WORLD PEPTIDEFOUNDATION

Where is Kisspeptin-10 being studied?

Find registered human studies, phases, products, recruitment status and reported research locations around the world. Registry search matches are separate from this profile’s reviewed evidence.

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Scientific intelligence record

Experience 2.0

Kisspeptin fragment

Kisspeptin-10

Bioactive C-terminal kisspeptin fragment that activates KISS1R and hypothalamic-pituitary-gonadal signaling.

Record status

Traceability partial

Last meaningful update: 9/20/2026

Evidence searched through:
Not recorded
Assessment updated:
9/20/2026
Documented human review:
No documented human review recorded
Automated scientific assessment:
None recorded
AI source check:
9/26/2026

Published source links and profile text pass separate gates. Only a documented human review is labelled as human review; an automated scientific assessment applies deterministic checks, and an AI source check confirms only that a source exists and matches its identifiers. A source count alone does not establish a review.

Evidence coverage has three distinct layers. The corpus count is a transparent screening inventory, the featured set contains study-level tiering and interpretation, and the published-source count contains records promoted through the institutional publication workflow. Source validation, editorial publication, and scientific appraisal are separate decisions; these numbers must not be merged.

Ranked research corpus

390

Categorized publications with provisional ranking; scientific review remains separate.

Featured tiered studies

0

Cornerstone publications with study-level interpretation, limitations, and tier disclosure.

Research domains

6

Clinical and scientific questions synthesized independently across the evidence atlas.

Published source records

29

Database records promoted through the governed publication workflow—not the corpus total.

Corpus generated 2026-09-18. Counts remain separately labeled so screening is not represented as completed review.

Human experience · separate evidence stream

No community pattern is displayed yet

Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.

Observation is valuable human context. It is not evidence of causation, efficacy, or safety.

Public display gate

n ≥ 20 eligible observations

Exact progress remains private before the threshold.

Contribute an observationArchive details

Intelligence snapshot

The state of the record

A compact view of what is represented, what remains unresolved, and how completely the record can be traced.

Ranked research corpus

390

Categorized screening records; proposed rankings remain pending human appraisal.

Featured tiered studies

0

Cornerstone studies with published study-level interpretation and tier disclosure.

Research domains

6

Independent evidence dossiers covering the major research questions.

Published source records

29

Source records published through the governed workflow; this count does not certify scientific conclusions.

Contradictions

0

Conflicting evidence relationships that remain visible.

Research gaps

1

Questions the current record identifies as unresolved.

Connected media

0

Media records explicitly linked to this scientific record.

What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

6 published domain syntheses connected to 0 featured studies

Kisspeptin-10 no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded synthesis, confidence level, evidence context, limitations, geographic applicability, regulatory interpretation, and research gaps. Publication of these syntheses is separate from the scientific review status shown above.

Inspect the reconciled evidence atlas
Inspect the published evidence record29 governed records · titles, provenance, and original-source linksOpen records ↓
2021Phase 1–2 human evidence

Safety Evaluation of KP-10 (Metastin 45-54) Following once Daily Intravenous Administration for 14 Days in Dog.

PubMed-indexed journal article; randomized controlled trial, veterinary; research support, n.i.h., extramural examining safety evaluation of kp-10 (metastin 45-54) following once daily intravenous administration for 14 days in dog. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Pramod S Terse; James Peggins; Stephanie B Seminara
Source
International journal of toxicology
DOI
10.1177/10915818211023459
PubMed
34126799
Open original source
2017Observational human evidence

Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion.

PubMed-indexed journal article examining kisspeptin-10 inhibits ohss by suppressing vegf secretion. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Junyu Zhai; Jiansheng Liu; Shigang Zhao; Han Zhao; Zi-Jiang Chen; Yanzhi Du; Weiping Li
Source
Reproduction (Cambridge, England)
DOI
10.1530/REP-17-0268
PubMed
28676533
Open original source
2024Observational human evidence

[Not Available].

