WORLD PEPTIDEFOUNDATION

Where is Human chorionic gonadotropin (hCG) being studied?

Find registered human studies, phases, products, recruitment status and reported research locations around the world. Registry search matches are separate from this profile’s reviewed evidence.

Find studies for Human chorionic gonadotropin (hCG) →Worldwide registry directory
Search this profile’s alternative names

Check the intervention identity in each registry record; aliases and combination products can produce broader matches.

Scientific intelligence record

Experience 2.0

Glycoprotein hormone / peptide-adjacent biologic

Human chorionic gonadotropin (hCG)

Also known as: hCG, chorionic gonadotropin

Placental heterodimeric glycoprotein hormone and LH/CG-receptor agonist; endogenous physiology, diagnostic measurement, authorized products, and nonmedical use are treated separately.

Record status

Traceability partial

Last meaningful update: 9/20/2026

Evidence searched through:
Not recorded
Assessment updated:
9/20/2026
Documented human review:
No documented human review recorded
Automated scientific assessment:
None recorded
AI source check:
9/26/2026

Published source links and profile text pass separate gates. Only a documented human review is labelled as human review; an automated scientific assessment applies deterministic checks, and an AI source check confirms only that a source exists and matches its identifiers. A source count alone does not establish a review.

Evidence coverage has three distinct layers. The corpus count is a transparent screening inventory, the featured set contains study-level tiering and interpretation, and the published-source count contains records promoted through the institutional publication workflow. Source validation, editorial publication, and scientific appraisal are separate decisions; these numbers must not be merged.

Ranked research corpus

500

Categorized publications with provisional ranking; scientific review remains separate.

Featured tiered studies

0

Cornerstone publications with study-level interpretation, limitations, and tier disclosure.

Research domains

6

Clinical and scientific questions synthesized independently across the evidence atlas.

Published source records

25

Database records promoted through the governed publication workflow—not the corpus total.

Corpus generated 2026-09-18. Counts remain separately labeled so screening is not represented as completed review.

Human experience · separate evidence stream

No community pattern is displayed yet

Eligible observations remain below the privacy and reliability threshold. WPF will not convert a handful of reports into a percentage, trend, or clinical claim.

Observation is valuable human context. It is not evidence of causation, efficacy, or safety.

Public display gate

n ≥ 20 eligible observations

Exact progress remains private before the threshold.

Contribute an observationArchive details

Intelligence snapshot

The state of the record

A compact view of what is represented, what remains unresolved, and how completely the record can be traced.

Ranked research corpus

500

Categorized screening records; proposed rankings remain pending human appraisal.

Featured tiered studies

0

Cornerstone studies with published study-level interpretation and tier disclosure.

Research domains

6

Independent evidence dossiers covering the major research questions.

Published source records

25

Source records published through the governed workflow; this count does not certify scientific conclusions.

Contradictions

0

Conflicting evidence relationships that remain visible.

Research gaps

1

Questions the current record identifies as unresolved.

Connected media

0

Media records explicitly linked to this scientific record.

What we know

Evidence, claims, and boundaries

The project separates represented evidence from qualification, contradiction, uncertainty, and what the evidence does not establish.

Reconciled domain conclusions

6 published domain syntheses connected to 0 featured studies

Human chorionic gonadotropin (hCG) no longer relies on the legacy “no public claim” state. Each research domain publishes a bounded synthesis, confidence level, evidence context, limitations, geographic applicability, regulatory interpretation, and research gaps. Publication of these syntheses is separate from the scientific review status shown above.

Inspect the reconciled evidence atlas
Inspect the published evidence record25 governed records · titles, provenance, and original-source linksOpen records ↓
2018Phase 1–2 human evidence

Should intrauterine human chorionic gonadotropin infusions ever be used prior to embryo transfer?

PubMed-indexed controlled clinical trial; journal article examining should intrauterine human chorionic gonadotropin infusions ever be used prior to embryo transfer?. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Michelle Volovsky; Martin Healey; Vivien MacLachlan; Beverley J Vollenhoven
Source
Journal of assisted reproduction and genetics
DOI
10.1093/humrep/des256
PubMed
28948440
Open original source
2017Phase 1–2 human evidence

A study of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer after two or more implantation failures.

