University Hospital ( Site 1510)
Saga, Japan
Site recruitment: Not reported - Japanese Red Cross Musashino Hospital ( Site 1517)
Tokyo, Japan
Site recruitment: Not reported - Medica Sur-Clinica de Enfermedades Digestivas y Obesidad ( Site 1603)
Mexico City, Mexico City, Mexico
Site recruitment: Not reported - Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 1604)
Monterrey, Nuevo León, Mexico
Site recruitment: Not reported - Servicios de Oncología Médica Integral - Monterrey ( Site 1611)
Monterrey, Nuevo León, Mexico
Site recruitment: Not reported - ICARO Investigaciones en Medicina ( Site 1608)
Chihuahua City, Mexico
Site recruitment: Not reported - Centro de Investigación y Gastroenterología ( Site 1601)
Cuauhtémoc, Mexico
Site recruitment: Not reported - Centro de Investigación y Gastroenterología - S.C. ( Site 1609)
Mexico City, Mexico
Site recruitment: Not reported - Oaxaca Site Management Organization ( Site 1613)
Oaxaca City, Mexico
Site recruitment: Not reported - Centro de Investigacion Clinica de Oaxaca ( Site 1607)
Oaxaca City, Mexico
Site recruitment: Not reported - Centro de investigacion Clínica Trujillo ( Site 1802)
Trujillo, La Libertad, Peru
Site recruitment: Not reported - CLINICA DELGADO-Clinical Research ( Site 1800)
Miraflores, Lima region, Peru
Site recruitment: Not reported - Instituto Médico Soy Diabetico ( Site 1804)
Piura, Peru
Site recruitment: Not reported - Unidade Local de Saúde do Alto Ave - Hospital Senhora da Oliveira ( Site 1905)
Guimarães, Braga District, Portugal
Site recruitment: Not reported - Unidade Local de Saude Lisboa Ocidental - Hospital Egas Moniz ( Site 1906)
Lisbon, Lisbon District, Portugal
Site recruitment: Not reported - Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 1904)
Lisbon, Lisbon District, Portugal
Site recruitment: Not reported - ULSAM - Hospital de Santa Luzia ( Site 1907)
Viana do Castelo, Portugal
Site recruitment: Not reported - ISIS CLINICAL RESEARCH CENTER ( Site 2006)
Guaynabo, Puerto Rico
Site recruitment: Not reported - Pan American Center for Oncology Trials ( Site 2000)
Rio Piedras, Puerto Rico
Site recruitment: Not reported - Klinical Investigations Group-Clinical Research ( Site 2001)
San Juan, Puerto Rico
Site recruitment: Not reported - Latin Clinical Trial Center ( Site 2004)
San Juan, Puerto Rico
Site recruitment: Not reported - Singapore General Hospital ( Site 2188)
Singapore, Central Singapore, Singapore
Site recruitment: Not reported - Boramae Medical Center-Internal Medicine ( Site 2403)
Dongjak-gu, Seoul, South Korea
Site recruitment: Not reported - Inha University Hospital-Gastroenterolgy/Hepatology ( Site 2402)
Incheon, South Korea
Site recruitment: Not reported - Severance Hospital, Yonsei University Health System ( Site 2401)
Seoul, South Korea
Site recruitment: Not reported - Samsung Medical Center-Gastroenterology/Internal Medicine ( Site 2400)
Seoul, South Korea
Site recruitment: Not reported - Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2506)
Málaga, Andalusia, Spain
Site recruitment: Not reported - Hospital Universitario Marqués de Valdecilla-Gastroenterology and Hepatology ( Site 2505)
Santander, Cantabria, Spain
Site recruitment: Not reported - Hospital General de Tomelloso-Aparato Digestivo ( Site 2514)
Tomelloso, Ciudad Real, Spain
Site recruitment: Not reported - CHUAC-Complejo Hospitalario Universitario A Coruña-Endocrinología ( Site 2511)
A Coruña, La Coruna, Spain
Site recruitment: Not reported - CHUS - Hospital Clinico Universitario ( Site 2503)