PubMed-indexed english abstract; journal article examining [not available]. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Thibo Colpaert; Martijn Risseeuw; Koen Deventer; Peter Van Eenoo
Source
Biomedical chromatography : BMC
DOI
10.1002/bmc.5946
PubMed
38978171
Open original source
2024Observational human evidence

Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.

PubMed-indexed journal article; research support, non-u.s. gov't examining kisspeptin-10 binding to gpr54 in osteoclasts prevents bone loss by activating dusp18-mediated dephosphorylation of src. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Zhenxi Li; Xinghai Yang; Ruifeng Fu; Zhipeng Wu; Shengzhao Xu; Jian Jiao; Ming Qian; Long Zhang; Chunbiao Wu; Tianying Xie; Jiqiang Yao; Zhixiang Wu
Source
Nature communications
DOI
10.1002/jbmr.5650020510
PubMed
38346942
Open original source
2024Observational human evidence

Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.

PubMed-indexed published erratum examining author correction: kisspeptin-10 binding to gpr54 in osteoclasts prevents bone loss by activating dusp18-mediated dephosphorylation of src. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Zhenxi Li; Xinghai Yang; Ruifeng Fu; Zhipeng Wu; Shengzhao Xu; Jian Jiao; Ming Qian; Long Zhang; Chunbiao Wu; Tianying Xie; Jiqiang Yao; Zhixiang Wu
Source
Nature communications
DOI
10.1038/s41467-024-55352-1
PubMed
39702286
Open original source
2018Observational human evidence

Stimulation of growth hormone by kisspeptin antagonists in ewes.

PubMed-indexed journal article examining stimulation of growth hormone by kisspeptin antagonists in ewes. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
J T Smith; A Roseweir; M Millar; I J Clarke; R P Millar
Source
The Journal of endocrinology
DOI
10.1530/JOE-18-0074
PubMed
29549187
Open original source
2018Observational human evidence

Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation.

PubMed-indexed journal article; research support, non-u.s. gov't examining kisspeptin-10 (kp-10) stimulates osteoblast differentiation through gpr54-mediated regulation of bmp2 expression and activation. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Hyo-Eun Son; Kyeong-Min Kim; Eun-Jung Kim; Won-Gu Jang
Source
Scientific reports
DOI
10.1359/jbmr.060109
PubMed
29391507
Open original source
2022Observational human evidence

Effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme.

PubMed-indexed journal article examining effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Y S Qin; J H Bai; S L Zhang; J G Dai; X L Xu; T Feng; Y Q Song; L L Xiao; Y Liu
Source
Animal : an international journal of animal bioscience
DOI
10.1016/j.animal.2022.100509
PubMed
35436648
Open original source
2023Observational human evidence

Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.

PubMed-indexed journal article; research support, non-u.s. gov't examining kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Paulina Radwańska; Małgorzata Gałdyszyńska; Lucyna Piera; Jacek Drobnik
Source
Scientific reports
DOI
10.1172/JCI145889
PubMed
37968564
Open original source
2022Observational human evidence

Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.

PubMed-indexed journal article examining kisspeptin-10 in cryodiluent improves the post-thaw quality of nili-ravi buffalo (bubalus bubalis) bull spermatozoa. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Muhammad Hammad Fayyaz; Syed Murtaza Hassan Andrabi; Muhammad Shafiq Haider; Mubashir Ali Khalique; Syed Aftab Hussain Shah
Source
Andrologia
DOI
10.1111/and.14564
PubMed
36054451
Open original source
2022Observational human evidence

Kisspeptins inhibit human airway smooth muscle proliferation.