PubMed-indexed journal article; randomized controlled trial examining a study of intrauterine infusion of human chorionic gonadotropin (hcg) before frozen-thawed embryo transfer after two or more implantation failures. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Pinxiu Huang; Lihong Wei; Xinlin Li
Source
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
DOI
10.1080/09513590.2016.1207164
PubMed
27449969
Open original source
1999Phase 1–2 human evidence

Preoperative treatment with human chorionic gonadotropin in infancy decreases the severity of proximal hypospadias and chordee.

PubMed-indexed clinical trial; journal article examining preoperative treatment with human chorionic gonadotropin in infancy decreases the severity of proximal hypospadias and chordee. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
S A Koff; V R Jayanthi
Source
The Journal of urology
PubMed
10492232
Open original source
2003Phase 1–2 human evidence

Prospective evaluation of human chorionic gonadotropin in the differentiation of undescended testes from retractile testes.

PubMed-indexed clinical trial; journal article examining prospective evaluation of human chorionic gonadotropin in the differentiation of undescended testes from retractile testes. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Oren F Miller; Jeffrey A Stock; Bartley G Cilento; Irene M McAleer; George W Kaplan
Source
The Journal of urology
DOI
10.1097/01.ju.0000065823.80051.bb
PubMed
12771792
Open original source
1995Phase 1–2 human evidence

Prediction of early pregnancy outcomes.

PubMed-indexed clinical trial; journal article examining prediction of early pregnancy outcomes. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Y S Lin; C H Liu
Source
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
DOI
10.1016/0020-7292(95)80005-w
PubMed
8582515
Open original source
2020Phase 1–2 human evidence

Human chorionic gonadotropin promotes recruitment of regulatory T cells in endometrium by inducing chemokine CCL2.

PubMed-indexed clinical trial; journal article; research support, non-u.s. gov't examining human chorionic gonadotropin promotes recruitment of regulatory t cells in endometrium by inducing chemokine ccl2. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Xiaomin Huang; Yunni Cai; Min Ding; Bo Zheng; Haixiang Sun; Jianjun Zhou
Source
Journal of reproductive immunology
DOI
10.1016/j.jri.2019.102856
PubMed
31809964
Open original source
2013Phase 1–2 human evidence

Medical abortion follow-up with serum human chorionic gonadotropin compared with ultrasonography: a randomized controlled trial.

PubMed-indexed comparative study; journal article; randomized controlled trial; research support, non-u.s. gov't examining medical abortion follow-up with serum human chorionic gonadotropin compared with ultrasonography: a randomized controlled trial. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ila Dayananda; Rie Maurer; Jennifer Fortin; Alisa B Goldberg
Source
Obstetrics and gynecology
DOI
10.1097/AOG.0b013e3182839fda
PubMed
23635625
Open original source
2024Phase 1–2 human evidence

Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction.

PubMed-indexed randomized controlled trial; journal article examining sublingual human chorionic gonadotropin as an adjuvant to ovulation induction. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Paula Almeida Galvão Ferreira; Luiz Augusto Giordano; Luiz Felipe Bittencourt
Source
JBRA assisted reproduction
DOI
10.1093/humrep/deh677
PubMed
38224574
Open original source
1997Phase 1–2 human evidence

Primary gonadotropin releasing hormone and adjunctive human chorionic gonadotropin treatment in cryptorchidism: a clinical trial.

PubMed-indexed clinical trial; journal article examining primary gonadotropin releasing hormone and adjunctive human chorionic gonadotropin treatment in cryptorchidism: a clinical trial. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
I Nane; O Ziylan; T Esen; T Kocak; H Ander; S Tellaloglu
Source
Urology
DOI
10.1016/S0090-4295(96)00359-7
PubMed
9000196
Open original source
1994Phase 1–2 human evidence

Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome.

PubMed-indexed clinical trial; journal article examining elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
K D Wenstrom; J Owen; L R Boots; M B DuBard
Source
American journal of obstetrics and gynecology
DOI
10.1016/0002-9378(94)90030-2
PubMed
7524322
Open original source
2004Observational human evidence

Human chorionic gonadotropin in cancer.

