Selank

World Peptide Foundation

Where is Selank being studied?

Find registered human studies, phases, products, recruitment status and reported research locations around the world. Registry search matches are separate from this profile’s reviewed evidence.

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Scientific intelligence record

Experience 2.0

Synthetic regulatory peptide

Synthetic tuftsin-derived heptapeptide studied primarily in Russian-language preclinical and clinical literature.

Record status

Traceability partial

Last meaningful update: 9/20/2026

Evidence searched through:: Not recorded
Assessment updated:: 9/20/2026
Documented human review:: No documented human review recorded
Automated scientific assessment:: None recorded
AI source check:: 9/26/2026

Published source links and profile text pass separate gates. Only a documented human review is labelled as human review; an automated scientific assessment applies deterministic checks, and an AI source check confirms only that a source exists and matches its identifiers. A source count alone does not establish a review.

Evidence coverage has three distinct layers. The corpus count is a transparent screening inventory, the featured set contains study-level tiering and interpretation, and the published-source count contains records promoted through the institutional publication workflow. Source validation, editorial publication, and scientific appraisal are separate decisions; these numbers must not be merged.

Ranked research corpus

116

Categorized publications with provisional ranking; scientific review remains separate.

Featured tiered studies

Cornerstone publications with study-level interpretation, limitations, and tier disclosure.

Research domains

Clinical and scientific questions synthesized independently across the evidence atlas.

Published source records

Database records promoted through the governed publication workflow—not the corpus total.

Corpus generated 2026-09-18. Counts remain separately labeled so screening is not represented as completed review.

Human experience · separate evidence stream

No community pattern is displayed yet

Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.

Observation is valuable human context. It is not evidence of causation, efficacy, or safety.

Public display gate

n ≥ 20 eligible observations

Exact progress remains private before the threshold.

Contribute an observation Archive details

Intelligence snapshot

The state of the record

A compact view of what is represented, what remains unresolved, and how completely the record can be traced.

Ranked research corpus

116

Categorized screening records; proposed rankings remain pending human appraisal.

Featured tiered studies

Cornerstone studies with published study-level interpretation and tier disclosure.

Research domains

Independent evidence dossiers covering the major research questions.

Published source records

Source records published through the governed workflow; this count does not certify scientific conclusions.

Contradictions

Conflicting evidence relationships that remain visible.

Research gaps

Questions the current record identifies as unresolved.

Connected media

Media records explicitly linked to this scientific record.

What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

4 published domain syntheses connected to 0 featured studies

Selank no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded synthesis, confidence level, evidence context, limitations, geographic applicability, regulatory interpretation, and research gaps. Publication of these syntheses is separate from the scientific review status shown above.

Inspect the reconciled evidence atlas

Inspect the published evidence record28 governed records · titles, provenance, and original-source linksOpen records ↓

2014Phase 1–2 human evidence

[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].

PubMed-indexed clinical trial; comparative study; journal article examining [a comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: V E Medvedev; O N Tereshchenko; A Iu Israelian; I K Chobanu; N V Kost; O Iu Sokolov; N F Miasoedov
Source: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
PubMed: 25176261

Open original source

2026Observational human evidence

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

PubMed-indexed journal article; review examining therapeutic peptides in orthopaedics: applications, challenges, and future directions. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Omar F Rahman; Steven J Lee; William A Seeds
Source: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
DOI: 10.4155/fdd-2022-0009
PubMed: 41490200

Open original source

2017Observational human evidence

Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.

PubMed-indexed journal article examining anticoagulant effects of arginine-containing peptides of the glyproline family (his-phe-arg-trp-pro-gly-pro and thr-lys-pro-arg-pro-gly-pro) revealed by thromboelastography. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: E Ya Rogozinskaya; M G Lyapina
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-017-3950-4
PubMed: 29181670

Open original source

2020Observational human evidence

Functional Connectomic Approach to Studying Selank and Semax Effects.

PubMed-indexed journal article examining functional connectomic approach to studying selank and semax effects. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Ya R Panikratova; I S Lebedeva; O Yu Sokolov; A D Rumshiskaya; D A Kupriyanov; N V Kost; N F Myasoedov
Source: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
DOI: 10.1134/S001249662001007X
PubMed: 32342318

Open original source

2017Observational human evidence

Tuftsin - Properties and Analogs.

