Scientific intelligence record
Experience 2.0
Synthetic regulatory peptide
Synthetic ACTH-fragment-derived heptapeptide studied chiefly in Russian-language neurobiology and clinical literature.
Record status
Traceability partial
Last meaningful update: 9/20/2026
Ranked research corpus
291
Categorized publications with transparent machine-proposed ranking; human appraisal pending.
global evidence atlas
This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.
291 matching records · ranked 2026-09-18
Page 1 of 12
Europe PMC · 2026 · PMID 42074872 · DOI 10.3390/jcm15083070
human-observational
WPF seed · 2026 · PMID 41490200 · DOI 10.4155/fdd-2022-0009
laboratory-mechanistic
Europe PMC · 2026 · PMID 41490200 · DOI 10.5435/jaaosglobal-d-25-00236
human-interventional
WPF seed · 2026 · PMID 42021992 · DOI 10.1038/s41392-022-00904-4
laboratory-mechanistic
Europe PMC · 2026 · PMID 42021992 · DOI 10.3389/fragi.2026.1790247
human-interventional
Europe PMC · 2026 · PMID 42366656 · DOI 10.17116/oftalma202614203129
preclinical-animal
Europe PMC · 2025 · Source ID doi:10.12688/f1000research.127413.2 · DOI 10.12688/f1000research.127413.2
preclinical-animal
Europe PMC · 2025 · PMID 40650034 · DOI 10.3390/ijms26136256
preclinical-animal
WPF seed · 2025 · PMID 40650034 · DOI 10.1101/gr.1239303
preclinical-animal
Europe PMC · 2025 · PMID 41004910 · DOI 10.1016/j.npep.2025.102563
human-interventional
OpenAlex · 2025 · Source ID openalex:w7110513382
laboratory-mechanistic
WPF seed · 2025 · PMID 40692165 · DOI 10.1111/bph.70122
preclinical-animal
Europe PMC · 2025 · PMID 40496623 · DOI 10.1155/bca/4226220
preclinical-animal
Europe PMC · 2025 · PMID 41171324 · DOI 10.1007/s10517-025-06501-z
preclinical-animal
WPF seed · 2025 · PMID 41479572 · DOI 10.32607/actanaturae.27808
preclinical-animal
WPF seed · 2024 · PMID 39767736 · DOI 10.1038/s41598-022-20623-8
preclinical-animal
Europe PMC · 2024 · PMID 39767736 · DOI 10.3390/biomedicines12122830
preclinical-animal
Europe PMC · 2024 · PMID 39442746 · DOI 10.1016/j.ejphar.2024.177068
preclinical-animal
Europe PMC · 2024 · PMID 39418522 · DOI 10.1134/s0006297924090104
preclinical-animal
OpenAlex · 2023 · Source ID doi:10.12775/jehs.2023.13.04.046 · DOI 10.12775/jehs.2023.13.04.046
preclinical-animal
Europe PMC · 2023 · Source ID doi:10.12688/f1000research.127413.1 · DOI 10.12688/f1000research.127413.1
preclinical-animal
OpenAlex · 2023 · Source ID doi:10.31857/s0869813923010053 · DOI 10.31857/s0869813923010053
contextual-unclassified
OpenAlex · 2023 · Source ID doi:10.1134/s0022093023010179 · DOI 10.1134/s0022093023010179
preclinical-animal
OpenAlex · 2023 · Source ID doi:10.1134/s1819712423020137 · DOI 10.1134/s1819712423020137
preclinical-animal
OpenAlex · 2023 · Source ID doi:10.18699/ssmj20230304 · DOI 10.18699/ssmj20230304
preclinical-animal
governance and regulatory context
No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.
Absence of a record in this pass is not proof that no authorization exists. Status must remain jurisdiction-, product-, formulation-, and date-specific.
No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review.
Semax evidence · ranking key
A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.
Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.
Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.
Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.
Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.
APA
World Peptide Foundation. (n.d.). Semax — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 20, 2026.) https://www.worldpeptidefoundation.org/directory/semax
AMA / Vancouver
World Peptide Foundation. Semax — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 20, 2026. https://www.worldpeptidefoundation.org/directory/semax
Featured tiered studies
0
Cornerstone publications with study-level interpretation, limitations, and tier disclosure.
Research domains
5
Clinical and scientific questions synthesized independently across the evidence atlas.
Governed reviewed evidence
25
Database records promoted through the governed publication workflow—not the corpus total.
Corpus generated 2026-09-18. Counts remain separately labeled to prevent automated screening from being represented as completed human review.
Human experience · separate evidence stream
Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.
Observation is valuable human context. It is not evidence of causation, efficacy, or safety.
Public display gate
n ≥ 20 eligible observations
Exact progress remains private before the threshold.