PubMed-indexed journal article; review examining human chorionic gonadotropin in cancer. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ulf-Håkan Stenman; Henrik Alfthan; Kristina Hotakainen
Source
Clinical biochemistry
DOI
10.1016/j.clinbiochem.2004.05.008
PubMed
15234236
Open original source
2010Observational human evidence

Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?

PubMed-indexed journal article examining are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Quyen Nguyen; Martha Kapitz; Katheryne Downes; Celso Silva
Source
American journal of obstetrics and gynecology
DOI
10.1016/j.ajog.2010.03.022
PubMed
20510964
Open original source
2013Observational human evidence

Determination of human chorionic gonadotropin.

PubMed-indexed journal article; review examining determination of human chorionic gonadotropin. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ulf-Håkan Stenman; Henrik Alfthan
Source
Best practice & research. Clinical endocrinology & metabolism
DOI
10.1016/j.beem.2013.10.005
PubMed
24275190
Open original source
1982Observational human evidence

Clinical utility of human chorionic gonadotropin and alpha-subunit measurements.

PubMed-indexed journal article; review examining clinical utility of human chorionic gonadotropin and alpha-subunit measurements. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
R O Hussa
Source
Obstetrics and gynecology
PubMed
6283446
Open original source
2008Observational human evidence

Ectopic pregnancy: diagnosis and management.

PubMed-indexed journal article examining ectopic pregnancy: diagnosis and management. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Jennifer L Kulp; Kurt T Barnhart
Source
Women's health (London, England)
DOI
10.2217/17455057.4.1.79
PubMed
19072453
Open original source
2009Observational human evidence

Treatment with human chorionic gonadotropin induces left ventricular mass in cryptorchid boys.

PubMed-indexed journal article examining treatment with human chorionic gonadotropin induces left ventricular mass in cryptorchid boys. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ozgur Pirgon; Mehmet Emre Atabek; Bulent Oran; Selami Suleymanoglu; Cihan Meral
Source
Journal of pediatric endocrinology & metabolism : JPEM
DOI
10.1515/jpem.2009.22.5.449
PubMed
19618664
Open original source
2012Observational human evidence

Medical management of ectopic pregnancy.

PubMed-indexed journal article; review examining medical management of ectopic pregnancy. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Gary H Lipscomb
Source
Clinical obstetrics and gynecology
DOI
10.1097/GRF.0b013e3182510a48
PubMed
22510624
Open original source
2024Observational human evidence

A Current Perspective on Delayed Puberty and Its Management.

PubMed-indexed journal article; review examining a current perspective on delayed puberty and its management. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Ayhan Abacı; Özge Besci
Source
Journal of clinical research in pediatric endocrinology
DOI
10.1136/archdischild-2016-311372
PubMed
38683021
Open original source
2025Observational human evidence

Optimal restoration of spermatogenesis after testosterone therapy using human chorionic gonadotropin and follicle-stimulating hormone.

PubMed-indexed journal article examining optimal restoration of spermatogenesis after testosterone therapy using human chorionic gonadotropin and follicle-stimulating hormone. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Blair T Stocks; Amelia G Oppenheimer; Kevin J Campbell; John P Lindsey; Taylor P Kohn; Juliet M Alexander; Jason B Huang; Larry I Lipshultz
Source
Fertility and sterility
DOI
10.1016/j.fertnstert.2024.10.019
PubMed
39442683
Open original source
2014Observational human evidence

Human chorionic gonadotropin and indolamine 2,3-dioxygenase in patients with GVHD.

PubMed-indexed journal article examining human chorionic gonadotropin and indolamine 2,3-dioxygenase in patients with gvhd. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
A H Elmaagacli; M Ditschkowski; N K Steckel; T Gromke; H Ottinger; U Hillen; H A Baba; R Trenschel; D W Beelen; M Koldehoff
Source
Bone marrow transplantation
DOI
10.1038/bmt.2014.59
PubMed
24686986
Open original source
2017Observational human evidence

Human Chorionic Gonadotropin: The Pregnancy Hormone and More.