PubMed-indexed journal article; review examining tuftsin - properties and analogs. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Agnieszka Siebert; Monika Gensicka-Kowalewska; Grzegorz Cholewinski; Krystyna Dzierzbicka
Source: Current medicinal chemistry
DOI: 10.2174/0929867324666170725140826
PubMed: 28745220

Open original source

2021Observational human evidence

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.

PubMed-indexed journal article; research support, non-u.s. gov't examining the influence of selank on the level of cytokines under the conditions of "social" stress. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Yasenyavskaya A Leonidovna; Samotrueva M Aleksandrovna; Tsibizova A Aleksandrovna; Bashkina O Aleksandrovna; Myasoedov N Fedorovich; Andreeva L Aleksandrovna
Source: Current reviews in clinical and experimental pharmacology
DOI: 10.2174/1574884715666200704152810
PubMed: 32621722

Open original source

2020Observational human evidence

The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.

PubMed-indexed journal article examining the occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: an incentive for controlling agencies to prepare for future encounters of the kind. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Celine Vanhee; Antoine Francotte; Steven Janvier; Eric Deconinck
Source: Drug testing and analysis
DOI: 10.1002/dta.2717
PubMed: 31667971

Open original source

2010Observational human evidence

[Experimental optimization of learning and memory processes by selank].

PubMed-indexed journal article examining [experimental optimization of learning and memory processes by selank]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: T P Semenova; I I Kozlovskiĭ; N M Zakharova; M M Kozlovskaia
Source: Eksperimental'naia i klinicheskaia farmakologiia
PubMed: 20919548

Open original source

2008Observational human evidence

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

PubMed-indexed comparative study; journal article examining [immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: O N Uchakina; P N Uchakin; N F Miasoedov; L A Andreeva; V E Shcherbenko; M V Mezentseva; M V Gabaeva; O Iu Sokolov; A A Zozulia; F I Ershov
Source: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
PubMed: 18577961

Open original source

2013Observational human evidence

[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank].

PubMed-indexed journal article examining [transcriptome alteration in hippocampus under the treatment of tuftsin analog selank]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: T A Kolomin; T Iu Agapova; Ia V Agniullin; S I Shram; M I Shadrina; P A Slominskiĭ; S A Limborskaia; I F Miasoedov
Source: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
DOI: 10.7868/s0044467713030052
PubMed: 24450168

Open original source

2016Observational human evidence

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

PubMed-indexed journal article examining selank administration affects the expression of some genes involved in gabaergic neurotransmission. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Anastasiya Volkova; Maria Shadrina; Timur Kolomin; Lyudmila Andreeva; Svetlana Limborska; Nikolay Myasoedov; Petr Slominsky
Source: Frontiers in pharmacology
DOI: 10.1134/S1068162006020099
PubMed: 26924987

Open original source

2018Observational human evidence

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

PubMed-indexed journal article examining peptide-based anxiolytics: the molecular aspects of heptapeptide selank biological activity. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Tatiana V Vyunova; Lioudmila Andreeva; Konstantin Shevchenko; Nikolay Myasoedov
Source: Protein and peptide letters
DOI: 10.2174/0929866525666180925144642
PubMed: 30255741

Open original source

2014Observational human evidence

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

PubMed-indexed journal article; research support, non-u.s. gov't examining the temporary dynamics of inflammation-related genes expression under tuftsin analog selank action. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Timur Kolomin; Marina Morozova; Anastasiya Volkova; Maria Shadrina; Lyudmila Andreeva; Petr Slominsky; Svetlana Limborska; Nikolay Myasoedov
Source: Molecular immunology
DOI: 10.1016/j.molimm.2013.11.002
PubMed: 24291245

Open original source

2003Animal research

The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.

PubMed-indexed comparative study; journal article; research support, non-u.s. gov't examining the optimizing action of the synthetic peptide selank on a conditioned active avoidance reflex in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: I I Kozlovskii; N D Danchev
Source: Neuroscience and behavioral physiology
DOI: 10.1023/a:1024444321191
PubMed: 14552529

Open original source

2019Animal research

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.

PubMed-indexed journal article examining selank, peptide analogue of tuftsin, protects against ethanol-induced memory impairment by regulating of bdnf content in the hippocampus and prefrontal cortex in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: L G Kolik; A V Nadorova; T A Antipova; S V Kruglov; V S Kudrin; A D Durnev
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-019-04588-9
PubMed: 31625062

Open original source

2009Animal research

[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].