Intelligence snapshot
A compact view of what is represented, what remains unresolved, and how completely the record can be traced.
Ranked research corpus
291
Categorized screening records; proposed rankings remain pending human appraisal.
Featured tiered studies
0
Cornerstone studies with published study-level interpretation and tier disclosure.
Research domains
5
Independent evidence dossiers covering the major research questions.
Governed reviewed evidence
25
Reviewed database records promoted through the governed publication workflow.
Contradictions
0
Conflicting evidence relationships that remain visible.
Research gaps
1
Questions the current record identifies as unresolved.
Connected media
0
Media records explicitly linked to this scientific record.
What we know
The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.
Reconciled domain conclusions
Semax no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded conclusion, confidence level, evidence synthesis, limitations, geographic applicability, regulatory interpretation, and research gaps.
Inspect the reconciled evidence atlasPubMed-indexed clinical trial; journal article examining [the efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; review examining therapeutic peptides in orthopaedics: applications, challenges, and future directions. Machine-staged source candidate; findings and limitations require accountable review before publication.
Scientific context
Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.
Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.
Explore further
Move from this peptide record into the project's broader evidence, research, comparison, and methodology systems.
Research
Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.
2006 · study · Temporal status not established
Izvestiia Akademii nauk. Seriia biologicheskaia
2008 · study · Temporal status not established
Vestnik Rossiiskoi akademii meditsinskikh nauk
2010 · study · Temporal status not established
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
2013 · study · Temporal status not established
Journal of molecular neuroscience : MN
2014 · study · Temporal status not established
Pharmacotherapy
2014 · study · Temporal status not established
BMC genomics
2016 · study · Temporal status not established
Molekuliarnaia genetika, mikrobiologiia i virusologiia
2017 · study · Temporal status not established
Bulletin of experimental biology and medicine
2017 · study · Temporal status not established
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2017 · study · Temporal status not established
Molecular genetics and genomics : MGG
2018 · study · Temporal status not established
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2018 · study · Temporal status not established
Current pharmaceutical design
2020 · study · Temporal status not established
Bulletin of experimental biology and medicine
2020 · study · Temporal status not established
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
2020 · study · Temporal status not established
Genes
2021 · study · Temporal status not established
Current reviews in clinical and experimental pharmacology
2021 · study · Temporal status not established
International journal of molecular sciences
2021 · study · Temporal status not established
Neuropeptides
2021 · study · Temporal status not established
Molekuliarnaia biologiia
2024 · study · Temporal status not established
Biomedicines
2025 · study · Temporal status not established
International journal of molecular sciences
2025 · study · Temporal status not established
Acta naturae
2025 · study · Temporal status not established
British journal of pharmacology
2026 · study · Temporal status not established
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
2026 · study · Temporal status not established
Frontiers in aging
2026 · regulatory · Temporal status not established
European Union
2026 · regulatory · Temporal status not established
United States
The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.
No institutional claim record is currently represented for this peptide.
Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.
These are bibliographic author identities derived from represented records. Name strings are not proof of unique real-world researcher identity, and publishing organizations are not treated as institutional affiliations.
7 represented evidence records
Years represented: 2013, 2014, 2017, 2020, 2021, 2024, 2025
Publishing organizations appearing in records: BMC genomics, Biomedicines, Genes, International journal of molecular sciences, Journal of molecular neuroscience : MN, Molecular genetics and genomics : MGG
6 represented evidence records
Years represented: 2013, 2014, 2017, 2020, 2024, 2025
Publishing organizations appearing in records: BMC genomics, Biomedicines, Genes, International journal of molecular sciences, Journal of molecular neuroscience : MN, Molecular genetics and genomics : MGG
5 represented evidence records
Years represented: 2016, 2017, 2020, 2021, 2025
Publishing organizations appearing in records: Acta naturae, Bulletin of experimental biology and medicine, Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, Molekuliarnaia biologiia, Molekuliarnaia genetika, mikrobiologiia i virusologiia
5 represented evidence records
Years represented: 2013, 2014, 2017, 2024, 2025
Publishing organizations appearing in records: BMC genomics, Biomedicines, International journal of molecular sciences, Journal of molecular neuroscience : MN, Molecular genetics and genomics : MGG
Connections
Connections appear only when they are represented by the project’s underlying records.
institution
institution
institution
institution
institution
institution
institution
institution
institution
institution
institution
institution
Traceability
The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.
Source publication state
A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.
Reviewer provenance state
“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.
Domain conclusion → Evidence
Connected
Evidence → Source
Connected
Source → Original record
Connected
Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.
Reconciled for 5 domain conclusions and 0 featured studies.
Detailed study-to-domain mappings and original-source paths appear in the Semax evidence-governance section.