PubMed-indexed journal article; review examining human chorionic gonadotropin: the pregnancy hormone and more. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Charalampos Theofanakis; Petros Drakakis; Alexandros Besharat; Dimitrios Loutradis
Source
International journal of molecular sciences
DOI
10.1177/1933719115597765
PubMed
28505106
Open original source
2022Observational human evidence

Human Chorionic Gonadotropin-A Review of the Literature.

PubMed-indexed journal article; review examining human chorionic gonadotropin-a review of the literature. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Darby Herkert; Vivienne Meljen; Lisa Muasher; Thomas M Price; Jeffrey A Kuller; Sarah Dotters-Katz
Source
Obstetrical & gynecological survey
DOI
10.1097/OGX.0000000000001053
PubMed
36136076
Open original source
2017Observational human evidence

Effects of human chorionic gonadotropin on testicular interstitial tissues in men with non-obstructive azoospermia.

PubMed-indexed journal article examining effects of human chorionic gonadotropin on testicular interstitial tissues in men with non-obstructive azoospermia. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
S Oka; K Shiraishi; H Matsuyama
Source
Andrology
DOI
10.1111/andr.12292
PubMed
27860441
Open original source
2017Observational human evidence

Human Chorionic Gonadotropin and Breast Cancer.

PubMed-indexed journal article; review examining human chorionic gonadotropin and breast cancer. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
Susanne Schüler-Toprak; Oliver Treeck; Olaf Ortmann
Source
International journal of molecular sciences
DOI
10.1159/000188665
PubMed
28754015
Open original source
1993Observational human evidence

Ectopic pregnancy.

PubMed-indexed journal article; review examining ectopic pregnancy. Machine-staged source candidate; findings and limitations require accountable review before publication.

Authors
B D Cowan
Source
Current opinion in obstetrics & gynecology
PubMed
8329648
Open original source

Scientific context

Chemistry and represented biological context

Existing reviewed chemistry is preserved as scientific context. Chemistry and mechanism information do not establish clinical efficacy or safety.

Open chemistry and biological context ↓
Chemical identity

Molecular and structural record

Structured record
Molecular weight (Da)
36700

Chemical identity describes the recorded molecular information. It does not establish biological activity, clinical efficacy, safety, or therapeutic suitability.

Explore further

Continue through the research system

Move from this peptide record into the project's broader evidence, research, comparison, and methodology systems.

Research discovery

Compare peptides

Examine represented peptide records side by side.

Evidence system

Explore how scientific evidence is represented and reviewed.

Research hub

Enter the broader research and intelligence environment.

Methodology

Review project methods, boundaries, and interpretation rules.

Research

How the scientific record is developing

Chronology, unresolved research questions, opportunities, and researcher activity remain descriptive rather than evaluative.

Research chronology

  1. 1982 · study · Temporal status not established

    Clinical utility of human chorionic gonadotropin and alpha-subunit measurements.

    Obstetrics and gynecology

  2. 1993 · study · Temporal status not established

    Ectopic pregnancy.

    Current opinion in obstetrics & gynecology

  3. 1994 · study · Temporal status not established

    Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome.

    American journal of obstetrics and gynecology

  4. 1995 · study · Temporal status not established

    Prediction of early pregnancy outcomes.

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

  5. 1997 · study · Temporal status not established

    Primary gonadotropin releasing hormone and adjunctive human chorionic gonadotropin treatment in cryptorchidism: a clinical trial.

    Urology

  6. 1999 · study · Temporal status not established

    Preoperative treatment with human chorionic gonadotropin in infancy decreases the severity of proximal hypospadias and chordee.

    The Journal of urology

  7. 2003 · study · Temporal status not established

    Prospective evaluation of human chorionic gonadotropin in the differentiation of undescended testes from retractile testes.

    The Journal of urology

  8. 2004 · study · Temporal status not established

    Human chorionic gonadotropin in cancer.

    Clinical biochemistry

  9. 2008 · study · Temporal status not established

    Ectopic pregnancy: diagnosis and management.

    Women's health (London, England)

  10. 2009 · study · Temporal status not established

    Treatment with human chorionic gonadotropin induces left ventricular mass in cryptorchid boys.

    Journal of pediatric endocrinology & metabolism : JPEM

  11. 2010 · study · Temporal status not established

    Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?

