Overall rank 201 · Score 100 · 2019 Nov
Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial.
The lancet. Diabetes & endocrinology
Randomized trialAI-recommended Tier AType 2 diabetesDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 202 · Score 99 · 2018 Apr
Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy.
Diabetes, obesity & metabolism
Randomized trialAI-recommended Tier AType 2 diabetesSafetyOphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 203 · Score 99 · 2018 Apr
Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial.
The lancet. Diabetes & endocrinology
Randomized trialAI-recommended Tier AType 2 diabetesSafetyDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 204 · Score 99 · 2018 Jun 1
Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial.
The Journal of clinical endocrinology and metabolism
Randomized trialAI-recommended Tier AType 2 diabetesSafetyDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 205 · Score 99 · 2018 Aug 25
Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial.
Lancet (London, England)
Randomized trialAI-recommended Tier AWeight loss & obesityType 2 diabetesSafety
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 206 · Score 99 · 2020 Aug 18
Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis.
Annals of internal medicine
Meta-analysisAI-recommended Tier AHeart failureOphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains quantitative evidence synthesis with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 207 · Score 99 · 2018 Feb
Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial.
Diabetes care
Randomized trialAI-recommended Tier AType 2 diabetesSafety
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 208 · Score 99 · 2020 Mar
Oral semaglutide for type 2 diabetes: A systematic review and meta-analysis.
Diabetes, obesity & metabolism
Meta-analysisAI-recommended Tier AType 2 diabetes
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains quantitative evidence synthesis with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 209 · Score 99 · 2018 Nov 14
Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.
Science translational medicine
Randomized trialAI-recommended Tier APediatric & adolescent
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 210 · Score 98 · 2017 May
Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial.
The lancet. Diabetes & endocrinology
Randomized trialAI-recommended Tier AType 2 diabetesCardiovascularSafetyDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 211 · Score 98 · 2025 Feb
Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials.
Annals of internal medicine
Systematic reviewAI-recommended Tier BWeight loss & obesitySafetyDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 212 · Score 98 · 2025
Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Obesity Management in Adults With and Without Type 2 Diabetes: A Systematic Review.
Journal of obesity
Systematic reviewAI-recommended Tier BWeight loss & obesityMASH & liverSafety
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 213 · Score 98 · 2017 Apr
Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial.
The lancet. Diabetes & endocrinology
Randomized trialAI-recommended Tier AType 2 diabetesSafetyDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 214 · Score 98 · 2017 May
Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial.
The lancet. Diabetes & endocrinology
Randomized trialAI-recommended Tier AType 2 diabetesSafetyDiscontinuation & regain
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 215 · Score 98 · 2025 Nov 16
GLP-1 receptor agonists and alcohol use disorder: a systematic review.
Alcohol and alcoholism (Oxford, Oxfordshire)
Systematic reviewAI-recommended Tier BMASH & liverReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 216 · Score 98 · 2019 Oct
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
The lancet. Diabetes & endocrinology
Meta-analysisAI-recommended Tier AKidneyHeart failure
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains quantitative evidence synthesis with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 217 · Score 98 · 2017 Aug
Effects of semaglutide on beta cell function and glycaemic control in participants with type 2 diabetes: a randomised, double-blind, placebo-controlled trial.
Diabetologia
Randomized trialAI-recommended Tier AType 2 diabetesPediatric & adolescent
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 218 · Score 98 · 2017 Oct 17
Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.
JAMA
Randomized trialAI-recommended Tier AType 2 diabetesSafety
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Overall rank 219 · Score 98 · 2026 Jun
A Systematic Review Identifying Critical Evidence Gaps in Reporting Dietary Change in Randomized Controlled Trials Prescribing Liraglutide, Semaglutide, or Tirzepatide.
Obesity reviews : an official journal of the International Association for the Study of Obesity
Systematic reviewAI-recommended Tier BPediatric & adolescent
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 220 · Score 98 · 2026 Mar-Apr
Semaglutide and Non-arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Narrative Synthesis.
AACE endocrinology and diabetes
Systematic reviewAI-recommended Tier BOphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 221 · Score 98 · 2026
Clinical Advances in Heart Failure with Preserved Ejection Fraction: A Systematic Review of Therapeutic and Mechanistic Evidence.
Vascular health and risk management
Systematic reviewAI-recommended Tier BHeart failure
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 222 · Score 98 · 2026 Apr-Jun
GLP-1 therapies and hair loss: A systematic review of current evidence and implications for counseling.
Science progress
Systematic reviewAI-recommended Tier BReal-world evidence
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 223 · Score 98 · 2025 Jul
Efficacy and Safety of Glucagon-Like Peptide-1 Agonists for Psychiatric Symptoms: A Systematic Review.
Brain and behavior
Systematic reviewAI-recommended Tier BPediatric & adolescent
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 224 · Score 98 · 2025 Aug
Semaglutide and Non-arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review.
Cureus
Systematic reviewAI-recommended Tier BOphthalmic
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains systematic evidence synthesis with a Tier B recommendation. No experimental retesting was performed or required.
Overall rank 225 · Score 98 · 2017 Sep
Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity.
Diabetes, obesity & metabolism
Randomized trialAI-recommended Tier AWeight loss & obesity
AI appraisal complete: source relevance and evidence-class signals checked from PubMed title/abstract, publication types, and registry metadata. The record remains randomized comparative evidence with a Tier A recommendation. No experimental retesting was performed or required.
Source registry generated 2026-09-17; AI appraisal completed 2026-09-22 under WPF-SGLT-AI-APPRAISAL-1.0. Humans resolve only the three displayed exceptions and record one accountable bundle publication decision. Records can appear in multiple domains; domain totals therefore overlap.