PubMed-indexed journal article; research support, n.i.h., extramural examining kisspeptins inhibit human airway smooth muscle proliferation. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Niyati A Borkar; Nilesh Sudhakar Ambhore; Rama Satyanarayana Raju Kalidhindi; Christina M Pabelick; Y S Prakash; Venkatachalem Sathish
Source
JCI insight
DOI
10.1007/s00441-019-02995-y
PubMed
35420998
Open original source
2025Observational human evidence

New Insights in Bovine Follicular Cysts.

PubMed-indexed journal article examining new insights in bovine follicular cysts. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Alice Carbonari; Nicola Antonio Martino; Matteo Burgio; Vincenzo Cicirelli; Lorenza Frattina; Maria Elena Dell'Aquila; Annalisa Rizzo
Source
Reproduction in domestic animals = Zuchthygiene
DOI
10.1016/j.ygcen.2015.04.016
PubMed
40056005
Open original source
2025Observational human evidence

Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy.

PubMed-indexed journal article examining kisspeptin-10 protects against hiv-1 tat-induced blood-brain barrier dysfunction and neuroinflammation via rhoa/rock pathway: implications for hand therapy. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Chao Cheng; Dong Xiong; Fengwei Zheng; Tianze Wang; Weixin Li
Source
Neurotoxicology
DOI
10.1016/j.neuro.2025.07.008
PubMed
40712838
Open original source
2018Observational human evidence

Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control.

PubMed-indexed journal article examining effects of kisspeptin-10 on hypothalamic neuropeptides and neurotransmitters involved in appetite control. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Giustino Orlando; Sheila Leone; Claudio Ferrante; Annalisa Chiavaroli; Adriano Mollica; Azzurra Stefanucci; Giorgia Macedonio; Marilisa Pia Dimmito; Lidia Leporini; Luigi Menghini; Luigi Brunetti; Lucia Recinella
Source
Molecules (Basel, Switzerland)
DOI
10.1006/meth.2001.1262
PubMed
30477219
Open original source
2017Observational human evidence

Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.

PubMed-indexed comparative study; journal article examining mechanistic insights into the more potent effect of kp-54 compared to kp-10 in vivo. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Xavier d'Anglemont de Tassigny; Channa N Jayasena; Kevin G Murphy; Waljit S Dhillo; William H Colledge
Source
PloS one
DOI
10.1210/jc.2015-2332
PubMed
28464043
Open original source
2017Observational human evidence

Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea.

PubMed-indexed journal article examining hypothalamic-pituitary-ovarian axis reactivation by kisspeptin-10 in hyperprolactinemic women with chronic amenorrhea. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Robert P Millar; Charlotte Sonigo; Richard A Anderson; Jyothis George; Luigi Maione; Sylvie Brailly-Tabard; Philippe Chanson; Nadine Binart; Jacques Young
Source
Journal of the Endocrine Society
DOI
10.1210/js.2017-00328
PubMed
29264460
Open original source
2017Animal research

The effects of kisspeptin-10 on serum metabolism and myocardium in rats.

PubMed-indexed journal article examining the effects of kisspeptin-10 on serum metabolism and myocardium in rats. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ying Zhang; Yuanlong Hou; Xiaoyan Wang; Jihui Ping; Zhiyu Ma; Chuan Suo; Zhihai Lei; Xiang Li; Zheng Zhang; Cuicui Jia; Juan Su
Source
PloS one
DOI
10.2527/jas.2013-6829
PubMed
28692647
Open original source
2023Animal research

Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.

PubMed-indexed journal article; research support, n.i.h., extramural examining kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Niyati A Borkar; Nilesh Sudhakar Ambhore; Premanand Balraj; Yogaraj S Ramakrishnan; Venkatachalem Sathish
Source
The Journal of pathology
DOI
10.1002/path.6086
PubMed
37171283
Open original source
2014Animal research

Kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus.