    American journal of obstetrics and gynecology

  12. 2012 · study · Temporal status not established

    Medical management of ectopic pregnancy.

    Clinical obstetrics and gynecology

  13. 2013 · study · Temporal status not established

    Medical abortion follow-up with serum human chorionic gonadotropin compared with ultrasonography: a randomized controlled trial.

    Obstetrics and gynecology

  14. 2013 · study · Temporal status not established

    Determination of human chorionic gonadotropin.

    Best practice & research. Clinical endocrinology & metabolism

  15. 2014 · study · Temporal status not established

    Human chorionic gonadotropin and indolamine 2,3-dioxygenase in patients with GVHD.

    Bone marrow transplantation

  16. 2017 · study · Temporal status not established

    A study of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer after two or more implantation failures.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

  17. 2017 · study · Temporal status not established

    Human Chorionic Gonadotropin: The Pregnancy Hormone and More.

    International journal of molecular sciences

  18. 2017 · study · Temporal status not established

    Effects of human chorionic gonadotropin on testicular interstitial tissues in men with non-obstructive azoospermia.

    Andrology

  19. 2017 · study · Temporal status not established

    Human Chorionic Gonadotropin and Breast Cancer.

    International journal of molecular sciences

  20. 2018 · study · Temporal status not established

    Should intrauterine human chorionic gonadotropin infusions ever be used prior to embryo transfer?

    Journal of assisted reproduction and genetics

  21. 2020 · study · Temporal status not established

    Human chorionic gonadotropin promotes recruitment of regulatory T cells in endometrium by inducing chemokine CCL2.

    Journal of reproductive immunology

  22. 2022 · study · Temporal status not established

    Human Chorionic Gonadotropin-A Review of the Literature.

    Obstetrical & gynecological survey

  23. 2024 · study · Temporal status not established

    Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction.

    JBRA assisted reproduction

  24. 2024 · study · Temporal status not established

    A Current Perspective on Delayed Puberty and Its Management.

    Journal of clinical research in pediatric endocrinology

  25. 2025 · study · Temporal status not established

    Optimal restoration of spermatogenesis after testosterone therapy using human chorionic gonadotropin and follicle-stimulating hormone.

    Fertility and sterility

  26. 2026 · regulatory · Temporal status not established

    Regulatory review: approved

    European Union

  27. 2026 · regulatory · Temporal status not established

    Regulatory review: approved

    United States

The represented chronology reflects records currently included in the governed dataset and does not claim to represent the entire scientific literature.

What still needs investigation

Claim traceability

No institutional claim record is currently represented for this peptide.

Evidence is missing or not represented as studied; this is not a conclusion that the intervention does not work.

Researchers represented in the evidence record12 bibliographic identities · open to inspect

These are bibliographic author identities derived from represented records. Name strings are not proof of unique real-world researcher identity, and publishing organizations are not treated as institutional affiliations.

Henrik Alfthan

2 represented evidence records

Years represented: 2004, 2013

Publishing organizations appearing in records: Best practice & research. Clinical endocrinology & metabolism, Clinical biochemistry

Ulf-Håkan Stenman

2 represented evidence records

Years represented: 2004, 2013

Publishing organizations appearing in records: Best practice & research. Clinical endocrinology & metabolism, Clinical biochemistry

A H Elmaagacli

1 represented evidence record

Years represented: 2014

Publishing organizations appearing in records: Bone marrow transplantation

Alexandros Besharat

1 represented evidence record

Years represented: 2017

Publishing organizations appearing in records: International journal of molecular sciences

Alisa B Goldberg

1 represented evidence record

Years represented: 2013

Publishing organizations appearing in records: Obstetrics and gynecology

Amelia G Oppenheimer

1 represented evidence record

Years represented: 2025

Publishing organizations appearing in records: Fertility and sterility

Ayhan Abacı

1 represented evidence record

Years represented: 2024

Publishing organizations appearing in records: Journal of clinical research in pediatric endocrinology

B D Cowan

1 represented evidence record

Years represented: 1993

Publishing organizations appearing in records: Current opinion in obstetrics & gynecology

Bartley G Cilento

1 represented evidence record

Years represented: 2003

Publishing organizations appearing in records: The Journal of urology

Beverley J Vollenhoven

1 represented evidence record

Years represented: 2018

Publishing organizations appearing in records: Journal of assisted reproduction and genetics

Blair T Stocks

1 represented evidence record

Years represented: 2025

Publishing organizations appearing in records: Fertility and sterility

Bo Zheng

1 represented evidence record

Years represented: 2020

Publishing organizations appearing in records: Journal of reproductive immunology

Connections

Follow the scientific relationships

Connections appear only when they are represented by the project’s underlying records.