Inspect the ranked source recordsObservational archive
Observational archive data is intentionally separated from published scientific evidence.
Observational boundary
Insufficient eligible observations are available for display under the current filters.
Insufficient eligible observations are currently represented to display aggregated findings for this peptide.
Regulatory context
Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.
European Union
Regulator: Not represented
As of: 9/9/2026 · Temporal status not established
Regulatory context incomplete: regulator.
United States
Regulator: Not represented
As of: 9/9/2026 · Temporal status not established
Regulatory context incomplete: regulator.
Research + media
Only media explicitly linked through the project’s relationship system appears here.
No scientifically connected media is currently represented for this peptide.
Sources + provenance
Generated: 9/24/2026, 3:24:18 AM
Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.
Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.
PubMed-indexed journal article; research support, non-u.s. gov't; review examining pharmacological aspects of neuro-immune interactions. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining the influence of selank on the level of cytokines under the conditions of "social" stress. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; review examining [possible role of transthyretin in the biological mechanism of the regulatory peptide neuroprotection.]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed comparative study; journal article; review examining [comparison of anticoagulant effects of regulatory proline-containing oligopeptides. specificity of glyprolines, semax, and selank and potential of their practical application]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; review examining therapeutic peptides in gerontology: mechanisms and applications for healthy aging. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining influence of actg4-7-pgp (semax) on morphofunctional state of hepatocytes in chronic emotional and painful stress. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining correction of lipid metabolism disorders in diabetes mellitus with peptide drugs. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining [a comparative chemoreactome analysis of mexidol]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; review examining sigmoidal maximal effect modeling of low-density lipoprotein cholesterol concentration and annual incidence of coronary heart disease events in secondary prevention trials. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed english abstract; journal article; review examining [evolution of the stress concept]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed english abstract; journal article examining [nootropic and analgesic effects of semax following different routes of administration]. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining functional connectomic approach to studying selank and semax effects. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining effect of semax and its c-terminal fragment pro-gly-pro on the expression of vegf family genes and their receptors in experimental focal ischemia of the rat brain. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining brain protein expression profile confirms the protective effect of the acth(4-7)pgp peptide (semax) in a rat model of cerebral ischemia-reperfusion. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining semax, synthetic acth(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining acth-like peptides compensate rat brain gene expression profile disrupted by ischemia a day after experimental stroke. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining semax, an analog of acth(4-7), regulates expression of immune response genes during ischemic brain injury in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining the peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining genes that associated with action of acth-like peptides with neuroprotective potential in rat brain regions with different degrees of ischemic damage. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining the potential of the peptide drug semax and its derivative for correcting pathological impairments in the animal model of alzheimer's disease. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining semax peptide targets the μ opioid receptor gene oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article; research support, non-u.s. gov't examining novel insights into the protective properties of acth(4-7)pgp (semax) peptide at the transcriptome level following cerebral ischaemia-reperfusion in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.
PubMed-indexed journal article examining [the peptide drug acth(4-7)pgp (semax) suppresses mrna transcripts encoding proinflammatory mediators induced by reversible ischemia of the rat brain]. Machine-staged source candidate; findings and limitations require accountable review before publication.
5 represented evidence records
Years represented: 2013, 2014, 2017, 2020, 2021
Publishing organizations appearing in records: BMC genomics, Genes, International journal of molecular sciences, Journal of molecular neuroscience : MN, Molecular genetics and genomics : MGG
5 represented evidence records
Years represented: 2020, 2021, 2024, 2025
Publishing organizations appearing in records: Biomedicines, Genes, International journal of molecular sciences, Molekuliarnaia biologiia
4 represented evidence records
Years represented: 2020, 2021, 2024, 2025
Publishing organizations appearing in records: Biomedicines, Genes, International journal of molecular sciences
4 represented evidence records
Years represented: 2020, 2021, 2024, 2025
Publishing organizations appearing in records: Biomedicines, Genes, International journal of molecular sciences
4 represented evidence records
Years represented: 2010, 2016, 2017, 2025
Publishing organizations appearing in records: Acta naturae, Bulletin of experimental biology and medicine, Molekuliarnaia genetika, mikrobiologiia i virusologiia, Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
4 represented evidence records
Years represented: 2020, 2021, 2024, 2025
Publishing organizations appearing in records: Biomedicines, Genes, International journal of molecular sciences
4 represented evidence records
Years represented: 2020, 2021, 2024, 2025
Publishing organizations appearing in records: Biomedicines, Genes, International journal of molecular sciences
3 represented evidence records
Years represented: 2013, 2014, 2017
Publishing organizations appearing in records: BMC genomics, Journal of molecular neuroscience : MN, Molecular genetics and genomics : MGG