Research Atlas · source screening

Taltirelin

An attributable first-pass index of PubMed records whose titles name this governed identity. Records are sorted by publication date, not by evidence strength. Inclusion does not establish efficacy, safety, or a clinical indication.

Scope: Single-source, name-in-title discovery sample. Not a systematic review, worldwide source coverage, clinical appraisal, efficacy or safety conclusion, or complete WPF profile. This source index is separate from the Public Peptide Directory and from human observations.

Title-search results: 37
Shown with stable PMIDs: 25
Search recorded: 2026-09-26

Source: NCBI PubMed / MEDLINE · exact query: "Taltirelin"[Title] · up to 25 recent title matches per identity. Each result links to its PubMed record.

Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration.
J Mov Disord · 2026 Apr · PMID 41714866 · DOI 10.14802/jmd.24127e
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Effects of nucleation on solvate and polymorph control - evaporative crystallization of taltirelin.
RSC Adv · 2026 Mar 9 · PMID 41809083 · DOI 10.1039/d5ra07845h
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Taltirelin treatment alleviates PTSD-like symptoms and restores neural oscillations in male mice receiving single prolonged stress.
Neuropharmacology · 2026 Feb 15 · PMID 41330489 · DOI 10.1016/j.neuropharm.2025.110791
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration.
J Mov Disord · 2025 Jan · PMID 39428104 · DOI 10.14802/jmd.24127
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons.
J Transl Med · 2024 Dec 30 · PMID 39736794 · DOI 10.1186/s12967-024-06020-x
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Thyrotropin-Releasing Hormone Analog Taltirelin Inhibits Acute and Chronic Itch in Mice.
Biol Pharm Bull · 2024 · PMID 39603612 · DOI 10.1248/bpb.b24-00449
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness.
Sci Rep · 2023 Jul 29 · PMID 37516800 · DOI 10.1038/s41598-023-39562-z
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depression.
Br J Anaesth · 2022 Jul · PMID 35459532 · DOI 10.1016/j.bja.2022.03.022
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression?
Pharmacol Res Perspect · 2022 Jun · PMID 35621218 · DOI 10.1002/prp2.974
Source metadata only · evidence grade unassigned · scientific conclusions pending review
β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and Taltirelin.
Cells · 2022 Apr 27 · PMID 35563779 · DOI 10.3390/cells11091473
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Differential activating effects of thyrotropin-releasing hormone and its analog taltirelin on motor output to the tongue musculature in vivo.
Sleep · 2020 Sep 14 · PMID 32227104 · DOI 10.1093/sleep/zsaa053
Source metadata only · evidence grade unassigned · scientific conclusions pending review
TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.
Front Cell Neurosci · 2018 · PMID 30618632 · DOI 10.3389/fncel.2018.00485
Source metadata only · evidence grade unassigned · scientific conclusions pending review
TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.
Front Cell Neurosci · 2018 · PMID 30555300 · DOI 10.3389/fncel.2018.00417
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats.
J Pharmacol Exp Ther · 2018 Jul · PMID 29674333 · DOI 10.1124/jpet.118.248377
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.
Pharmacol Res · 2017 Oct · PMID 28720519 · DOI 10.1016/j.phrs.2017.07.012
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice.
Neuropsychopharmacology · 2013 May · PMID 23303050 · DOI 10.1038/npp.2012.256
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor.
Front Endocrinol (Lausanne) · 2012 · PMID 23087672 · DOI 10.3389/fendo.2012.00120
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Reversal of hemorrhagic shock in rats using the metabolically stable thyrotropin-releasing hormone analog taltirelin hydrate.
J Recept Signal Transduct Res · 2011 Dec · PMID 22044177 · DOI 10.3109/10799893.2011.625427
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
Brain Res · 2011 Sep 26 · PMID 21872219 · DOI 10.1016/j.brainres.2011.07.065
Source metadata only · evidence grade unassigned · scientific conclusions pending review
The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems.
Br J Pharmacol · 2007 Feb · PMID 17220907 · DOI 10.1038/sj.bjp.0707125
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats.
Pharmacol Biochem Behav · 2005 Dec · PMID 16368129 · DOI 10.1016/j.pbb.2005.11.004
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Taltirelin improves motor ataxia independently of monoamine levels in rolling mouse nagoya, a model of spinocerebellar atrophy.
Biol Pharm Bull · 2005 Dec · PMID 16327158 · DOI 10.1248/bpb.28.2244
Source metadata only · evidence grade unassigned · scientific conclusions pending review
[A quantitative evaluation of spinocerebellar degeneration by an acoustic analysis--the effect of taltirelin hydrate on patients with Machado-Joseph disease].
Rinsho Shinkeigaku · 2003 Apr · PMID 12884823
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice.
Life Sci · 2002 Dec 20 · PMID 12467901 · DOI 10.1016/s0024-3205(02)02268-3
Source metadata only · evidence grade unassigned · scientific conclusions pending review
Determination of taltirelin, a new stable thyrotropin-releasing hormone analogue, in human plasma by high-performance liquid chromatography turbo-ionspray ionization tandem mass spectrometry.
J Pharm Biomed Anal · 2002 Nov 7 · PMID 12408927 · DOI 10.1016/s0731-7085(02)00396-5
Source metadata only · evidence grade unassigned · scientific conclusions pending review

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