PubMed-indexed journal article; research support, non-u.s. gov't examining kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Toru Yokoyama; Kouichiro Minami; Kiyoshi Terawaki; Kanako Miyano; Junichi Ogata; Takashi Maruyama; Mamoru Takeuchi; Yasuhito Uezono; Yoichi Ueta
Source
Brain research
DOI
10.1016/j.brainres.2014.08.020
PubMed
25130664
Open original source
2025Animal research

Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.

PubMed-indexed journal article; research support, non-u.s. gov't examining kisspeptin-10 ameliorates obesity-diabetes with diverse effects on ileal enteroendocrine cells and pancreatic islet morphology in high-fat fed female mice. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ananyaa Sridhar; Dawood Khan; Rithiga Muthukumar; Swetha Sampathkumar; Nigel Irwin; Peter R Flatt; R Charlotte Moffett
Source
Biomolecules
DOI
10.15277/bjd.2017.148
PubMed
41301510
Open original source
2015Laboratory research

Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition.

PubMed-indexed journal article examining kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Guo-Qing Song; Yi Zhao
Source
Oncology reports
DOI
10.3892/or.2014.3619
PubMed
25420482
Open original source
2022Laboratory research

Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro.

PubMed-indexed journal article examining kisspeptin-10 rescues cholinergic differentiated shsy-5y cells from α-synuclein-induced toxicity in vitro. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Christopher Simon; Tomoko Soga; Nafees Ahemad; Saatheeyavaane Bhuvanendran; Ishwar Parhar
Source
International journal of molecular sciences
DOI
10.1002/prot.10104
PubMed
35563582
Open original source
2015Laboratory research

The effects of kisspeptin-10 on migration and proliferation of endothelial cell.

PubMed-indexed journal article examining the effects of kisspeptin-10 on migration and proliferation of endothelial cell. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Fatemeh Golzar; Shaghayegh Haghjooy Javanmard
Source
Advanced biomedical research
DOI
10.4103/2277-9175.151250
PubMed
25789267
Open original source
2021Laboratory research

Mutual Interactions Between GnRH and Kisspeptin in GnRH- and Kiss-1-Expressing Immortalized Hypothalamic Cell Models.

PubMed-indexed journal article; research support, non-u.s. gov't examining mutual interactions between gnrh and kisspeptin in gnrh- and kiss-1-expressing immortalized hypothalamic cell models. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Haruhiko Kanasaki; Tuvshintugs Tumurbaatar; Zolzaya Tumurgan; Aki Oride; Hiroe Okada; Satoru Kyo
Source
Reproductive sciences (Thousand Oaks, Calif.)
DOI
10.1007/s43032-021-00695-z
PubMed
34268716
Open original source
2022Laboratory research

Kisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246.

PubMed-indexed journal article; research support, non-u.s. gov't examining kisspeptin-10 promotes progesterone synthesis in bovine ovarian granulosa cells via downregulation of microrna-1246. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Lewei Guo; Haoran Xu; Yajun Li; Hongyu Liu; Jing Zhao; Wenfa Lu; Jun Wang
Source
Genes
DOI
10.1016/j.reprotox.2018.12.010
PubMed
35205342
Open original source
Insufficient evidence

Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences.

Source reference associated with Kisspeptin-10. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1055/s-0039-3400253
PubMed
31847024
Open original source
Insufficient evidence

GPR54 and kisspeptin in reproduction.

Source reference associated with Kisspeptin-10. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1093/humupd/dml023
PubMed
16731583
Open original source
Insufficient evidence

Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis.

Source reference associated with Kisspeptin-10. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.1016/j.numecd.2020.02.017
PubMed
32409274
Open original source
Insufficient evidence

Kisspeptin and Cancer: Molecular Interaction, Biological Functions, and Future Perspectives.

Source reference associated with Kisspeptin-10. Source identity and peptide connection confirmed; scientific conclusions and evidence strength have not been assessed in this source-linking step.