Santiago de Compostela, La Coruna, Spain
Site recruitment: Not reported - Hospital Universitario Ramón y Cajal ( Site 2508)
Madrid, Madrid, Comunidad de, Spain
Site recruitment: Not reported - Hospital Universitari Vall d'Hebron-Liver Unit - Department of Internal Medicine ( Site 2507)
Barcelona, Spain
Site recruitment: Not reported - Hospital Universitario La Paz-HEPATOLOGIA ( Site 2509)
Madrid, Spain
Site recruitment: Not reported - HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA-Gastroenterologia y Hepatologia ( Site 2500)
Madrid, Spain
Site recruitment: Not reported - HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Unidad de Ensayos Clínicos de Aparato Digestivo ( Site 2504)
Seville, Spain
Site recruitment: Not reported - Cantonal Hospital St.Gallen-Klinik für Gastroenterologie / Hepatologie ( Site 2601)
Sankt Gallen, Canton of St. Gallen, Switzerland
Site recruitment: Not reported - UniversitätsSpital Zürich-Gastroenterologie & Hepatologie ( Site 2603)
Zurich, Canton of Zurich, Switzerland
Site recruitment: Not reported - Fondazione Epatocentro Ticino ( Site 2602)
Lugano, Canton Ticino, Switzerland
Site recruitment: Not reported - Changhua Christian Hospital-Endocrinology and metabolism ( Site 2704)
Changhua County, Changhua, Taiwan
Site recruitment: Not reported - Chiayi Christian Hospital ( Site 2707)
Chiayi City, Chiayi, Taiwan
Site recruitment: Not reported - Taichung Veterans General Hospital ( Site 2703)
Taichung, Taiwan
Site recruitment: Not reported - National Cheng Kung University Hospital-Liver Research team of National Cheng Kung University Hospi
Tainan, Taiwan
Site recruitment: Not reported - National Taiwan University Hospital-Internal Medicine ( Site 2700)
Taipei, Taiwan
Site recruitment: Not reported - Taipei Veterans General Hospital-Division of Gastroenterology & Hepatology, Department of Medicine (
Taipei, Taiwan
Site recruitment: Not reported - Chang Gung Medical Foundation-Linkou Branch ( Site 2702)
Taoyuan, Taiwan
Site recruitment: Not reported - Chulalongkorn University ( Site 2800)
Bangkok, Bangkok, Thailand
Site recruitment: Not reported - Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 2802)
Bangkok, Bangkok, Thailand
Site recruitment: Not reported - Maharaj Nakorn Chiang Mai Hospital ( Site 2801)
Muang, Chiang Mai, Thailand
Site recruitment: Not reported - Hacettepe Universite Hastaneleri-internal diseases ( Site 2901)
Ankara, Turkey (Türkiye)
Site recruitment: Not reported - Bezmialem Vakf Üniversitesi-Gastroenterology ( Site 2903)
Istanbul, Turkey (Türkiye)
Site recruitment: Not reported - T.C. Sağlik Bakanliği- Marmara Üniversitesi İstanbul Pendik -T.C. Sağlik Bakanliği- Marmara Ünivers
Istanbul, Turkey (Türkiye)
Site recruitment: Not reported - Dokuz Eylul Universitesi Hastanesi-Gastroenterology ( Site 2905)
Izmir, Turkey (Türkiye)
Site recruitment: Not reported - Recep Tayyip Erdogan University Training and Research Hospital ( Site 2900)
Rize, Turkey (Türkiye)
Site recruitment: Not reported - Royal London Hospital ( Site 3003)
London, England, United Kingdom
Site recruitment: Not reported - King's College Hospital ( Site 3002)
London, London, City of, United Kingdom
Site recruitment: Not reported - Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 3004)
Aberdeen, Scotland, United Kingdom
Site recruitment: Not reported - Queen Elizabeth Hospital Birmingham ( Site 3000)
Birmingham, Warwickshire, United Kingdom
Site recruitment: Not reported - St James's University Hospital ( Site 3005)
Leeds, United Kingdom
Site recruitment: Not reported