# PT-141: the brain’s role in desire

World Peptide Foundation — Peptides in 2
Collection: Reproductive & Sexual Health

## Primary references

1. Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003;994:96–102. https://pubmed.ncbi.nlm.nih.gov/12851303/
2. Palatin Technologies. PT-141 Phase 2B company announcement, November 1, 2002. This is historical company reporting. https://www.sec.gov/Archives/edgar/data/911216/000108802003000076/exhibit99.htm
3. Kingsberg SA et al. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials. Obstet Gynecol. 2019;134:899–908. https://pubmed.ncbi.nlm.nih.gov/31599840/ — https://pmc.ncbi.nlm.nih.gov/articles/PMC6819021/
4. Vyleesi prescribing information. Indication, receptor pharmacology, amino-acid connectivity, safety and clinical endpoints. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f1d0c1b5-2f39-4bad-a6a4-0066e3ad5dcf&type=display
5. FDA approval date verification: June 21, 2019. Federal Register, August 20, 2020. https://www.govinfo.gov/content/pkg/FR-2020-08-20/pdf/FR-2020-08-20.pdf

## Production

Narrator: established Tom voice, steady narration. One paid narration generation, 1,779 characters, 36 Runway credits. No paid imagery, video generation or music generation. Local editing tightens pauses and adjusts pace without regenerating speech. Original WPF title artwork retrieved from the site; all content slides and diagrams created locally for this film. Geographic outline from PublicaMundi MappingAPI US states data; locator indicates Cranbury, not trial geography. Protein/receptor graphics show concepts and residue connectivity, not experimentally resolved atomic coordinates.

No original authors, institutions, regulators or study participants are represented as endorsing this film. The 2003 coauthors are credited for the publication, not asserted to be the sole inventors. No exact invention date is inferred from publication dates. Seven years refers to time since US approval, not universal clinical use.

## QA scope

Video/stream integrity, dimensions, runtime and scene samples are checked locally. Captions are aligned against the approved text using local acoustic alignment. Narration pronunciation still requires owner listening review; no claim of human listening or independent scientific review is made.