Source
other
DOI
10.3389/fendo.2018.00115
PubMed
29662466
Open original source

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

Open chemistry and biological context ↓
Chemical identity

Molecular and structural record

Structured record
Molecular formula
C63H83N17O14
Molecular weight (Da)
1302.4
Amino acid sequence
YNWNSFGLRF-NH2
InChIKey
RITKWYDZSSQNJI-INXYWQKQSA-N

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

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Evidence system

Explore how scientific evidence is represented and reviewed.

Research hub

Enter the broader research and intelligence environment.

Methodology

Review project methods, boundaries, and interpretation rules.

Research

How the scientific record is developing

Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.

Research chronology

  1. 2014 · study · Temporal status not established

    Kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus.

    Brain research

  2. 2015 · study · Temporal status not established

    Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition.

    Oncology reports

  3. 2015 · study · Temporal status not established

    The effects of kisspeptin-10 on migration and proliferation of endothelial cell.

    Advanced biomedical research

  4. 2017 · study · Temporal status not established

    Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion.

    Reproduction (Cambridge, England)

  5. 2017 · study · Temporal status not established

    Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.

    PloS one

  6. 2017 · study · Temporal status not established

    Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea.

    Journal of the Endocrine Society

  7. 2017 · study · Temporal status not established

    The effects of kisspeptin-10 on serum metabolism and myocardium in rats.

    PloS one

  8. 2018 · study · Temporal status not established

    Stimulation of growth hormone by kisspeptin antagonists in ewes.

    The Journal of endocrinology

  9. 2018 · study · Temporal status not established

    Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation.

    Scientific reports

  10. 2018 · study · Temporal status not established

    Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control.

    Molecules (Basel, Switzerland)

  11. 2021 · study · Temporal status not established

    Safety Evaluation of KP-10 (Metastin 45-54) Following once Daily Intravenous Administration for 14 Days in Dog.

    International journal of toxicology

  12. 2021 · study · Temporal status not established

    Mutual Interactions Between GnRH and Kisspeptin in GnRH- and Kiss-1-Expressing Immortalized Hypothalamic Cell Models.

    Reproductive sciences (Thousand Oaks, Calif.)

  13. 2022 · study · Temporal status not established

    Effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme.

    Animal : an international journal of animal bioscience

  14. 2022 · study · Temporal status not established

    Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.

    Andrologia

  15. 2022 · study · Temporal status not established

    Kisspeptins inhibit human airway smooth muscle proliferation.

    JCI insight

  16. 2022 · study · Temporal status not established

    Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro.

    International journal of molecular sciences

  17. 2022 · study · Temporal status not established

    Kisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246.

    Genes

  18. 2023 · study · Temporal status not established

    Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.

    Scientific reports

  19. 2023 · study · Temporal status not established

    Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.

    The Journal of pathology

  20. 2024 · study · Temporal status not established

    [Not Available].

    Biomedical chromatography : BMC

  21. 2024 · study · Temporal status not established

    Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.

    Nature communications

  22. 2024 · study · Temporal status not established

    Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.

    Nature communications

  23. 2025 · study · Temporal status not established

    New Insights in Bovine Follicular Cysts.

    Reproduction in domestic animals = Zuchthygiene

  24. 2025 · study · Temporal status not established

    Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy.

    Neurotoxicology

  25. 2025 · study · Temporal status not established

    Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.

    Biomolecules

  26. 2026 · regulatory · Temporal status not established

    Regulatory review: not_approved

    European Union

  27. 2026 · regulatory · Temporal status not established

    Regulatory review: not_approved

    United States

  28. Date unavailable · study · Temporal status not established

    Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences.

    other

  29. Date unavailable · study · Temporal status not established

    GPR54 and kisspeptin in reproduction.

    other

  30. Date unavailable · study · Temporal status not established

    Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis.

    other

  31. Date unavailable · study · Temporal status not established

    Kisspeptin and Cancer: Molecular Interaction, Biological Functions, and Future Perspectives.

    other

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

What still needs investigation

Claim traceability

No institutional claim record is currently represented for this peptide.

Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.

Researchers represented in the evidence record12 bibliographic identities · open to inspect

These are bibliographic author identities derived from represented records. Name strings are not proof of unique real-world researcher identity, and publishing organizations are not treated as institutional affiliations.

Nilesh Sudhakar Ambhore

2 represented evidence records

Years represented: 2022, 2023

Publishing organizations appearing in records: JCI insight, The Journal of pathology

Niyati A Borkar

2 represented evidence records

Years represented: 2022, 2023

Publishing organizations appearing in records: JCI insight, The Journal of pathology

Venkatachalem Sathish

2 represented evidence records

Years represented: 2022, 2023

Publishing organizations appearing in records: JCI insight, The Journal of pathology

A Roseweir

1 represented evidence record

Years represented: 2018

Publishing organizations appearing in records: The Journal of endocrinology

Adriano Mollica

1 represented evidence record

Years represented: 2018

Publishing organizations appearing in records: Molecules (Basel, Switzerland)

Aki Oride

1 represented evidence record

Years represented: 2021

Publishing organizations appearing in records: Reproductive sciences (Thousand Oaks, Calif.)

Alice Carbonari

1 represented evidence record

Years represented: 2025

Publishing organizations appearing in records: Reproduction in domestic animals = Zuchthygiene

Ananyaa Sridhar

1 represented evidence record

Years represented: 2025

Publishing organizations appearing in records: Biomolecules

Annalisa Chiavaroli

1 represented evidence record

Years represented: 2018

Publishing organizations appearing in records: Molecules (Basel, Switzerland)

Annalisa Rizzo

1 represented evidence record

Years represented: 2025

Publishing organizations appearing in records: Reproduction in domestic animals = Zuchthygiene

Azzurra Stefanucci

1 represented evidence record

Years represented: 2018

Publishing organizations appearing in records: Molecules (Basel, Switzerland)

Channa N Jayasena

1 represented evidence record

Years represented: 2017

Publishing organizations appearing in records: PloS one

Connections

Follow the scientific relationships

Connections appear only when they are represented by the project’s underlying records.

Open 12 represented connections ↓

institution

other

represented evidence source

institution

Nature communications

represented evidence source

institution

Scientific reports

represented evidence source

institution

PloS one

represented evidence source

institution

International journal of toxicology

represented evidence source

institution

Reproduction (Cambridge, England)

represented evidence source

institution

Biomedical chromatography : BMC

represented evidence source

institution

The Journal of endocrinology

represented evidence source

institution

Animal : an international journal of animal bioscience

represented evidence source

institution

Andrologia

represented evidence source

institution

JCI insight

represented evidence source

institution

Reproduction in domestic animals = Zuchthygiene

represented evidence source

Traceability

Follow the record back to its source

The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.

Source publication state

A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.

Reviewer provenance state

“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.

Domain conclusion → Evidence

Connected

Evidence → Source

Connected

Source → Original record

Connected

Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.

Reconciled for 6 domain conclusions and 0 featured studies.

Detailed study-to-domain mappings and original-source paths appear in the Kisspeptin-10 evidence-governance section.

Inspect the ranked source records

Observational archive

What contributors reported

Observational archive data is intentionally separated from published scientific evidence.

Observational boundary

Insufficient eligible observations are available for display under the current filters.

Insufficient eligible observations are currently represented to display aggregated findings for this peptide.

Regulatory context

Published jurisdictional records

Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.

European Union

Regulator: Not represented

not_approved

As of: 9/9/2026 · Temporal status not established

Regulatory context incomplete: regulator.

EMA medicines portal

United States

Regulator: Not represented

not_approved

As of: 9/9/2026 · Temporal status not established

Regulatory context incomplete: regulator.

FDA Drugs@FDA / official FDA record

Research + media

Media connected to this scientific record

Only media explicitly linked through the project’s relationship system appears here.