PubMed-indexed comparative study; journal article examining [comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with pcpa]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: T P Semenova; I I kozlovskiĭ; N M Zakharova; M M Kozlovskaia
Source: Eksperimental'naia i klinicheskaia farmakologiia
PubMed: 19803361

Open original source

2014Animal research

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].

PubMed-indexed english abstract; journal article; research support, non-u.s. gov't examining [effect of tripeptide pro-gly-pro on rat brain transcriptome in focal ischemia]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: E V Medvedeva; V G Dmitrieva; O V Povarova; S A Limborskaia; V I Skvortsova; N F Miasoedov; L V Dergunova
Source: Molekuliarnaia biologiia
PubMed: 25850296

Open original source

2017Animal research

Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.

PubMed-indexed journal article examining studying the toxic effects of some biologically active peptides on the model of mouse embryonic stem cells. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: A G Kobylyanskii; Yu A Zolotarev; L A Andreeva; I A Grivennikov; N F Myasoedov
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-017-3891-y
PubMed: 29063333

Open original source

2019Animal research

State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.

PubMed-indexed journal article examining state of colon microbiota in rats during chronic restraint stress and selank treatment. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: A Yu Mukhina; O A Medvedeva; M V Svishcheva; A V Shevchenko; N N Efremova; I I Bobyntsev; P V Kalutskii; L A Andreeva; N F Myasoedov
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-019-04496-y
PubMed: 31236882

Open original source

2017Animal research

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

PubMed-indexed journal article examining effect of selank on spontaneous synaptic activity of rat hippocampal ca1 neurons. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: I S Povarov; R V Kondratenko; V I Derevyagin; N F Myasoedov; V G Skrebitsky
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-017-3676-3
PubMed: 28361410

Open original source

2020Animal research

Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.

PubMed-indexed journal article examining morphological changes in the large intestine of rats subjected to chronic restraint stress and treated with selank. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: A Yu Mukhina; E S Mishina; I I Bobyntsev; O A Medvedeva; M V Svishcheva; P V Kalutskii; L A Andreeva; N F Myasoedov
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-020-04868-9
PubMed: 32651826

Open original source

2016Animal research

[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].

PubMed-indexed comparative study; journal article examining [comparison of pharmacological effects of heptapeptide selank after intranasal and intraperitoneal administration to balb/c and c57bl/6 mice.]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: E V Vasil'eva; E A Kondrakhin; R M Salimov; G I Kovalev
Source: Eksperimental'naia i klinicheskaia farmakologiia
PubMed: 29787664

Open original source

2019Animal research

Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.

PubMed-indexed journal article examining effect of selank on morphological parameters of rat liver in chronic foot-shock stress. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: E V Fomenko; I I Bobyntsev; A V Ivanov; A E Belykh; L A Andreeva; N F Myasoedov
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-019-04512-1
PubMed: 31243679

Open original source

2011Animal research

Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.

PubMed-indexed journal article; research support, non-u.s. gov't examining expression of inflammation-related genes in mouse spleen under tuftsin analog selank. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Timur Kolomin; Maria Shadrina; Lyudmila Andreeva; Petr Slominsky; Svetlana Limborska; Nikolay Myasoedov
Source: Regulatory peptides
DOI: 10.1016/j.regpep.2011.05.001
PubMed: 21609736

Open original source

2017Animal research

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.

PubMed-indexed journal article examining peptide selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Anastasiya Kasian; Timur Kolomin; Lyudmila Andreeva; Elena Bondarenko; Nikolay Myasoedov; Petr Slominsky; Maria Shadrina
Source: Behavioural neurology
DOI: 10.17116/jnevro20151156133-40
PubMed: 28280289

Open original source

2017Animal research

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

PubMed-indexed journal article examining effect of selank on functional state of rat hepatocytes under conditions of restraint stress. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: E V Fomenko; I I Bobyntsev; A A Kryukov; A V Ivanov; L A Andreeva; N F Myasoedov
Source: Bulletin of experimental biology and medicine
DOI: 10.1007/s10517-017-3817-8
PubMed: 28853100

Open original source

2017Laboratory research

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

PubMed-indexed journal article examining gaba, selank, and olanzapine affect the expression of genes involved in gabaergic neurotransmission in imr-32 cells. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Elena Filatova; Anastasiya Kasian; Timur Kolomin; Ekaterina Rybalkina; Anelya Alieva; Lyudmila Andreeva; Svetlana Limborska; Nikolay Myasoedov; Galina Pavlova; Petr Slominsky; Maria Shadrina
Source: Frontiers in pharmacology
DOI: 10.1016/0014-2999(96)00066-0
PubMed: 28293190

Open original source

2006Laboratory research

[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].

