# KPV — film sources and visual provenance

1. Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. FASEB J. 1989;3(11):2282–2284. https://pubmed.ncbi.nlm.nih.gov/2550304/ DOI: 10.1096/fasebj.3.11.2550304
   Supports: Dallas affiliation, named researchers, documented 1989 work, reduced induced swelling in mice. This is an early published milestone, not a claim that the molecule was first synthesized in 1989.
2. Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166–178. https://pubmed.ncbi.nlm.nih.gov/18061177/ Full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC2431115/ DOI: 10.1053/j.gastro.2007.10.026
   Supports: alpha-MSH terminal sequence, Emory affiliation, intestinal/immune cell-line transport, NF-kappaB and MAPK findings, mouse DSS/TNBS colitis. Human-derived cell lines are not human clinical trials.
3. Kannengiesser K, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(3):324–331. https://pubmed.ncbi.nlm.nih.gov/18092346/ DOI: 10.1002/ibd.20334
   Supports: University of Münster team, earlier recovery, regained body weight and reduced inflammatory histological changes in mouse colitis models. No human treatment claim.
4. FDA. KPV-related bulk drug substances briefing document, Pharmacy Compounding Advisory Committee, July 23–24, 2026. https://www.fda.gov/media/193346/download
   Supports: neither KPV free base nor KPV acetate is a component of an FDA-approved drug; human clinical and safety evidence gaps. This briefing is not a final compounding decision. This film does not assert a new HHS policy, authorization to compound, or a restriction for a specific route.

## Visual provenance
Ten new illustrations generated for this film using the built-in image-generation tool. No finished illustration from a previous film was reused. Established WPF title artwork is preserved for intro/outro. Three native animations created for this film: schematic peptide transport, three-amino-acid research question, and molecular closing sequence. Exact prompts are in Artwork-Prompts.json.

Images are scientific illustrations or fictional documentary-style settings, not photographs of the named researchers, actual studies or treatment outcomes. The historical laboratory image does not depict Hiltz or Lipton. The peptide rendering is not an exact atomic model. The transporter animation is a schematic of uptake, not a solved KPV-PepT1 structure. Laboratory and mouse imagery do not constitute evidence. On-page synthetic imagery/narration disclosure should follow the established film template.

## Review
Script source verification completed October 31, 2026. Owner listening/pronunciation review remains pending. No dosing instructions or purchasing recommendations.