No scientifically connected media is currently represented for this peptide.

Sources + provenance

Read the scientific record with its boundaries intact

The public record organizes reviewed evidence; it does not establish scientific truth by itself.
Association, mechanism, observation and regulatory status must not be represented as proof of clinical efficacy or safety.
Observational reports describe contributor experiences and cannot establish causation, effectiveness, safety or clinical benefit.
Contradictory and qualifying evidence must remain visible rather than being silently discarded.
Absence of represented evidence is not evidence that research does not exist.
Research gaps identify unresolved questions; they are not negative conclusions.
Regulatory status is distinct from scientific evidence quality.
Media relationships provide context and explanation; they do not increase the strength of scientific evidence.
A section with no represented records is an incomplete project record, not a scientific conclusion.
Researcher and institutional relationships are shown only when supported by represented records and must not be interpreted as rankings or endorsements.

Generated: 11/8/2026, 5:25:15 PM

global evidence atlas

Kisspeptin-10 research, ranked and separated by purpose

This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.

390Discoverable source universe
390Ranked screening records
6Research domains
0Accountably approved conclusions

390 matching records · ranked 2026-09-18

Page 1 of 16

Count reconciliation: 390 discoverable source records match the peptide identity query; 390 are retained in this bounded, ranked screening view; 0 belong to the separate governed layer labeled “Accountably approved conclusions.” Domain totals overlap because one publication may inform several questions.

governance and regulatory context

Kisspeptin-10: what this atlas does and does not establish

Last checked
2026-09-18
Accountable publication approval
Not yet approved by a named accountable reviewer. Machine screening only.

No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.

Regulatory status by jurisdiction

Absence of a record in this pass is not proof that no authorization exists. Status must remain jurisdiction-, product-, formulation-, and date-specific.

Known limitations of this pass

  • no patent candidate retained after literal filter

No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review.

Kisspeptin-10 evidence · ranking key

How evidence is ranked

A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.

A

Practice-defining evidence

Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.

B

Strong supporting evidence

Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.

C

Contextual evidence

Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.

D

Signal-generating evidence

Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.

Tier and confidence answer different questions

Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.

Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.

peptide explorer

Structural visualization and provenance

Evidence-class labeling remains visible even when interactive rendering is unavailable. Representative geometry is not an experimentally determined or predicted biological conformation.

Fully specified molecular identity

Molecular formula
C63H83N17O14
Molecular weight
1302.4 g/mol
Exact identity / sequence notation
H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Identity-defining modifications
  • C-terminal phenylalaninamide
  • Ten-residue active kisspeptin fragment
PubChem CID
16132319
InChIKey
RITKWYDZSSQNJI-INXYWQKQSA-N

Complete amidated decapeptide identity; schematic is not a receptor-bound conformation.

Sources: NIH PubChem — Kisspeptin-10 · reviewed 2026-09-17

Representative sequence-derived model
Structure source
Generated from this record's governed amino-acid sequence
Identifier
Not applicable — not a database structure
Method
Schematic layout ordered by residue position only; not a molecular-dynamics, homology, or fold prediction
Confidence / limitations
Illustrative only. Not physically accurate; carries no structural, binding-site, or activity meaning.
Provenance
WPF governed PeptideChemistry record
Retrieved / last reviewed
2026-09-17

This is a representative, sequence-derived model ordered by residue position only. It is not the peptide's experimentally determined or predicted biological conformation, and it carries no claim about real bond angles, distances, secondary structure, binding sites, or activity.

Suggested citation

  • APA

    World Peptide Foundation. (n.d.). Kisspeptin-10 — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 20, 2026.) https://www.worldpeptidefoundation.org/directory/kisspeptin-10

  • AMA / Vancouver

    World Peptide Foundation. Kisspeptin-10 — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 20, 2026. https://www.worldpeptidefoundation.org/directory/kisspeptin-10