PubMed-indexed journal article examining [evenly tritium-labeled peptides and their in vivo and in vitro biodegradation]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors: Iu A Zolotarev; A K Dadaian; O V Dolotov; V S Kozik; N V Kost; O Iu Sokolov; E M Dorokhova; V K Meshavkin; L S Inozemtseva; M V Gabaeva; L A Andreeva; L Iu Alfeeva
Source: Bioorganicheskaia khimiia
PubMed: 16637290

Open original source

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

Open chemistry and biological context ↓

Chemical identity

Molecular and structural record

Structured record

Molecular formula: C33H57N11O9
Molecular weight (Da): 751.9
Amino acid sequence: TKPRPGP
InChIKey: JTDTXGMXNXBGBZ-YVQNUOSGSA-N

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

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Research hub

Enter the broader research and intelligence environment.

Methodology

Review project methods, boundaries, and interpretation rules.

Research

How the scientific record is developing

Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.

Research chronology

2003 · study · Temporal status not established
The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.
Neuroscience and behavioral physiology
2006 · study · Temporal status not established
[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].
Bioorganicheskaia khimiia
2008 · study · Temporal status not established
[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2009 · study · Temporal status not established
[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].
Eksperimental'naia i klinicheskaia farmakologiia
2010 · study · Temporal status not established
[Experimental optimization of learning and memory processes by selank].
Eksperimental'naia i klinicheskaia farmakologiia
2011 · study · Temporal status not established
Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.
Regulatory peptides
2013 · study · Temporal status not established
[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank].
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
2014 · study · Temporal status not established
[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2014 · study · Temporal status not established
The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.
Molecular immunology
2014 · study · Temporal status not established
[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].
Molekuliarnaia biologiia
2016 · study · Temporal status not established
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
Frontiers in pharmacology
2016 · study · Temporal status not established
[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].
Eksperimental'naia i klinicheskaia farmakologiia
2017 · study · Temporal status not established
Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.
Bulletin of experimental biology and medicine
2017 · study · Temporal status not established
Tuftsin - Properties and Analogs.
Current medicinal chemistry
2017 · study · Temporal status not established
Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.
Bulletin of experimental biology and medicine
2017 · study · Temporal status not established
Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.
Bulletin of experimental biology and medicine
2017 · study · Temporal status not established
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.
Behavioural neurology
2017 · study · Temporal status not established
Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.
Bulletin of experimental biology and medicine
2017 · study · Temporal status not established
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.
Frontiers in pharmacology
2018 · study · Temporal status not established
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.
Protein and peptide letters
2019 · study · Temporal status not established
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
Bulletin of experimental biology and medicine
2019 · study · Temporal status not established
State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.
Bulletin of experimental biology and medicine
2019 · study · Temporal status not established
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
Bulletin of experimental biology and medicine
2020 · study · Temporal status not established
Functional Connectomic Approach to Studying Selank and Semax Effects.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
2020 · study · Temporal status not established
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.
Drug testing and analysis
2020 · study · Temporal status not established
Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.
Bulletin of experimental biology and medicine
2021 · study · Temporal status not established
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Current reviews in clinical and experimental pharmacology
2026 · study · Temporal status not established
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
2026 · regulatory · Temporal status not established
Regulatory review: not_approved
European Union
2026 · regulatory · Temporal status not established
Regulatory review: not_approved
United States

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

What still needs investigation

Claim traceability

A V Ivanov

2 represented evidence records

Years represented: 2017, 2019

Publishing organizations appearing in records: Bulletin of experimental biology and medicine

Connections

Follow the scientific relationships

Connections appear only when they are represented by the project’s underlying records.

Reviewer provenance state

“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.

Domain conclusion → Evidence

Connected

Evidence → Source

Connected

Source → Original record

Connected

Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.