Open 12 represented connections ↓

institution

The Journal of urology

represented evidence source

institution

Obstetrics and gynecology

represented evidence source

institution

American journal of obstetrics and gynecology

represented evidence source

institution

International journal of molecular sciences

represented evidence source

institution

Journal of assisted reproduction and genetics

represented evidence source

institution

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

represented evidence source

institution

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

represented evidence source

institution

Journal of reproductive immunology

represented evidence source

institution

JBRA assisted reproduction

represented evidence source

institution

Urology

represented evidence source

institution

Clinical biochemistry

represented evidence source

institution

Best practice & research. Clinical endocrinology & metabolism

represented evidence source

Traceability

Follow the record back to its source

The experience makes incomplete links visible instead of presenting a false impression of perfect provenance.

Source publication state

A governed source may be verified and approved for publication while its claim-to-evidence link is still incomplete.

Reviewer provenance state

“Human scientist reviewed: no” means that specific source-path attribution is not recorded. It does not silently negate the separate publication-review state.

Domain conclusion → Evidence

Connected

Evidence → Source

Connected

Source → Original record

Connected

Traceability documents how the project connects statements to records. It does not establish that a source is scientifically valid or that a claim is clinically true.

Reconciled for 6 domain conclusions and 0 featured studies.

Detailed study-to-domain mappings and original-source paths appear in the Human chorionic gonadotropin (hCG) evidence-governance section.

Inspect the ranked source records

Observational archive

What contributors reported

Observational archive data is intentionally separated from published scientific evidence.

Observational boundary

Insufficient eligible observations are available for display under the current filters.

Insufficient eligible observations are currently represented to display aggregated findings for this peptide.

Regulatory context

Published jurisdictional records

Regulatory status is jurisdiction-specific and time-dependent. It is presented as context, not as a recommendation for use or a substitute for scientific evidence evaluation.

European Union

Regulator: Not represented

approved

As of: 9/9/2026 · Temporal status not established

Regulatory context incomplete: regulator.

EMA medicines portal

Research + media

Media connected to this scientific record

Only media explicitly linked through the project’s relationship system appears here.

No scientifically connected media is currently represented for this peptide.

Sources + provenance

Read the scientific record with its boundaries intact

The public record organizes reviewed evidence; it does not establish scientific truth by itself.
Association, mechanism, observation and regulatory status must not be represented as proof of clinical efficacy or safety.
Observational reports describe contributor experiences and cannot establish causation, effectiveness, safety or clinical benefit.
Contradictory and qualifying evidence must remain visible rather than being silently discarded.
Absence of represented evidence is not evidence that research does not exist.
Research gaps identify unresolved questions; they are not negative conclusions.
Regulatory status is distinct from scientific evidence quality.
Media relationships provide context and explanation; they do not increase the strength of scientific evidence.
A section with no represented records is an incomplete project record, not a scientific conclusion.
Researcher and institutional relationships are shown only when supported by represented records and must not be interpreted as rankings or endorsements.

Generated: 11/8/2026, 5:24:53 PM

global evidence atlas

Human chorionic gonadotropin (hCG) research, ranked and separated by purpose

This is a deduplicated literature screening registry—not a claim that every mention directly proves efficacy or safety. Machine proposals remain visibly separate from governed human appraisal.

722Discoverable source universe
500Ranked screening records
6Research domains
0Accountably approved conclusions

500 matching records · ranked 2026-09-18

Page 1 of 20

Count reconciliation: 722 discoverable source records match the peptide identity query; 500 are retained in this bounded, ranked screening view; 0 belong to the separate governed layer labeled “Accountably approved conclusions.” Domain totals overlap because one publication may inform several questions.

governance and regulatory context

Human chorionic gonadotropin (hCG): what this atlas does and does not establish

Last checked
2026-09-18
Accountable publication approval
Not yet approved by a named accountable reviewer. Machine screening only.