Reconciled for 4 domain conclusions and 0 featured studies.

Detailed study-to-domain mappings and original-source paths appear in the Selank evidence-governance section.

Inspect the ranked source records

Observational archive

What contributors reported

Observational archive data is intentionally separated from published scientific evidence.

Observational boundary

Insufficient eligible observations are available for display under the current filters.

Insufficient eligible observations are currently represented to display aggregated findings for this peptide.

Regulatory context

Published jurisdictional records

Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.

European Union

Regulator: Not represented

not_approved

As of: 9/9/2026 · Temporal status not established

Regulatory context incomplete: regulator.

EMA medicines portal

United States

Regulator: Not represented

not_approved

As of: 9/9/2026 · Temporal status not established

Regulatory context incomplete: regulator.

FDA compounding safety-risk list

Research + media

Media connected to this scientific record

Only media explicitly linked through the project’s relationship system appears here.

No scientifically connected media is currently represented for this peptide.

Sources + provenance

Read the scientific record with its boundaries intact

The public record organizes reviewed evidence; it does not establish scientific truth by itself.

Association, mechanism, observation and regulatory status must not be represented as proof of clinical efficacy or safety.

Observational reports describe contributor experiences and cannot establish causation, effectiveness, safety or clinical benefit.

Contradictory and qualifying evidence must remain visible rather than being silently discarded.

Absence of represented evidence is not evidence that research does not exist.

Research gaps identify unresolved questions; they are not negative conclusions.

Regulatory status is distinct from scientific evidence quality.

Media relationships provide context and explanation; they do not increase the strength of scientific evidence.

A section with no represented records is an incomplete project record, not a scientific conclusion.

Researcher and institutional relationships are shown only when supported by represented records and must not be interpreted as rankings or endorsements.

Generated: 11/8/2026, 5:24:44 PM

global evidence atlas

Selank research, ranked and separated by purpose

This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.

116Discoverable source universe

116Ranked screening records

4Research domains

0Accountably approved conclusions

SearchDomainEvidence class

Selank: what this atlas does and does not establish

Last checked: 2026-09-18
Accountable publication approval: Not yet approved by a named accountable reviewer. Machine screening only.

No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.

Regulatory status by jurisdiction

Absence of a record in this pass is not proof that no authorization exists. Status must remain jurisdiction-, product-, formulation-, and date-specific.

European Unionnot approvedchecked 2026-09-09
EMA medicines portal
United Statesnot approvedchecked 2026-09-09
FDA compounding safety-risk list

Known limitations of this pass

no patent candidate retained after literal filter

No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review. 1 correction(s) have been recorded against this atlas's source metadata.

Selank evidence · ranking key

How evidence is ranked

A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.

Practice-defining evidence

Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.

Strong supporting evidence

Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.

Contextual evidence

Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.

Signal-generating evidence

Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.

Tier and confidence answer different questions

Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.

Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.

Suggested citation

APA
World Peptide Foundation. (n.d.). Selank — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 20, 2026.) https://www.worldpeptidefoundation.org/directory/selank
AMA / Vancouver
World Peptide Foundation. Selank — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 20, 2026. https://www.worldpeptidefoundation.org/directory/selank

Where is Selank being studied?

Selank

No community pattern is displayed yet

The state of the record

Evidence, claims, and boundaries

4 published domain syntheses connected to 0 featured studies

[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.

Functional Connectomic Approach to Studying Selank and Semax Effects.

Tuftsin - Properties and Analogs.

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.

The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.

[Experimental optimization of learning and memory processes by selank].

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank].

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.

[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].

Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.

State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.

[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].

Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.

Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].

Chemistry and represented biological context

Molecular and structural record

Continue through the research system

Research discovery

How the scientific record is developing

Research chronology

The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.

[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].

[Experimental optimization of learning and memory processes by selank].

Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.

[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank].

[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].

Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.

Tuftsin - Properties and Analogs.

Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.

State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.

Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.

Functional Connectomic Approach to Studying Selank and Semax Effects.

The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.

Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Regulatory review: not_approved

Regulatory review: not_approved

What still needs investigation

Claim traceability

L A Andreeva

Nikolay Myasoedov

Lyudmila Andreeva

Maria Shadrina

Petr Slominsky

Svetlana Limborska

Timur Kolomin

I I Bobyntsev