No new outcome conclusion is inferred from discovery metadata. Named accountable approval is required for governed scientific conclusions.

Regulatory status by jurisdiction

Absence of a record in this pass is not proof that no authorization exists. Status must remain jurisdiction-, product-, formulation-, and date-specific.

2 FDA structured product label record(s) were identified for this compound name in openFDA. Label presence reflects an approved product exists under that name; it is not a claim about the specific formulation, dose, or use being discussed anywhere else on this page.

No machine-proposed evidence-strength grades exist yet for this compound; all screening records are unassigned pending further review.

Human chorionic gonadotropin (hCG) evidence · ranking key

How evidence is ranked

A tier describes the evidentiary role and design strength of a source. It is not a popularity score, proof that every conclusion is correct, or a substitute for claim-level review.

A

Practice-defining evidence

Large, well-conducted randomized trials; prespecified major outcomes; rigorous systematic reviews or meta-analyses; and major regulatory assessments.

B

Strong supporting evidence

Smaller randomized trials, strong prospective cohorts, prespecified secondary analyses, and high-quality comparative-effectiveness studies.

C

Contextual evidence

Retrospective cohorts, claims-database studies, pharmacovigilance analyses, mechanistic human research, and well-documented case series.

D

Signal-generating evidence

Case reports, conference abstracts, preclinical research, hypothesis-generating analyses, and expert commentary.

Tier and confidence answer different questions

Tier classifies source design and evidentiary role. Confidence reflects risk of bias, sample size, comparator quality, outcome relevance, follow-up, missing data, directness, replication, reporting quality, and whether conclusions stay within the measured results.

Funding and conflicts are disclosed and considered, but sponsorship never automatically changes a tier. Corrections, retractions, and expressions of concern override the original rating.

peptide explorer

Structural visualization and provenance

Evidence-class labeling remains visible even when interactive rendering is unavailable. Representative geometry is not an experimentally determined or predicted biological conformation.

Fully specified molecular identity

Molecular formula
Variable / not singular
Molecular weight
36700 g/mol
Exact identity / sequence notation
Disulfide-rich α/β glycoprotein heterodimer: common glycoprotein-hormone α subunit (P01215) + hCG β subunit (P0DN86), with heterogeneous N- and O-linked glycans
Identity-defining modifications
  • Two noncovalently associated protein subunits
  • Multiple intrachain disulfides
  • Two N-glycosylation sites on α; two N- and four O-glycosylation sites on β
  • Native glycoforms are heterogeneous
UniProt subunits
P01215 + P0DN86
InChIKey
Not applicable / not verified

No single invariant molecular formula, InChIKey, or residue-only viewer sequence honestly represents native hCG. Approximate mass varies with glycosylation; the linked PDB is an experimental heterodimer structure, not a complete glycoform inventory.

Sources: UniProt — glycoprotein hormones alpha chain (P01215) · UniProt — chorionic gonadotropin beta chain (P0DN86) · RCSB PDB — hCG heterodimer (1HCN) · reviewed 2026-09-17

Verified structure unavailable
Structure source
Not represented
Identifier
Not represented
Method
Not represented
Confidence / limitations
Not represented
Provenance
Not represented
Retrieved / last reviewed
Not represented

No reliable structure is available for this record. This is a preserved, honest state, not an error — it is never auto-filled with an unverified structure.

Suggested citation

  • APA

    World Peptide Foundation. (n.d.). Human chorionic gonadotropin (hCG) — Peptide Scientific Intelligence. World Peptide Foundation. (Updated September 20, 2026.) https://www.worldpeptidefoundation.org/directory/human-chorionic-gonadotropin

  • AMA / Vancouver

    World Peptide Foundation. Human chorionic gonadotropin (hCG) — Peptide Scientific Intelligence. World Peptide Foundation website. Updated September 20, 2026. https://www.worldpeptidefoundation.org/directory/human-chorionic-gonadotropin